EP0470443A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Method for rendering a substrate surface antithrombogenic and/or anti-infective
Assignee: Becton Dickinson and Co
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Filing: 1991-07-25
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Granted: —
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Expires: 2011-07-25
Abstract
Abstract A shaped medical article of a polymeric substrate is extrusion coated with a composition which includes a bioactive agent dispersed in a matrix polymer. Preferred bioactive agents are temperature sensitive agents which undergo thermal decomposition at a temperature above the processing temperature of the matrix polymer. Preferred matrix polymers have a melting point of about 100°C or lower.
Inventors
- 👤 Fidelis C. Onwumere
- 👤 Donald D. Solomon
- 👤 Stanley C. Wells
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 17:18
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; A61L33/0047; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/42; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
89 words
A method for applying a temperature sensitive bioactive agent to the surface of a shaped polymeric substrate comprising: (a) combining a matrix polymer having a melting point of about 100°C or lower with a bioactive agent having a thermal decomposition point above said melting point; (b) melt compounding said polymer and agent within the temperature range between said melting point and said decomposition point to give a homogeneous composition; and (c) extrusion coating said composition onto the surface of a shaped polymeric substrate at a temperature within said range.
Claim 2
Dependent Claim
11 words
The method of Claim 1 wherein said substrate is a rod.
Claim 3
Dependent Claim
11 words
The method of Claim 1 wherein said substrate is a tubing.
Claim 4
Dependent Claim
28 words
The method of Claim 1 wherein said polymeric substrate is selected from the group of polymers consisting of polyacrylate, polystyrene, polyethylene, polypropylene, polytetrafluoroethylene, polyester, polyamide, polyvinyl and polyurethane.
Claim 5
Dependent Claim
32 words
The method of Claim 1 wherein said matrix polymer is selected from the group consisting of ethylene acrylic acid copolymer, polycaprolactone, polyethylene adipate, polybutylene adipate, polyethylene azeleate and polyethylene methacrylic acid ionomer.
Claim 6
Dependent Claim
22 words
The method of Claim 1 wherein said agent is selected from the group consisting of an anti-infective agent and an antithrombogenic agent.
Claim 7
Dependent Claim
32 words
The method of Claim 1 wherein said melt compounding step is performed by extrusion compounding particles of said matrix polymer and particles of said agent at a temperature of 100°C or less.
Claim 8
Independent Claim
71 words
A method for applying an agent to the surface of a polymeric article comprising: a) preparing a homogeneous composition comprising a melt of a matrix polymer and a material selected from the group consisting of a bioactive agent and a binder for a bioactive agent, b) extrusion coating said composition onto a surface of a polymeric article at a temperature at which said material does not undergo any substantial thermal decomposition.
Claim 9
Dependent Claim
36 words
The method of Claim 7 wherein said binder is a quaternary ammonium salt and said method further comprises reacting said salt with an aqueous solution containing a bioactive agent which forms a complex with said salt.
Claim 10
Independent Claim
100 words
A method for applying a temperature sensitive bioactive agent to the surface of a shaped polymeric substrate comprising: a) combining a matrix polymer having a melting point of about 100°C or lower with a bioactive agent selected from the group consisting of heparin, chlorhexidine, a salt of chlorhexidine, benzalkonium chloride and methyl paraben; b) melt compounding said polymer and agent within the temperature range between said melting point and the decomposition point of said agent to give a homogeneous composition; and c) extrusion coating said composition onto the surface of a shaped polymeric substrate at a temperature within said range.
References Cited (Backward Citations)
No citation records indexed.
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