3-Cycloalkylpropanamides, their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them

Abstract

Abstract Translated from French L'invention concerne les produits (I): dans laquelle : - R 1 = cycloalkyle, R 2 = H ou alkyle, R 3 , R 4 , R 5 , R 6 etR 7 = halogène, alkyle, alkoxy, alkylthio, -(CH 2 ) m CF 3 , -O-(CH 2 ) m CF 3 , -S-(CH 2 ) m- CF 3 , -CF 2 -Hal, -OCF 2 -Hal, or -O(CF 2 ) n CF-Hal 3 -CF 3 , nitro, azido, nitrile, -CO-R' avec m = 0 à 3, n= 1 to 3, Hal, Hal 1 , Hal 2 et Hal 3 = halogène, R' = OH, alkyle, alkoxy, ou R 3 et R 4 forment ensemble -O-CH 2 -O-, et leurs formes tautomères, leurs sels avec les bases, leur procédé et les intermédiaires de préparation ainsi que leur application comme médicaments notamment anti-inflammatoires et les compositions pharmaceutiques les renfermant. The invention relates to the products (I): in which : - R 1 = cycloalkyl, R 2 = H or alkyl, R 3 , R 4 , R 5 , R 6 and R 7 = halogen, alkyl, alkoxy, alkylthio, - (CH 2 ) m CF 3 , -O- (CH 2 ) m CF 3 , -S- (CH 2 ) m- CF 3 , -CF 2 -Hal, -OCF 2 -Hal, or -O (CF 2 ) n CF-Hal 3 -CF 3 , nitro, azido, nitrile, -CO-R 'with m = 0 to 3, n = 1 to 3, Hal, Hal 1 , Hal 2 and Hal 3 = halogen, R' = OH, alkyl, alkoxy, or R 3 and R 4 together form -O-CH 2 -O-, and their tautomeric forms, their salts with bases, their process and the preparation intermediates as well as their application as drugs, in particular anti-inflammatory drugs and the pharmaceutical compositions containing them.

Inventors

• 👤 Philip Thomas Hambleton
• 👤 Charles John Robert Hedgecock
• 👤 David Paul Kay
• 👤 Elizabeth Anne Kuo
• 👤 Wilfred Roger Tully

Bibliographic Details