EP0468527A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and prevention thereof as vaccines
Assignee: United Biomedical Inc
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Filing: 1991-07-26
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Granted: —
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Expires: 2011-07-26
Abstract
Abstract 57 The present invention relates to peptides which are immunoreactive to antibodies to HCV or NANBHV and a method of detecting the presence of HCV or NANBHV antibodies in body fluids by using the peptides as the antigen. The peptides are selected from both the envelope and non-structural protein regions of the HCV or NANBHV. The detection method includes enzyme linked immunosorbent assay or other immunoassay procedures. The peptides and conjugates or polymers thereof are also useful as immunogens in generating high titer antibodies to HCV or in vaccines.
Inventors
- 👤 Yi Wang Chang
- 👤 Barbara Hosein
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 09:55
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61P; A61P1/00; A61P1/16; C07K16/00; C07K16/08; C07K16/10; C07K16/116; C07K16/118; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56983; G01N33/56988; A61K; A61K39/00; C07K2317/00; C07K2317/30; C07K2317/34; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24222
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
33 words
A peptide composition comprising a peptide having an amino acid sequence selected from the group consisting of: wherein X is -OH or -NH 2 , and analogues, segments, mixtures, conjugates and polymers thereof.
Claim 2
Dependent Claim
33 words
A peptide composition comprising a peptide having an amino acid sequence selected from the group consisting of: wherein X is -OH or -NH 2 , and analogues, segments, mixtures, conjugates and polymers thereof.
Claim 3
Dependent Claim
26 words
A peptide composition according to claim 1 wherein the peptide comprises: wherein X is -OH or -NH 2 , and analogues, segments, conjugates and polymers thereof.
Claim 4
Dependent Claim
26 words
A peptide composition according to Claim 1 wherein the peptide comprises: wherein X is -OH or -NH 2 , and analogues, segments, conjugates and polymers thereof.
Claim 5
Dependent Claim
26 words
A peptide composition according to Claim 1 wherein the peptide comprises: wherein X is -OH or -NH 2 , and analogues, segments, conjugates and polymers thereof.
Claim 6
Dependent Claim
26 words
A peptide composition according to Claim 1 wherein the peptide comprises: wherein X is -OH or -NH 2 , and analogues, segments, conjugates and polymers thereof.
Claim 7
Dependent Claim
29 words
A peptide composition comprising a mixture of Peptides VIIIE and pep11 wherein Peptide VIIIE is: and pep11 is: wherein X is -OH or NH 2 , and analogues thereof.
Claim 8
Dependent Claim
29 words
A peptide composition comprising a mixture of Peptides VIIIE and pep11 wherein Peptide VIIIE is: and pep11 is: wherein X is -OH or NH 2 , and analogues thereof.
Claim 9
Dependent Claim
25 words
A peptide composition according to claim 6 further comprising Peptide IIH having an amino acid sequence: wherein X -OH or -NH 2 and analogues thereof.
Claim 10
Dependent Claim
26 words
A peptide composition according to Claim 6 further comprising pep8 having an amino acid sequence: wherein X is -OH or -NH 2 , and analogues thereof.
Claim 11
Dependent Claim
25 words
A peptide composition according to Claim 6 further comprising pep12 having an amino acid sequence: wherein X is -OH or -NH 2 and analogues thereof.
Claim 12
Dependent Claim
29 words
A peptide composition comprising a mixture of Peptides VIIIE and pep8 wherein Peptide VIIIE is and pep8 is: and wherein X is -OH or -NH 2 and analogues thereof.
Claim 13
Dependent Claim
29 words
A peptide composition comprising a mixture of Peptides VIIIE and pep8 wherein Peptide VIIIE is and pep8 is: and wherein X is -OH or -NH 2 and analogues thereof.
Claim 14
Dependent Claim
32 words
A peptide composition according to Claim 1 comprising a mixture of pep7 and pep8, wherein pep7 is: and pep8 is: and wherein X is -OH or -NH 2 , and analogues thereof.
Claim 15
Dependent Claim
31 words
A peptide composition according to Claim 1 comprising a mixture of pep1 and pep10, wherein pep1 is: pep10 is: and wherein X is -OH or -NH 2 , and analogues thereof.
Claim 16
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 1 in an immunoassay procedure.
Claim 17
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 6 in an immunoassay procedure.
Claim 18
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 7 in an immunoassay procedure.
Claim 19
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 8 in an immunoassay procedure.
Claim 20
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 9 in an immunoassay procedure.
Claim 21
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using on effective amount of a peptide composition according to Claim 10 in an immunoassay procedure.
Claim 22
Dependent Claim
31 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of a peptide composition according to Claim 11 in an immunoassay procedure.
Claim 23
Dependent Claim
30 words
A method of detecting antibodies to HCV or diagnosis of HCV infection or NANBH by using an effective amount of peptide composition according to Claim 12 in an immunoassay procedure.
Claim 24
Dependent Claim
66 words
A peptide immunogen comprising a polymeric peptide selected from the group consisting of: [Peptide] 16 Lyss Lys 4 Lys 2 Lys-Y [Peptide] 8 Lys 4 Lys 2 Lys-Y [Peptide] 4 Lys 2 Lys-Y [Peptide] 2 Lys-Y wherein Y is -OH 2 , -NH 2 or amino acid with no side chain functional group and the peptide is selected from the group consisting of: and analogues thereof.
Claim 25
Dependent Claim
66 words
A peptide immunogen comprising a polymeric peptide selected from the group consisting of: [Peptide] 16 Lyss Lys 4 Lys 2 Lys-Y [Peptide] 8 Lys 4 Lys 2 Lys-Y [Peptide] 4 Lys 2 Lys-Y [Peptide] 2 Lys-Y wherein Y is -OH 2 , -NH 2 or amino acid with no side chain functional group and the peptide is selected from the group consisting of: and analogues thereof.
References Cited (Backward Citations)
No citation records indexed.
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