EP0473431A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
Assignee: Kenvue Brands LLC
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Filing: 1991-08-29
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Granted: —
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Expires: 2011-08-29
Abstract
Abstract Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. famotidine binder, e.g. polyvinylpyrrolidone, and carrier, e.g. lactose and the rotogranules are coated with cellulose acetate, cellulose acetate butyrate or a combination thereof and polyvinyl pyrrolidone and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules.
Inventors
- 👤 Edward J. Roche
- 👤 Susan M. Papile
- 👤 Eleanor M. Freeman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 20:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/0058; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/5036; A61K9/5042
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
46 words
A chewable tablet of a medicament comprising compressed coated rotogranules, said coated granules individually comprising medicament which has been rotogranulated with a binder and a carrier material and coated with a polymer blend of cellulose acetate, cellulose acetate butyrate or a combination of both with polyvinylpyrrolidone.
Claim 2
Dependent Claim
21 words
The chewable tablet of claim 1, wherein the medicament is famotidine, loperamide, cimetidine, ranitidine, a salt thereof or a combination thereof.
Claim 3
Dependent Claim
37 words
The chewable tablet of claim 1 or claim 2, wherein the coating mixture has a weight ratio in the range of from 95:5 to 60:40 of cellulose acetate, cellulose acetate butyrate or a combination thereof to polyvinylpyrrolidone.
Claim 4
Dependent Claim
31 words
The chewable tablet of any one of claims 1 to 3, wherein the polymer blend coating comprises from 5 to 20% by weight of the total weight of the coated granules.
Claim 5
Dependent Claim
39 words
The chewable tablet of any one of claims 1 to 4, wherein the rotogranules comprise from 2 to 85% medicament, 4 to 10% binder and 10 to 94% carrier by weight of the total weight of the uncoated granule.
Claim 6
Dependent Claim
25 words
The chewable tablet of any one of claims 1 to 5, wherein the medicament is famotidine, the binder is polyvinylpyrrolidone and the carrier is lactose.
Claim 7
Dependent Claim
20 words
The chewable tablet of any one of claims 1 to 6, wherein the coated granules are substantially spherical in shape.
Claim 8
Dependent Claim
18 words
A rotogranulation composition for use in preparing a chewable tablet of any one of claims 1 to 7.
Claim 9
Dependent Claim
40 words
A process for producing coated medicament rotogranulations comprising the steps of: preparing a rotogranulation composition of medicament, binder and a carrier; and coating the medicament rotogranulation composition with cellulose acetate, cellulose acetate butyrate or a combination of both and polyvinylpyrrolidone.
Claim 10
Dependent Claim
26 words
The process of claim 9, further including the step of forming a chewable tablet by compressing the coated medicament rotogranulation composition in the presence of excipients.
Claim 11
Dependent Claim
20 words
The process of claim 9 or claim 10, which produces a product of any one of claims 1 to 8.
References Cited (Backward Citations)
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