Delivery system for cyclic amino acids with improved taste, texture and compressibility

Claim 2

The delivery system of Claim 1 wherein said cyclic amino acid compound has the formula: wherein R₁ is a hydrogen atom or a lower alkyl radical and n is 4, 5 or 6; and the pharmacologically compatible salt thereof.

Claim 3

The delivery system of either of claims 1 or 2, wherein said cyclic amino acid compound is selected from the group consisting of 1-aminomethyl-1-cyclohexane-acetic acid; ethyl-1-aminomethyl-1-cyclohexane-acetate; 1-aminomethyl-1-cycloheptane-acetic acid; 1-aminomethyl-1-cyclopentane-acetic acid; methyl 1-aminomethyl-1-cyclohexane-acetate; n-butyl 1-aminomethyl-1-cyclohexane-acetate; methyl 1-aminomethyl-1-cyclohexane-acetate; n-butyl 1-aminomethyl-1-cycloheptane acetate toluene sulfonate; 1-aminomethyl-1-cyclopentaneacetate benzene-sulfonate; and n-butyl 1-aminomethyl-1-cyclopentane-acetate.

Claim 4

The delivery system of any one of Claims 1-3, further including an excipient selected from the group consisting of carbohydrate materials, particularly monosaccharides, disaccharides, polysaccharides, partially hydrolysed starch, corn syrup, sugar alcohols, and mixtures thereof, and polyhydric alcohols, and mixtures thereof.

Claim 5

The delivery system of Claim 4, wherein said excipient is present in an amount of up to about 80% by dry weight of said core material.

Claim 6

The delivery system of any preceding Claim, wherein said first coating comprises a water-insoluble film forming polymeric material selected from the group consisting of acrylic acid and substituted acrylic acid polymers and copolymers; polysulfonic acid ester polymers; vinyl and substituted vinyl ester polymers and copolymers; cellulose ethers, their polymers and copolymers, ethylcellulose; cellulose acetate; cellulose acetate phthalate; cellulose acetate butyrate; ethylene-vinyl acetates and/or phthalates; polyvinyl alcohol; polyvinyl acetates and/or phthalates; and ethyl and/or methyl methacrylic acids, esters, and copolymers, ethylcellulose; an anionic copolymer based on polymethacrylic and acrylic acid ester; a neutral copolymer based on poly(meth)acrylic acid esters; and, a cationic copolymer based on dimethylaminoethyl methacrylate and neutral methacrylic acid esters; and mixtures thereof.

Claim 7

The delivery system of any one of Claims 1-5, wherein said first coating comprises a water-soluble film-forming polymeric material.

Claim 8

The delivery system of Claim 1, wherein said first coating comprises a hydrocolloid selected from the group consisting of gums, pectins, alginates, mucilages, and mixtures thereof, preferably gum arabic, tragacanth, karaya, ghatti, agar, alginates, carrageenans, fucellan, psyllium, and mixtures thereof, and polyvinyl pyrrolidone, gelatin, dextran, xanthan, curdan, cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxymethyl cellulose, low methoxy pectin, propylene glycol alginate, and mixtures thereof.

Claim 9

The delivery system of any preceding Claim, wherein said first coating is present in an amount of from about 10% to about 25% by dry weight, and wherein said second coating is present in an amount of from about 20% to about 100% by dry weight.

Claim 10

The delivery system of any preceding Claim, wherein said first coating is present in an amount of 25% by dry weight, and said second coating is present in an amount of 50% by dry weight.

Claim 11

The delivery system of any preceding Claim, wherein the fat material is: a) a fatty acid comprised by hydrogenated or partially hydrogenated oils which are selected from the group consisting of palm oil, palm kernel oil, soybean oil, rapeseed oil, rice bran oil, cottonseed oil, sunflower oil, safflower oil, and mixtures thereof, or b) a material selected from the group consisting of monoglycerides, diglycerides, triglycerides, polyglycerol esters, sorbitol esters, and mixtures thereof.

Claim 12

The delivery system of any preceding Claim, wherein the wax material is selected from the group consisting of natural waxes, synthetic waxes and mixtures thereof, preferably paraffin wax, beeswax, carnauba wax, candelilla wax, lanolin wax, bayberry wax, sugar cane wax, petrolatum, carbowax, spermaceti wax, rice bran wax, microcrystalline wax, and mixtures thereof.

Claim 13

The delivery system of any preceding Claim, when incorporated into a composition selected from the group consisting of chewing gum compositions, confectionery compositions, pharmaceutical compositions, and chewable tablets.