EP0475077B1
Expired / Lapsed
EP
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Bone regeneration membrane
Assignee: AO Technology AG
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Filing: 1991-08-07
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Granted: 1996-06-12
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Expires: 2011-08-07
Abstract
Abstract A bone regeneration membrane containing resorbable or degradable, polymeric and/or polymeric-ceramic material with a glass transition temperature in the range of -30 DEG to + 200 DEG C. The novel membrane can be used for the spontaneous regeneration of bone and for the improved application of autologous or allogenic graft materials and therapeutic agents. <IMAGE>
Inventors
- 👤 Sylwester Gogolewski
- 👤 Stephan M. Perren
- 👤 Richard M. Meinig
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 21:00
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/80; A61B17/8085; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2846; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L31/04; A61L31/06; A61L31/12; A61L31/125; A61L31/127; A61L31/16; C; C08; C08L; C08L5/00; C08L67/00; C08L67/04; C08L73/00; C08L73/02; C08L79/00; C08L79/02; C08L89/00; A61B17/60; A61B17/64; A61B17/84; A61B17/842; A61B2017/00831; A61B2017/00867; A61F2/0077; A61F2/30; A61F2/30767; A61F2/3094; A61F2/30965; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30092; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2002/30291; A61F2002/30293; A61F2002/30316; A61F2002/30329; A61F2002/30462; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0014; A61F2220/00; A61F2220/0025; A61F2220/0075; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2230/0091; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
104 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material, characterized in that A) said polymeric material comprises polyhydroxyacids, polysaccharides, polyamines, polyaminoacids, polyorthoesters, polyanhydrides, collagen or composites thereof with tricalcium phosphate and/or hydroxyapatite; B) at least 90 weight percent of said polymeric and/or polymeric-ceramic material has a molecular weight in the range of 5'000 to 1'000'000; C) said polymeric and/or polymeric-ceramic material has a molecular weight distribution in the range of 1,2 to 100,0; D) the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of -30° to + 200°C; and E) said membrane is provided with micropores.
Claim 2
Dependent Claim
33 words
A membrane according to claim 1, characterized in that said glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of +10° to + 90°C, preferably between +30 to +70°C.
Claim 3
Dependent Claim
43 words
A membrane according to claim 1 or 2, characterized in that at least 90 percent of said micropores have a diameter below 500 µm, preferably in the range of 0,01 to 50,0 µm, most preferably in the range of 0,1 to 5 µm.
Claim 4
Dependent Claim
18 words
A membrane according to one of the claims 1 to 3, characterized in that said micropores are interconnected.
Claim 5
Dependent Claim
36 words
A membrane according to one of the claims 1 to 4, characterized in that at least 99 weight percent of said polymeric and/or polymeric-ceramic material has a molecular weight in the range of 5'000 to 1'000'000.
Claim 6
Dependent Claim
23 words
A membrane according to one of the claims 1 to 5, characterized in that it further comprises reinforcement including resorbable and/or degradable fibers.
Claim 7
Dependent Claim
37 words
A membrane according to one of the claims 1 to 6, characterized in that it has a thickness of between 0,05 to 5,0 mm, preferably between 0,2 to 3,0 mm, most preferably between 0,4 to 1,5 mm.
Claim 8
Dependent Claim
42 words
A membrane according to one of the claims 1 to 7, characterized in that at least 90 weight percent of said polymeric material has a molecular weight in the range of 25'000 to 150'000, preferably in the range of 30'000 to 70'000.
Claim 9
Dependent Claim
20 words
A membrane according to one of the claims 1 to 8, characterized in that said polymeric material is highly purified.
Claim 10
Dependent Claim
19 words
A membrane according to one of the claims 1 to 9, characterized in that it further contains antibiotic agents.
Claim 11
Dependent Claim
19 words
A membrane according to one of the claims 1 to 10, characterized in that it further contains antiosteomyelitis agents.
Claim 12
Dependent Claim
19 words
A membrane according to one of the claims 1 to 11, characterized in that it further contains antineoplastic agents.
Claim 13
Dependent Claim
26 words
A membrane according to one of the claims 1 to 12, characterized in that it further contains osteoconductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 14
Dependent Claim
26 words
A membrane according to one of the claims 1 to 13, characterized in that it further contains osteoinductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 15
Dependent Claim
23 words
A membrane according to one of the claims 1 to 14, characterized in that it has a curved surface, preferably a rectilinear surface.
Claim 16
Dependent Claim
20 words
A membrane according to claim 15, characterized in that said rectilinear surface is an adaptable surface, preferably a cylindrical surface.
Claim 17
Dependent Claim
19 words
A membrane according to one of the claims 1 to 16, characterized in that it has a shape memory.
Claim 18
Dependent Claim
26 words
A membrane according to one of the claims 1 to 16 characterized in that it is formable into a tubular form, preferably with a longitudinal slit.
Claim 19
Dependent Claim
31 words
A membrane according to claim 18, characterized in that it is adapted to form semi-occlusive fits at the two extremities of the tube formed by said membrane for fixation to bones.
Claim 20
Dependent Claim
30 words
A membrane according to claim 18, characterized in that it has ends shaped to form semi-occlusive fits over cortical bone ends and within medullary canals of long or tubular bones.
Claim 21
Dependent Claim
19 words
A membrane according to claim 18 , characterized in that it comprises a sheet prefashioned into a tubular form.
Claim 22
Dependent Claim
19 words
A membrane according to claim 18 , characterized in that it is rolled up to form a multilayer tube.
Claim 23
Dependent Claim
31 words
A membrane according to one of the claims 1 to 22, characterized in that said polymeric and/or polymeric-ceramic material has a molecular weight distribution in the range of 1,9 to 2,5.
References Cited (Backward Citations)
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