Bispecific and oligospecific, mono- and oligovalent receptors, production and applications thereof

Abstract

Abstract The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by genetic manipulation by fusion of DNA coding for F(ab) fragments of the antibodies of two or more different specificities, using suitable linkers. Preferably one of these specificities is directed against an epitope, which is located either on the cell membrane or in the interstitium, of a tumour-associated antigen (TAA) while the other specificities relate to high molecular or low molecular weight ligands and react, for example, with the complexons ethylenediaminetetraacetate or diethylenetriaminepentaacetate in Y90-complexed form (EDTA-Y90 or DTPA-Y90). In a particularly preferred embodiment, the binding to the complexons takes place on the complexon-receptor arm via fos-jun interaction (or else avidin-biotin interaction). Further preferred specificities have catalytic properties.

Inventors

• 👤 Klaus Dr. Bosslet
• 👤 Peter Dr. Hermentin
• 👤 Gerhard Dr. Seemann
• 👤 Ludwig Dr. Kuhlmann
• 👤 Axel Dr. Dr. Steinsträsser

Bibliographic Details