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EP0426486A2
Expired / Lapsed
EP
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Anti-thromobogenic, and/or anti-microbial composition
Assignee: Angiotech Biocoatings Corp
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Filing: 1990-11-02
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Granted: —
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Expires: 2010-11-02
Abstract
Abstract Anti-thrombogenic, anti-microbial compositions containing heparin, and/or antibiotics or other pharmaceutical agents reacted with quaternary ammounium components or other ionic surfactants and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds or other ionic surfactants not reacted with heparin and may also contain quaternary ammonium compound(s) or other ionic surfactants reacted with antiobiotics or other ionic phaarmaceutical agents.
Inventors
- 👤 Richard James Whitbourne
- 👤 Margaret Anne Mangan
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:47
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L33/0023; A61L33/0029; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/208; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45; A61L2300/80; A61L2300/802
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
60 words
A composition comprising a mixture of a first component which comprises at least one of (a) heparin reacted with a quaternary ammonium compound, (b) an ionic antibiotic agent reacted with a ionic organic surfactant or ionic macromolecule, and (c) an ionic pharmaceutical agent reacted with an ionic organic surfactant or ionic macromolecule, and a second component comprising a water-insoluble polymer.
Claim 2
Dependent Claim
60 words
A composition comprising a mixture of a first component which comprises at least one of (a) heparin reacted with a quaternary ammonium compound, (b) an ionic antibiotic agent reacted with a ionic organic surfactant or ionic macromolecule, and (c) an ionic pharmaceutical agent reacted with an ionic organic surfactant or ionic macromolecule, and a second component comprising a water-insoluble polymer.
Claim 3
Dependent Claim
35 words
A composition according to claim 1, in which the water-insoluble polymer is at least one of a cellulose ester, a polyurethane resin, an acrylic polymer, a condensation polymer, an aldehyde condensation polymer and a polyisocyanate.
Claim 4
Dependent Claim
36 words
A composition according to claim 1, in which the water-insoluble polymer is at least one of nitrocellulose, cellulose acetate butyrate, cellulose acetate propionate, an acrylic resin, a polyurethane resin, a polyisocyanate resin, and a condensation polymer.
Claim 5
Dependent Claim
40 words
A composition according to any preceding claim, in which the first component comprises (a) and the composition has anti-thrombogenic properties, the quaternary ammonium compound being at least one of benzalkonium chloride, tridodecylmethylammonium chloride, cetylpyridinium chloride, benzyldimethylstearylammonium chloride and benzylcetyldimethylammonium chloride.
Claim 6
Dependent Claim
15 words
A composition according to claim 4, in which the quaternary ammonium compound is benzalkonium chloride.
Claim 7
Dependent Claim
25 words
A composition according to claim 4 or 5, in which (a) is present in a concentration of at least 0.5% by weight of the composition.
Claim 8
Dependent Claim
30 words
A composition according to claim 6, in which (a) is present in a concentration of 0.5% to 99.5% by weight of the composition with the balance being the water-insoluble polymer.
Claim 9
Dependent Claim
28 words
A composition according to any of claims 4 to 6, which the first component also contains (b) in which the ionic organic surfactant comprises a quaternary ammonium compound.
Claim 10
Dependent Claim
50 words
A composition according to any of claims 1 to 3, in which the first component comprises (b) and the composition has antimicrobial properties, the antibiotic agent being negatively charged and comprising one or more of penicillin, ticarcillin, cefotoxin, a cephalorsporin, oxacillin and carbonicillin, the surfactant being a quaternary ammonium compound.
Claim 11
Dependent Claim
30 words
A composition according to claim 9, in which (b) is present in a concentration of 0.5% to 99.5% by weight of the composition with the balance being the water-insoluble polymer.
Claim 12
Dependent Claim
32 words
A composition according to any of claims 8 to 10 in which the quaternary ammonium compound is at least one of benzalkonium chloride, tridodecylmethylammonium chloride, cetylpyridinium chloride, benzyldimethylstearylammonium chloride and benzylcetyldimethylammonium chloride.
Claim 13
Dependent Claim
38 words
A composition according to any of claims 1 to 3, in which the first component comprises (b) and the composition has anti-microbial properties, the antibiotic agent being positively charged and the surfactant having a negatively charged organic ion.
Claim 14
Dependent Claim
28 words
A composition according to claim 10, in which the surfactant comprises sodium lauryl sulphate, or stearic acid or a salt thereof or polyacrylic acid or a copolymer thereof.
Claim 15
Dependent Claim
32 words
A composition according to any of claims 8 to 13, in which (b) and the water-insoluble polymer are each present in a concentration of 0.01% to 40% by weight of the composition.
Claim 16
Dependent Claim
18 words
A composition according to any preceding claim, in which the first and second components are in separate layers.
Claim 17
Independent Claim
74 words
A method of forming a coating on the surface of a medical device to be brought into contact with human or animal body fluids, the method comprising (a) forming a coating solution which comprises a composition according to any of claims 1 to 14 and a co-solvent for the first and second components of the composition, (b) applying the coating solution to the surface of the device, and (c) allowing the solution to dry.
Claim 18
Independent Claim
72 words
A method of forming a coating on the surface of a medical device to be brought into contact with human or animal body fluids, the method comprising (a) forming respective coating solutions comprising the first and the second components of a composition according to any of claims 1 to 14 and respective solvents, (b) applying the coating solutions separately to the surface of the device, and (c) allowing the solutions to dry.
Claim 19
Independent Claim
78 words
A method of forming a coating on the surface of a water-insoluble polymer, the method comprising (a) forming a coating solution which comprises the first component of a composition according to any of claims 1 to 14 and a solvent for the first component, (b) applying the coating solution to a surface of a water-insoluble polymer comprising the second component of a composition according to any of claims 1 to 14, and (c) allowing the solution to dry.
Claim 20
Independent Claim
32 words
A method according to any of claims 16 to 18, in which the concentration of the first component in its respective coating solution is 0.01% to 20% by weight of the solution.
Claim 21
Dependent Claim
30 words
A method according to claim 16 or 17, in which the concentration of the second component in its respective coating solution is 0.1% to 20% by weight of the solution.
Claim 22
Dependent Claim
43 words
A medical device having at least a portion of its surface coated with the first component of a composition according to any of claims 1 to 14 bound with the second component of a composition according to any of claims 1 to 14.
References Cited (Backward Citations)
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