EP0482649A2
Expired / Lapsed
EP
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CM-chitin derivatives and use thereof
Assignee: Fujifilm Holdings Corp
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Filing: 1991-10-24
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Granted: —
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Expires: 2011-10-24
Abstract
Abstract A CM-chitin derivative has, as an essential unit, a adhesive peptide represented by the following general formula (I), on the side chain, through any one of amido bond, ester bond, ether bond and urethane bond or a salt thereof: wherein the bracket [ ] means that the corresponding group or residue may be present or absent and if they are present, X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue; Z represents -O- or -NH-; one of R 1 and R 2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group having 1 to 9 carbon atoms or aryl group having 6 to 9 carbon atoms and the other represents a hydrogen atom, a linear or branched alkylene group having 1 to 9 carbon atoms or an arylene group having 6 to 9 carbon atoms wherein the alkylene and arylene groups may have substituents; and n is an integer ranging from 1 to 5. The derivative or salt thereof is useful as an effective component of compositions for inhibiting adhesion of animal cells or for inhibiting coagulation adhesion of blood platelets.
Inventors
- 👤 Masayoshi c/o Fuji Photo Film Co. Ltd. Kojima
- 👤 Hiroyuki c/o Fuji Photo Film Co. Ltd. Komazawa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 06:38
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; C07; C07K; C07K14/00; C07K14/435; C07K14/78; C07K9/00; C07K9/001; C07K9/005; A61K38/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
184 words
A CM-chitin derivative having, as an essential unit, a cohesive peptide represented by the following general formula (I), on the side chain, through any one of amido bond, ester bond, ether bond and urethane bond or a salt thereof: wherein the bracket [ ] means that the corresponding group or residue in the bracket may be present or absent and if they are present, X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue consisting of two or more of the amino acids; Z represents -O- or -NH-; one of R 1 and R 2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group having 1 to 9 carbon atoms or aryl group having 6 to 9 carbon atoms and the other represents a hydrogen atom, a linear or branched alkylene group having 1 to 9 carbon atoms or an arylene group having 6 to 9 carbon atoms wherein the alkylene and arylene groups may have substituents; and n is an integer ranging from 1 to 5.
Claim 2
Dependent Claim
184 words
A CM-chitin derivative having, as an essential unit, a cohesive peptide represented by the following general formula (I), on the side chain, through any one of amido bond, ester bond, ether bond and urethane bond or a salt thereof: wherein the bracket [ ] means that the corresponding group or residue in the bracket may be present or absent and if they are present, X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue consisting of two or more of the amino acids; Z represents -O- or -NH-; one of R 1 and R 2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group having 1 to 9 carbon atoms or aryl group having 6 to 9 carbon atoms and the other represents a hydrogen atom, a linear or branched alkylene group having 1 to 9 carbon atoms or an arylene group having 6 to 9 carbon atoms wherein the alkylene and arylene groups may have substituents; and n is an integer ranging from 1 to 5.
Claim 3
Dependent Claim
20 words
The CM-chitin derivative or the salt of claim 1 wherein it has a molecular weight of not more than 200,000.
Claim 4
Dependent Claim
20 words
The CM-chitin derivative or the salt of claim 2 wherein it has a molecular weight ranging from 3,000 to 100,000.
Claim 5
Dependent Claim
47 words
The CM-chitin derivative or the salt of claim 1 wherein the substituent of R 1 and R 2 is at least one member selected from the group consisting of halogen atoms, carbonyl, carboxyl, amino, hydroxyl, sulfo, aryl, nitro and cyano groups, unsaturated double bond and triple bond.
Claim 6
Dependent Claim
16 words
The CM-chitin derivative or the salt of claim 1 wherein it is water-soluble at room temperature.
Claim 7
Dependent Claim
32 words
The CM-chitin derivative or the salt of claim 1 wherein the CM-chitin is sulfated or carboxylated with succinic anhydride, maleic anhydride, phthalic anhydride, itaconic anhydride, citraconic anhydride, pyromellitic anhydride or trimellitic anhydride.
Claim 8
Dependent Claim
19 words
The CM-chitin derivative or the salt of claim 1 wherein amino acids included in the adhesive peptide are L-isomers.
Claim 9
Dependent Claim
30 words
The CM-chitin derivative or the salt of claim 1 wherein the salt is selected from the group consisting of hydrochloride, sulfate, nitrate, phosphate, borate, acetate, trifluoroacetate, trifluoromethanesulfonate, lactate and tartrate.
Claim 10
Dependent Claim
32 words
A composition for inhibiting adhesion of animal cells comprising, as an effective component, at least one member selected from the group consisting of CM-chitin derivatives and salts thereof according to claim 1.
Claim 11
Dependent Claim
23 words
The composition of claim 9 wherein the dose of the CM-chitin derivative or salt thereof ranges from 0.2 u, g/kg to 400 mg/kg.
Claim 12
Dependent Claim
11 words
The composition of claim 9 wherein it further comprises a stabilizer.
Claim 13
Dependent Claim
11 words
The composition of claim 9 wherein it is encapsulated into liposomes.
Claim 14
Dependent Claim
32 words
A composition for inhibiting coagulation adhesion of platelets comprising, as an effective component, at least one member selected from the group consisting of CM-chitin derivatives and salts thereof according to claim 1.
Claim 15
Dependent Claim
22 words
The composition of claim 13 wherein the dose of the CM-chitin derivative or salt thereof ranges from 0.2µ g/kg to 400 mg/kg.
Claim 16
Dependent Claim
11 words
The composition of claim 13 wherein it further comprises a stabilizer.
Claim 17
Dependent Claim
11 words
The composition of claim 13 wherein it is encapsulated into liposomes.
References Cited (Backward Citations)
No citation records indexed.
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