EP0454886A1
Expired / Lapsed
EP
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An improved method and apparatus for measurement of oxygen concentration
Assignee: FOxS Labs
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Filing: 1990-05-02
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Granted: —
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Expires: 2010-05-02
Abstract
Abstract The method and material for measuring oxygen concentration use indicators, namely polynuclear aromatics, or more specifically, perylene derivatives, together with an appropriate matrix, such as crosslinked polydimethylsiloxane to provide a sensor element for insertion in the blood stream, preferably by means of an appropriate catheter system. By irradiating the resulting matrix with light of a specific wavelength or wavelength range, which may or may not be the wavelength of maximum absorption, while measuring the fluorescent emission over at least two other specific wavelength ranges, different portions of the emission spectrum have been observed to have different sensitivities to oxygen quenching.
Inventors
- 👤 George A. Iii Divers
- 👤 Henri K. Hui
- 👤 Amos Gottlieb
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 10:19
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N21/643; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; G01N2021/6417; G01N21/645; G01N2021/6484; Y; Y10; Y10T; Y10T436/00; Y10T436/20; Y10T436/207497; Y10T436/209163; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
121 words
An analyte sensing apparatus which comprises; a species which produces an output when exposed to external excitation, said output varying as a function of the concentration of an analyte exposed to said species, said species further including a variation in output as a function of the frequency of said output when said species is exposed to a given concentration of said analyte; means to constrain a quantity of said species, said constraining means further providing means to expose at least a portion of said species to said analyte; means to excite said species; means to measure the output of said species at a plurality of frequencies of said output; and means to derive the concentration of said analyte from said measurements.
Claim 2
Dependent Claim
27 words
The analyte sensing apparatus of Claim 1 wherein said means to constrain said species includes an analyte permeable matrix in which said species is immobilized or dispersed.
Claim 3
Dependent Claim
29 words
The analyte sensing apparatus of Claims 1 or 2 wherein the species is polynuclear aromatic hydrocarbon based fluorescent dye selected from group consisting essentially of perylene and derivatives thereof.
Claim 4
Dependent Claim
15 words
The analyte sensing apparatus of any one of Claims 1-3 wherein said species is coronene.
Claim 5
Dependent Claim
21 words
The analyte sensing apparatus of any one of Claims 1-3 wherein said species is naphtho [8, 1, 2 - abc) coronene.
Claim 6
Dependent Claim
17 words
The analyte sensing apparatus of any one of Claims 2-5 in which said matrix is crosslinked polydimethylsiloxane.
Claim 7
Dependent Claim
22 words
The analyte sensing apparatus of any one of Claims 2-5 in which said matrix is a crosslinked derivative or copolymer of polydimethylsiloxane.
Claim 8
Dependent Claim
19 words
The analyte sensing apparatus of any one of Claims 1-7 in which said analyte to be sensed is oxygen.
Claim 9
Dependent Claim
21 words
The analyte sensing apparatus of any one of Claims 1-7 in which said analyte to be sensed is an anesthetic agent.
Claim 10
Independent Claim
76 words
A method of sensing the concentration of analyte in a fluid medium which comprises: exposing a sample of an indicator which displays a variation in output as a function of frequency when exposed to an analyte, to said fluid; activating said indicator with radiation; measuring the output of said indicator at a plurality of frequencies; and determining the concentration of said analyte on the basis of the ratio of said plurality of outputs of said indicator.
Claim 11
Independent Claim
38 words
The method of Claims 10 wherein the indicator consists of a polynuclear aromatic hydrocarbon based fluorescent dye selected from the group consisting essentially of perylene, and derivatives thereof, said indicator dispersed or immobilized in an analyte permeable matrix.
Claim 12
Independent Claim
12 words
The method of Claims 10 or 11 wherein the dye is coronene.
Claim 13
Independent Claim
14 words
The method of Claims 10 or 11 wherein the dye is naphtho [8,1,2-abc] coronene.
Claim 14
Independent Claim
16 words
The method of any one of Claims 10-13 wherein the analyte permeable matrix is crosslinked polydimethylsiloxane.
Claim 15
Independent Claim
21 words
The method of any one of Claims 10-13 wherein the analyte permeable matrix is a crosslinked derivative or copolymer of polydimethylsiloxane.
Claim 16
Independent Claim
16 words
The method of any one of Claims 10-15 wherein the analyte to be sensed is oxygen.
Claim 17
Independent Claim
18 words
The method of any one of Claims 10-15 wherein the analyte to be sensed is an anesthetic agent.
Claim 18
Independent Claim
88 words
An apparatus for sensing the concentration of analyte in a fluid medium which comprises: (a) means for exposing a sample of an indicator which displays a variation in output as a function of frequency when exposed to an analyte, to said fluid; (b) means for activating said indicator with radiation; (c) means for measuring the output of said indicator at a plurality of frequencies; and (d) means for determining the concentration of said analyte on the basis of the ratio of said plurality of outputs of said indicator.
References Cited (Backward Citations)
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