EP0403650A1
Expired / Lapsed
EP
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Medical material permitting cells to enter thereinto and artificial skin
Assignee: Terumo Corp
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Filing: 1989-03-09
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Granted: —
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Expires: 2009-03-09
Abstract
Abstract A medical material permitting cells to enter thereinto which contains modified collagen including 0 to 80% of helix and a carrier showing a higher resistance against enzymatic decomposition than the collagen is disclosed. An artificial skin using this medical material as a wound-contacting layer and a process adapted for producing it are also disclosed.
Inventors
- 👤 Katsutoshi Yoshisato
- 👤 Jun Terumo Kabushiki Kaisha 2656-1 Konishi
- 👤 Mikio Terumo Kabushiki Kaisha 2656-1 Koide
- 👤 Kaoru Terumo Kabushiki Kaisha 2656-1 Oyamada
- 👤 Kenichi Terumo Kabushiki Kaisha 2656-1 Ohsaki
- 👤 Takeo Terumo Kabushiki Kaisha 2656-1 Katakura
- 👤 Yuichi Mori
- 👤 Ken Terumo Kabushiki Kaisha 2656-1 Tatebe
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 14:28
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3695; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/60; C; C12; C12N; C12N5/00; C12N5/0062; C12N5/0068; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
29 words
1 . A cell-penetrable medical material, comprising denatured collagen with helix content of 0 to 80%, and carrier substance possessing higher resistance to enzyme decomposition than the denatured collagen.
Claim 2
Dependent Claim
29 words
1 . A cell-penetrable medical material, comprising denatured collagen with helix content of 0 to 80%, and carrier substance possessing higher resistance to enzyme decomposition than the denatured collagen.
Claim 3
Dependent Claim
21 words
A medical material of claim 1, wherein the denatured collagen lacks an antigenic portion at a terminal of the collagen molecule.
Claim 4
Dependent Claim
25 words
A medical material of claim 1, wherein the carrier substance is selected from a group consisting of collagen, fibroin, polylactic acid, mucopolysaccharide, and arginic acid.
Claim 5
Dependent Claim
13 words
A medical material of claim 3, wherein the carrier substance is undenatured collagen.
Claim 6
Dependent Claim
26 words
5 . A medical material of claim 3, wherein the carrier substance is a collagen lacking of an antigenic portion at a terminal of the molecule.
Claim 7
Dependent Claim
16 words
A medical material of claim 3, wherein the carrier substance is a collagen with crosslinking structure.
Claim 8
Dependent Claim
13 words
A medical material of claim 3, wherein the carrier substance is fibrous collagen.
Claim 9
Dependent Claim
14 words
A medical material of claim 7, wherein the fibrous collagen has a crosslinking structure.
Claim 10
Dependent Claim
14 words
A medical material of claim 1, wherein the form is in a film shape.
Claim 11
Dependent Claim
16 words
A medical material of claim 9, wherein the carrier substance is dispersed in the denatured collagen.
Claim 12
Dependent Claim
14 words
A medical material of claim 1, wherein the form is in a sponge shape.
Claim 13
Dependent Claim
26 words
A medical material of claim 11, wherein the carrier substance is formed in a spongy matrix, and the denatured collagen is contained in the spongy matrix.
Claim 14
Dependent Claim
22 words
A medical material of claim 1, wherein the ratio of denatured collagen to the carrier substance is about 5 to 80% (w/v).
Claim 15
Dependent Claim
60 words
An artificial skin comprising a support layer composed of fibroin, a wound contact layer laminated on one side of the support layer, and a moisture permeation regulating layer for controlling the moisture permeation laminated on the other side of the support layer, wherein the wound contact layer contains denatured collagen with helix content of 0 to 80%, and fibrous collagen.
Claim 16
Dependent Claim
60 words
An artificial skin comprising a support layer composed of fibroin, a wound contact layer laminated on one side of the support layer, and a moisture permeation regulating layer for controlling the moisture permeation laminated on the other side of the support layer, wherein the wound contact layer contains denatured collagen with helix content of 0 to 80%, and fibrous collagen.
Claim 17
Dependent Claim
21 words
An artificial skin of claim 14, wherein the fibrous collagen lacks an antigenic portion at a terminal of the collagen molecule.
Claim 18
Dependent Claim
18 words
1 6. An artificial skin of claim 14, wherein the form of the wound contact layer is sponge.
Claim 19
Dependent Claim
21 words
An artificial skin of claim 14, wherein the fibrous collagen is dispersed in the denatured collagen, in the wound contact layer.
Claim 20
Dependent Claim
31 words
An artificial skin of claim 14, wherein the carrier substance is formed in a spongy matrix and the denatured collagen is contained in the spongy matrix, in the wound contact layer.
Claim 21
Dependent Claim
22 words
An artificial skin of claim 14, wherein the fibroin for composing the support layer is a nonwoven porous body insoluble in water.
Claim 22
Dependent Claim
31 words
An artificial skin of claim 14, wherein the moisture permeation regulating layer is composed of nontoxic substance selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester, and polyurethane.
Claim 23
Dependent Claim
24 words
An artificial skin of claim 14, wherein the moisture permeation regulating layer has a moisture flux of about 0.1 to 1 mg/cm 2 /hr.
Claim 24
Dependent Claim
32 words
22 . An artificial skin of claim 1 4 , wherein an antibacterial agent is incorporated into at least one layer of wound contact layer, support layer and moisture permeation regulating layer.
Claim 25
Dependent Claim
23 words
An artificial skin of claim 22, wherein the antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
Claim 26
Dependent Claim
64 words
An artificial skin comprising a support layer made of fibrous collagen with crosslinking structure, a wound contact layer laminated on one side of the support layer, and a moisture permeation regulating layer for controlling the moisture permeation laminated on the other side of the support layer, wherein the would contact layer comprises denatured collagen with helix content of 0 to 80% and fibrous collagen.
Claim 27
Dependent Claim
64 words
An artificial skin comprising a support layer made of fibrous collagen with crosslinking structure, a wound contact layer laminated on one side of the support layer, and a moisture permeation regulating layer for controlling the moisture permeation laminated on the other side of the support layer, wherein the would contact layer comprises denatured collagen with helix content of 0 to 80% and fibrous collagen.
Claim 28
Dependent Claim
20 words
An artificial skin of claim 24, wherein the fibrous collagen lacks an antigenic portion at terminal of the collagen molecule.
Claim 29
Dependent Claim
23 words
An artificial skin of claim 24, wherein the fibrous collagen with crosslinking structure lacks an antigenic portion at a terminal of collagen molecule.
Claim 30
Dependent Claim
16 words
An artificial skin of claim 24, wherein the form of the wound contact layer is sponge.
Claim 31
Dependent Claim
21 words
An artificial skin of claim 24, wherein the fibrous collagen is dispersed in the denatured collagen, in the wound contact layer.
Claim 32
Dependent Claim
31 words
An artificial skin of claim 24, wherein the carrier substance is formed in a spongy matrix and the denatured collagen is contained in the spongy matrix, in the wound contact layer.
Claim 33
Dependent Claim
19 words
An artificial skin of claim 24, wherein the fibroin for composing the support layer is a nonwoven porous body.
Claim 34
Dependent Claim
31 words
An artificial skin of claim 24, wherein the moisture permeation regulating layer is composed of nontoxic substance selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester, and polyurethane.
Claim 35
Dependent Claim
24 words
An artificial skin of claim 24, wherein the moisture permeation regulating layer has a moisture flux of about 0.1 to 1 mg/cm 2 /hr.
Claim 36
Dependent Claim
28 words
An artificial skin of claim 24, wherein an antibacterial agent is incorporated into at least one layer of wound contact layer, support layer and moisture permeation regulating layer.
Claim 37
Dependent Claim
26 words
3 4 . An artificial skin of claim 24, wherein the antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
Claim 38
Independent Claim
163 words
A method for preparation of an artificial skin comprising a step of preparing a mixed solution of denatured collagen with helix content of 0 to 80% and fibrous collagen, a step of placing a fibroin film or a fibrous collagen film with crosslinking structure on the liquid surface of the mixed solution, and then freeze-drying, thereby forming a laminate of a support layer composed of the fibroin film or fibrous collagen film, and a wound contact layer made of porous substance composed of denatured collagen and fibrillated collagen, a step of forming a viscous thin film composed of a substance for offering moisture permeable film on a substrate having a peeling surface, a step of placing the laminate so that the thin film may contact with the fibroin film or fibrillated collagen film, and a step of drying the thin film until hardened, and heating for 1 to 24 hours at 50 to 1 80°C in a vacuum of less than 0.05 Torr.
Claim 39
Independent Claim
163 words
A method for preparation of an artificial skin comprising a step of preparing a mixed solution of denatured collagen with helix content of 0 to 80% and fibrous collagen, a step of placing a fibroin film or a fibrous collagen film with crosslinking structure on the liquid surface of the mixed solution, and then freeze-drying, thereby forming a laminate of a support layer composed of the fibroin film or fibrous collagen film, and a wound contact layer made of porous substance composed of denatured collagen and fibrillated collagen, a step of forming a viscous thin film composed of a substance for offering moisture permeable film on a substrate having a peeling surface, a step of placing the laminate so that the thin film may contact with the fibroin film or fibrillated collagen film, and a step of drying the thin film until hardened, and heating for 1 to 24 hours at 50 to 1 80°C in a vacuum of less than 0.05 Torr.
Claim 40
Dependent Claim
21 words
A method of claim 35, wherein the fibroin film or fibrous collagen film with crosslinking structure is a porous spongy film.
Claim 41
Dependent Claim
40 words
A method of claim 36, wherein an antibacterial agent is incorporated into at least one of the solution containing denatured collagen and fibrillated collagen, fibroin film, fibrous collagen with crosslinking structure, and moisture permeation regulating layer of viscous thin film.
Claim 42
Dependent Claim
22 words
A method of claim 37, wherein the antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
References Cited (Backward Citations)
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