EP0439318A2
Expired / Lapsed
EP
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Doped sol-gel glasses for obtaining chemical interactions
Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1991-01-22
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Granted: —
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Expires: 2011-01-22
Abstract
Abstract A method for obtaining an interaction between reagent/s in a solid support and diffusible solute/s or components in an adjacent liquid or gas phase wherein said reagent/s are trapped in a sol-gel glass (hereinafter also referred to as doped sol gel glass) which provides the solid support to the reagents, wherin a sol-gel glass is any ceramic or organoceramic material prepared by polymerization of suitable monomers, such as metal alkoxide mixtures, wherein the polymerization is carried out through the sol gel-xerogel stages.
Inventors
- 👤 David Avnir
- 👤 Sergei Brown
- 👤 Michael Ottolenghi
- 👤 Rivka Zusman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 04:35
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6863; G01N33/6869; B; B01; B01J; B01J20/00; B01J20/281; B01J20/282; B01J20/283; B01J20/291; C; C03; C03C; C03C4/00; C03C4/0007; C12; C12N; C12N11/00; C12N11/14; C12P; C12P1/00; G01N31/00; G01N31/22; G01N33/53; G01N33/543; G01N33/5436; G01N33/551; G01N33/552; G01N33/84; B01J2220/00; B01J2220/50; B01J2220/54; G01N30/00; G01N30/02; G01N30/90; G01N30/92; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989; Y10T436/00; Y10T436/10
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
83 words
1) A method for obtaining an interaction between reagent/s in a solid support and diffusible solute/s or components in an adjacent liquid or gas phase wherein said reagent/s are trapped in a sol-gel glass (hereinafter also referred to as doped sol gel glass) which provides the solid support to the reagents, wherin a sol-gel glass is any ceramic or organoceramic material prepared by polymerization of suitable monomers, such as metal alkoxide mixtures, wherein the polymerization is carried out through the sol gel-xerogel stages.
Claim 2
Dependent Claim
83 words
1) A method for obtaining an interaction between reagent/s in a solid support and diffusible solute/s or components in an adjacent liquid or gas phase wherein said reagent/s are trapped in a sol-gel glass (hereinafter also referred to as doped sol gel glass) which provides the solid support to the reagents, wherin a sol-gel glass is any ceramic or organoceramic material prepared by polymerization of suitable monomers, such as metal alkoxide mixtures, wherein the polymerization is carried out through the sol gel-xerogel stages.
Claim 3
Dependent Claim
35 words
2) A method according to claim 1 wherein said reagent/s are any organic and/or stable organic radical/s and/or organometallic and/or inorganic compounds and/or material of biological origin, capable of being trapped in said sol-gel glasses.
Claim 4
Dependent Claim
37 words
3) A method according to claim 1 wherein said diffusible solute/s or components are any organic and/or stable organic radical/s and/or organometallic and/or inorganic compound and/or material of biological origin, capable of interacting with the trapped reagents.
Claim 5
Dependent Claim
38 words
4) A method according to claims 1-3 wherein a sol-gel glass support is deposited on, coated or mixed with other material, such as fibers, polymeric matrices, metals, glass or other organic and inorganic surfaces, or prepared by co-polymerization.
Claim 6
Dependent Claim
20 words
5) A method according to claim 1-4 wherein said interaction is a chemical interaction for synthesis, for adsorption, for chemisorption.
Claim 7
Dependent Claim
30 words
6) A method according to claim 5 wherein said chemical interaction is an analytical test for detection or quantitative determination of any organic, inorganic or metalloorganic compound, ion or radical.
Claim 8
Dependent Claim
41 words
7) A method according to claim 6 wherein said chemical interaction takes place between solute/s in a liquid phase or components in a gas phase with analytical reagent/s trapped in the sol gel glass, or vice versa, via characteristic color-test reactions.
Claim 9
Dependent Claim
25 words
8) A method according to claims 1-7 for analytical purposes using any known analytical method including absorption or emission of electromagnetic radiation, N.M.R. and E.S.R.
Claim 10
Dependent Claim
20 words
9) A method according to claims 1-8 for the analysis of ore contents in earth, rock or water (e.g. uranium).
Claim 11
Dependent Claim
16 words
10) A method according to claim s 1-7 wherein the analytical reagent is a pH indicator.
Claim 12
Dependent Claim
30 words
11) A method according to claims 1-9 for the determination of Fe²⁺, Al³⁺, Co²⁺, Ni²⁺, SO₄²⁻ and Cu²⁺ ions using sol-gel glass doped with a reagent specific for each ion/s.
Claim 13
Dependent Claim
38 words
12) A method according to claims 1-11 wherein the sol-gel glass is in the shape of rods, sieves or any other shape or thin films of sol-gel glasses coating conventional glass plates, metal or any other solid support.
Claim 14
Dependent Claim
25 words
13) A method according to claim 12 wherein an electrochemical test is performed by preparing electrodes or enzyme electrodes coated with doped sol-gel glass layers.
Claim 15
Dependent Claim
27 words
14) A method according to claim 13 wherein said electrodes are piezoelectric electrodes or any other electrodes for clinical and/or analytical and/or industrial use or as biosensors.
Claim 16
Dependent Claim
16 words
15) A method according to claim 1-4 for extracting or separating molecular solutes from liquid solutions.
Claim 17
Dependent Claim
31 words
16) A method according to claim 15 wherein the doped sol gel glasses are for all chromatographic purposes including liquid, gas and thin layer chromatography, and including cation and/or anion exchangers.
Claim 18
Dependent Claim
36 words
17) A method according to claims 1-16 for qualitative and/or quantitative analysis of pollutants in food, drugs, air, soil or aquatic environments and characteristic water sources, including waste, industrial and municipal sources, lakes and swimming pools.
Claim 19
Dependent Claim
23 words
18) A method according to claim 17 wherein the pollutants are chlorides, nitrates, phosphate, herbicides, insecticides, inorganic ions; and pollutants of organic origin.
Claim 20
Dependent Claim
13 words
19) A method according to claims 17, 18 including monitors for food degradation.
Claim 21
Dependent Claim
31 words
20) A method according to claims 1-14 for detecting inorganic ions and/or small organic molecules and/or other components in blood, urine and other body liquids for the purpose of medical diagnostic.
Claim 22
Dependent Claim
46 words
21) A method according to claims 1-5 wherein said interaction is between enzymes with or without a co-enzyme or other co-factors in the liquid phase and a doped substrate such as immunoglobulins, antigens, or other chemical or biochemical species trapped in the sol-gel glasses, or vice-versa.
Claim 23
Dependent Claim
28 words
22) A method according to claim 21 wherein said enzyme/s are any material of microbial, animal or plant origin displaying enzymatic activity and essentially free of viable cells.
Claim 24
Dependent Claim
28 words
23) A method according to claims 21-22, wherein entrapment of the protein in the forming sol-gel is carried out in the presence of a solvent or an additive.
Claim 25
Dependent Claim
28 words
24) A method according to claims 21-23 wherein the enzyme catalyst is used to carry out a chemical reaction in liquid organic/inorganic solvent or in a gas phase.
Claim 26
Dependent Claim
27 words
25) A method according to claims 21-24, wherein the enzyme is a hydrolase (e.g. trypsin, alkaline or acid phosphatase, chitinase, lipase, lactase, aminoacylase, penicillin or cephalosporin acylase).
Claim 27
Dependent Claim
15 words
26) A method according to claims 21-24, wherein the enzyme is a lyase (e.g. aspartase).
Claim 28
Dependent Claim
17 words
27) A method according to claims 21-24, wherein the enzyme is an oxidoreductase (e.g. peroxidase, glucose oxidase).
Claim 29
Dependent Claim
14 words
28) A method according to claims 21-23 wherein said interaction is for hormonal tests.
Claim 30
Dependent Claim
33 words
29) A method according to claims 21-23 wherein the interaction is between the glass trapped antibody and its diffusible antigen (e.g. monoclonal antibody against interleukin-2 receptor and the interleukin-2 receptor) or vice versa.
Claim 31
Dependent Claim
31 words
30) A method according to claims 1-5 wherein the sol gel glasses are used as active specific membranes allowing selective incorporation of the trapped molecules or ions or any other species.
Claim 32
Dependent Claim
24 words
31) A method according to claims 1-5 wherein a doped sol contains a reagent for organic synthesis, such as redox reagent, acid-base catalyst etc.
Claim 33
Dependent Claim
14 words
32) A doped sol gel glass for utilizing the method according to claims 1-31.
Claim 34
Dependent Claim
35 words
33) A doped sol gel glass according to claim 32 wherein said glass is prepared as a thin film forming molecular monolayers to macroscopic layers, or forming a part of an array of thin films.
Claim 35
Dependent Claim
23 words
34) A doped sol gel glass according to claim 33 wherein said thin film is supported on a solid support, including optical material.
Claim 36
Dependent Claim
23 words
35) A doped sol gel glass according to claim 32 wherein said glass, dry or colloid, is produced by any suitable polymerization process.
Claim 37
Dependent Claim
18 words
36) A doped sol gel glass according to claim 32 wherein said glass is prepared as thin sieves.
Claim 38
Dependent Claim
25 words
37) A doped sol gel glass according to claim 32 in which more than one analytical reagent is trapped, forming a multiple purpose analytical glass.
Claim 39
Dependent Claim
25 words
38) A doped sol gel glass according to claims 32-37 wherein the distribution of the doped reagent/s is not homogeneous, but follows a predetermined gradient.
Claim 40
Dependent Claim
23 words
39) A doped sol gel glass according to claims 32-38 wherein said glass is designed to be swallowed or implanted in the body.
Claim 41
Dependent Claim
90 words
40) A process for the preparation of the sol-gel glass for the purpose of utilizing the method according to claim 1 wherein metal alkoxides, semi-metal alkoxides, metal esters and semi-metal esters monomers of the formula M(R) n (P)m in which M is a metallic and/or semi-metalic element, R is a hydrolyzable substituent, n is an integer between 1-6, P ia a non-polymerizable substituents and m is an integer between 0-6, are polymerized or co-polymerized with an organic polymer under acidic, neutral or basic conditions resulting in a transparent porous xerogel.
Claim 42
Dependent Claim
33 words
41) A process according to claim 40 wherein M is Si and/or Al and/or Ti and/or Pb, R is alkyl and/or aryl and/or alkoxy and/or aryloxy and n is 2, 3 or 4.
Claim 43
Dependent Claim
24 words
42) A process according to claims 40 and 41 wherein the sol-gel glass is a composite of two or more of the M(R)n monomers.
Claim 44
Dependent Claim
40 words
43) A process for the preparation of the doped sol gel glass for utilizing the method according to claim 1 wherein the dopant/s are trapped in the glass by adding a solution containing the dopant/s to the starting polymerizing system.
Claim 45
Dependent Claim
13 words
44) A method according to claims 1-43 substantially as described and exemplified above.
Claim 46
Dependent Claim
16 words
45) A doped sol gel glass according to claims 1-43 substantially as described and exemplified above.
References Cited (Backward Citations)
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