EP0452926A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1991-04-18
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Granted: —
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Expires: 2011-04-18
Abstract
Abstract This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by 5(R n -phenyl)-4-alkyl-3H-1,2,4-triazole-3-thiones of the formula wherein R is halogen, trifluoromethyl, C₁₋₄ lower alkyl or C₁₋₄ lower alkoxy, n is zero, 1 or 2, and R₂ represents hydrogen or C₁₋₃ lower alkyl; and R₄ independently represents C₁₋₃ lower alkyl .
Inventors
- 👤 Jerry A. Miller
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 03:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61P; A61P25/00; A61P25/28
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
53 words
Use of a compound of the formula I wherein R is halogen, trifluoromethyl, C₁₋₄ lower alkyl or C₁₋₄ lower alkoxy; n is zero, 1 or 2; R₂ represents hydrogen or C₁₋₃ lower alkyl; and R₄ independently represents C₁₋₃ lower alkyl for the preparation of pharmaceutical compositions for the enhancement of memory and cognition.
Claim 2
Dependent Claim
9 words
The use of claim 1 wherein R is halogen.
Claim 3
Dependent Claim
9 words
The use of claim 2 wherein R is fluoro.
Claim 4
Dependent Claim
12 words
The use of claim 1 wherein R₄ and R₄ each are methyl.
Claim 5
Dependent Claim
13 words
The use of claim 4 wherein R is fluoro and n is 1.
Claim 6
Dependent Claim
17 words
The use of claim 1, said compound I being 5-(3-fluorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione, 5-(2,4-difluorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione, 5-(4-fluorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione, 5-(2-fluorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione, 5-phenyl-2,4-dimethyl-3H-1,2,4-triazole-3-thione, 5-phenyl-4-methyl-3H-1,2,4-triazole-3-thione, or 5-(2,6-difluorophenyl)-2,4-dimethyl-3H-1,2,4-triazole-3-thione.
Claim 7
Dependent Claim
25 words
Use of compounds I according to any of claims 1 to 6 for the preparation of a pharmaceutical composition for the treatment of Alzheimer's disease.
Claim 8
Dependent Claim
25 words
Use of compounds I according to any of claims 1 to 6 for the preparation of a pharmaceutical composition for the treatment of Wernicke-Korsakoff syndrome.
References Cited (Backward Citations)
No citation records indexed.
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