EP0402698A2
Expired / Lapsed
EP
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Leukocyte poor red blood cell storage system
Assignee: Bayer Corp
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Filing: 1990-05-30
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Granted: —
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Expires: 2010-05-30
Abstract
Abstract Closed blood bag system useful for the filtration of leukocytes from a red blood cell concentrate followed by the preparation and long term storage of neocytes and, preferably, gerocytes from the filtered concentrate. In very preferred embodiments, the system also provides containers for the expression of plasma and the preparation and long term storage of platelets.
Inventors
- 👤 Raleigh A. Carmen
- 👤 Randy B. Garcez
- 👤 Barry S. Leng
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 16:39
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0231; A61M39/00; A61M39/22; A61M39/221; A61M2039/222; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0429; A61M2202/0431; A61M2202/0439
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
102 words
A closed blood bag system for the filtration, separation and storage of red blood cells, and comprising a filter for removal of white blood cells from a mixture of white blood cells and red blood cells, the filter having (a) a first port in sterile communication with or capable of being in sterile communication with a mixture of red blood cells and white blood cells and (b) a second port in direct sterile communication with (1) a bag for separation of red blood cells into neocytes and gerocytes, and (2) at least one other bag containing a red blood cell storage solution.
Claim 2
Dependent Claim
102 words
A closed blood bag system for the filtration, separation and storage of red blood cells, and comprising a filter for removal of white blood cells from a mixture of white blood cells and red blood cells, the filter having (a) a first port in sterile communication with or capable of being in sterile communication with a mixture of red blood cells and white blood cells and (b) a second port in direct sterile communication with (1) a bag for separation of red blood cells into neocytes and gerocytes, and (2) at least one other bag containing a red blood cell storage solution.
Claim 3
Dependent Claim
18 words
The system of claim 1 wherein the second port is in direct sterile communication with a third bag.
Claim 4
Dependent Claim
19 words
The system of claim 1 wherein the first port is in direct, sterile communication with at least one bag.
Claim 5
Dependent Claim
19 words
The system of claim 1 wherein the first port is in direct, sterile communication with at least two bags.
Claim 6
Dependent Claim
17 words
The system of claim 1 wherein the first port is in direct, sterile communication with three bags.
Claim 7
Dependent Claim
29 words
The system of claim 5 wherein at least one of the bags in direct sterile communication with the first port is adapted for the long term storage of platelets.
Claim 8
Dependent Claim
25 words
The system of claim 6 wherein the bag adapted for storage of platelets is made from a plastic film having a relatively high gas transmissivity.
Claim 9
Dependent Claim
27 words
The system of claim 1 wherein the red blood cell storage solution comprises a solution suitable for storing red blood cells for at least about 42 days.
Claim 10
Dependent Claim
24 words
The system of claim 2 where the third bag contains a solution selected from a red blood cell storage solution and a saline solution.
Claim 11
Dependent Claim
36 words
The system of claim 1 wherein the bag for separation of the red blood cells into neocytes and gerocytes comprises an elongated plastic bag having a length to width ratio of at least 2 to 1.
Claim 12
Dependent Claim
17 words
The system of claim 10 wherein the length to width ratio is at least 2.5 to 1.
Claim 13
Dependent Claim
72 words
In a closed blood bag system for the collection and separation of red blood cells into neocytes and gerocytes and comprising a neocyte/gerocyte separation bag and at least one other bag in direct sterile communication with the separation bag, the improvement comprising having a filter for filtering white blood cells from a mixture of white blood cells and red blood cells, the filter being in direct, sterile communication with the separation bag.
Claim 14
Dependent Claim
72 words
In a closed blood bag system for the collection and separation of red blood cells into neocytes and gerocytes and comprising a neocyte/gerocyte separation bag and at least one other bag in direct sterile communication with the separation bag, the improvement comprising having a filter for filtering white blood cells from a mixture of white blood cells and red blood cells, the filter being in direct, sterile communication with the separation bag.
Claim 15
Dependent Claim
31 words
The system of claim 12 wherein a bag containing a saline solution or a red blood cell storage solution is in direct sterile communication with the filter and the separation bag.
Claim 16
Dependent Claim
36 words
The system of claim 12 wherein the filter includes two ports, a first port in direct sterile communication with the separation bag and a second port in direct sterile communication with at least one other bag.
Claim 17
Dependent Claim
34 words
The system of claim 12 wherein the second port is in direct sterile communication with at least two bags, one of which is made from a plastic film having a relatively high gas transmissivity.
Claim 18
Independent Claim
109 words
A method of preparing neocytes comprising the steps of (a) introducing a suspension of packed red blood cells and white blood cells into a filter having an entrance port and an exit port and capable of removing substantially all white blood cells from the suspension; (b) collecting the filtered red blood cells into a separation bag adapted to separate red blood cells into neocytes and gerocytes; (c) separating the cells of step (b) into neocytes and gerocytes; and (d) expressing the neocytes into a bag in direct sterile communication with the separation bag and containing a solution selected from a saline solution and a red blood cell storage solution.
Claim 19
Independent Claim
109 words
A method of preparing neocytes comprising the steps of (a) introducing a suspension of packed red blood cells and white blood cells into a filter having an entrance port and an exit port and capable of removing substantially all white blood cells from the suspension; (b) collecting the filtered red blood cells into a separation bag adapted to separate red blood cells into neocytes and gerocytes; (c) separating the cells of step (b) into neocytes and gerocytes; and (d) expressing the neocytes into a bag in direct sterile communication with the separation bag and containing a solution selected from a saline solution and a red blood cell storage solution.
Claim 20
Dependent Claim
37 words
The method of claim 16 wherein prior to step (c), the hematocrit of the non-separated red blood cells is determined and that determination is used to determine the amount of neocytes to be expressed in step (d).
Claim 21
Dependent Claim
22 words
The method of claim 16 wherein prior to introducing the suspension into the filter, an aqueous solution is passed through the filter.
Claim 22
Dependent Claim
19 words
The method of claim 18 wherein the solution is a saline solution or a red blood cell storage solution.
Claim 23
Dependent Claim
42 words
The method of claim 18 wherein the solution is contained in a bag in direct sterile communication with the filter and the separation bag and the solution is passed through the filter by introducing it into the exit port of the filter.
References Cited (Backward Citations)
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