Patent US1902465A successfully refreshed from Google Patents.
EP0502814A2
Expired / Lapsed
EP
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Compositions for increasing the image contrast in imaging of the digestive tract of patients
Assignee: Bracco International BV
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Filing: 1992-02-05
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Granted: —
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Expires: 2012-02-05
Abstract
Abstract Suspensions of magnetic particles in aqueous bioadhesive carriers effectively improve MRI of the digestive tract. Affinity of the compositions for the gastric mucosa can be adapted to the needs by appropriately selecting the carrier in function to inherent bioadhesive capacity : this technique leads to improved visualization of selected portions of the lumen.
Inventors
- 👤 Hervé Tournier
- 👤 Roland Hyacinthe
- 👤 Friedrich Cavagna
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:51
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1833; A61K49/1845; A61K49/1851; A61K49/1854; A61K49/1863; A61K49/189; A61K49/1893; A61K49/22; A61K49/222; A61K49/223; A61K49/226; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
121 words
Administrable diagnostic compositions for enhancing the image contrast in the ultrasonic and, respectively, NMR imaging of the digestive tract of humans and animals, said compositions respectively comprising, as contrast enhancing agent in admixture with or chemically bonded to at least one physiologically acceptable carrier phase, one or more members of the group consisting of signal enhancing ultrasonically and magnetically responsive particles, characterized in that said carrier phase is substantially water insoluble, although swellable by hydration and gel forming, and, when hydrated, has differential affinity for the gastro-intestinal mucosa, i.e. it adheres preferably to some areas thereof, thus forming luminal linings or coatings having specific imaging contrast response which enable improved visualization of specific portions, and relative motions, of the oeso-gastro-duodenal tract
Claim 2
Dependent Claim
44 words
The compositions of claim 1, in which the carrier is a hydratable gel-forming bioadhesive carrying groups selected from one or more of carboxy, sulfate, sulfonate, phosphate and phosphonate, these groups being either free or in the form of salts with alkali of alkaline-earth metals.
Claim 3
Dependent Claim
16 words
The compositions of claim 2, in which the carrier is selected from polysulfated and polyphosphated carbohydrates.
Claim 4
Dependent Claim
26 words
The compositions of claim 1, in which the carrier is a luminal coating compound selected from hydratable clays, e.g. Attapulgite and Montmorillonite, and hydroxylated coatable polysaccharides.
Claim 5
Dependent Claim
48 words
The compositions of claim 1, in which the carrier is a bioadhesive, hydratable, gel-forming polymer or copolymer of acrylic acid and, optionally, other monomers, this polymer or copolymer bearing carboxylate of sulfonate groups, said groups being free or in the form of salts with alkali or alkaline-earth metals.
Claim 6
Dependent Claim
37 words
The compositions of claim 1, in which the magnetically responsive particles are uncoated particles of magnetite or superparamagnetic metal oxides and the ultrasonically responsive particles are air- or gas-filled microspheres surrounded by an envelope of polymeric material.
Claim 7
Dependent Claim
38 words
The compositions of claim 1, further comprising dispersions of contrast enhancing particles in an aqueous solution of one or more water-soluble polymer carrier, the amount of said particles to said water-soluble polymer carrier, measured dry, not exceeding 5%.
Claim 8
Dependent Claim
41 words
The compositions of claim 7, in which the proportion of said dispersions is up to 100% of the total of the compositions and the water-soluble polymer carrier is selected from dextran, polyvinyl-pyrrolidone (PVP), Carboxymethylcellulose (CMC), hydroxypropyl-cellulose and other water-soluble non-metabolizable polymers.
Claim 9
Dependent Claim
22 words
The compositions of claim 1, in which the particles are bonded to the bioadhesive carrier substrate by means of a chemical coupler.
Claim 10
Dependent Claim
27 words
The compositions of claim 9, in which said coupler has reactive functions of which one will bind to the particles and another will bind to the carrier.
Claim 11
Dependent Claim
50 words
The compositions of claim 10, in which the carrier is a polymer or copolymer of acrylic acid and, optionally other unsaturated monomers, and in which said another function of the coupler comprises an ethylenically unsaturated double bond, said another function being copolymerized with said polymer or copolymer of acrylic acid.
Claim 12
Dependent Claim
29 words
The compositions of claim 10, in which said one function of the coupler is a trialkoxy-silane function which binds to the magnetic particles through formation of a silicon-containing bond.
Claim 13
Independent Claim
91 words
A method for manufacturing ingestible compositions to be used as contrast enhancing agents in the NMR Imaging of the digestive tract of humans and animals, said compositions comprising image contrast enhancing particles and at least a carrier phase consisting of a water-soluble or water-insoluble mineral or organic substrate, characterized in adjusting the pH of a dispersion of the particles in an aqueous medium to a value of at least 13, admixing the carrier phase with said dispersion and separating the product of addition of the magnetic particles and the carrier phase.
Claim 14
Dependent Claim
41 words
The method of claim 13, in which the carrier phase is an organic polymer or oligomer, optionally carrying carboxylic or sulfate groups, and separation is achieved by dilution with a water-soluble solvent in which said product of addition is not soluble.
Claim 15
Independent Claim
86 words
A method for manufacturing ingestible compositions to be used as contrast enhancing agents in the ultrasonic or NMR Imaging of the digestive tract of humans and animals, said compositions comprising image contrast enhancing particles bound to a carrier phase consisting of a water-insoluble mineral or organic substrate, characterized in selecting a coupler with at least two reactive functions, grafting the coupler to the particles through one of said reactive functions and binding said grafted particles to said carrier phase through the other of said reactive functions.
Claim 16
Dependent Claim
51 words
The method of claim 15, in which the organic substrate is a polymer or copolymer of acrylic acid and, optionally, other copolymerizable monomers, characterized in copolymerizing said acrylic acid in the presence of said grafted particles, said other reactive function of the coupler having a double bond copolymerizable with acrylic acid.
Claim 17
Independent Claim
103 words
A method for the ultrasonic or NMR imaging the digestive tract of human and animal patients in which an imaging composition comprising an image contrast enhancing agent incorporated to a biocompatible carrier phase is orally or enterally administered to said patient and the successive sections of the digestive tract are then imaged as said carrier phase transits therethrough, characterized in that the nature of carrier phase and the concentration of contrast agent therein are selected to effect control on the rate of said transit and on the retention time of said contrast agent in each of said sections depending on the imaging needs.
Claim 18
Dependent Claim
28 words
The method of claim 17, in which the nature of carrier phase is selected by its degree of bioadhesive capacity to the mucosa membrane of the digestive tract.
Claim 19
Dependent Claim
17 words
The method of claim 18, in which the carrier phase is a water-insoluble, gel-forming luminal lining compound.
Claim 20
Dependent Claim
25 words
The method of claim 19, in which the carrier phase is selected at least in part from Carbopol®, Sucralfate®, Attapulgite, Montmorillonite, magnesium alginate and pectin.
Claim 21
Dependent Claim
21 words
The method of claim 18, in which the carrier phase contains also a water-soluble polymer for accelerating said rate of transit.
References Cited (Backward Citations)
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