Patent US4239081A successfully refreshed from Google Patents.
EP0397403B1
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EP
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Device and method for depletion of the leucocyte content of blood and blood components
Assignee: Pall Corp
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Filing: 1990-05-03
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Granted: 1993-12-22
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Expires: 2010-05-03
Abstract
Abstract A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from 0.5 to less than 4 mu m and a CWST of from 55 to 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is 60% to 85%.
Inventors
- 👤 David Boris Pall
- 👤 Thomas Charles Gsell
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 05:32
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3679; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
43 words
A device for the depletion of the leucocyte content of a fresh blood product which comprises a fibrous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to less than 4 f..lm and having a CWST of from 53 to 80 dynes/cm.
Claim 2
Independent Claim
43 words
A device for the depletion of the leucocyte content of a fresh blood product which comprises a fibrous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to less than 4 f..lm and having a CWST of from 53 to 80 dynes/cm.
Claim 3
Dependent Claim
47 words
A device according to claim 1 in which the fibrous leucocyte adsorption/filtration filter has a pore diameter of from 0.5 to 2 µm, a CWST of from 60 to 70 dynes/cm, and said filter has been compressed to an average voids volume of from 65% to 84%.
Claim 4
Dependent Claim
54 words
A device according to claim 2 in which the fibrous leucocyte adsorption/filtration filter has a pore diameter of from 0.5 to 2 µm, a CWST of 60 to 70 dynes/cm, and said filter is comprised of melt-blown polybutylene terephthalate fibers which have been hot compressed to an average voids volume of 65% to 84%.
Claim 5
Dependent Claim
14 words
A device according to claim 1 in which said device includes a gel prefilter.
Claim 6
Dependent Claim
77 words
device for the depletion of the leucocyte content of a fresh blood product for passing the blood product through a gel prefilter and thereafter through a fibrous leucocyte adsorption/filtration filter which comprises an adsorption/filtration filter having a pore diameter of from 0.5 to 2 µm and a CWST of 60 to 70 dynes/cm, said filter being comprised of melt-blown polybutylene terephthalate fibers which have been hot compressed to a density of 0.22 to 0.55 g/cm 3 .
Claim 7
Dependent Claim
77 words
device for the depletion of the leucocyte content of a fresh blood product for passing the blood product through a gel prefilter and thereafter through a fibrous leucocyte adsorption/filtration filter which comprises an adsorption/filtration filter having a pore diameter of from 0.5 to 2 µm and a CWST of 60 to 70 dynes/cm, said filter being comprised of melt-blown polybutylene terephthalate fibers which have been hot compressed to a density of 0.22 to 0.55 g/cm 3 .
Claim 8
Independent Claim
42 words
A device for the depletion of the leucocyte content of a fresh blood product which comprises a porous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to less than 4 µm and a CWST of from 55 to 80 dynes/cm.
Claim 9
Independent Claim
42 words
A device for the depletion of the leucocyte content of a fresh blood product which comprises a porous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to less than 4 µm and a CWST of from 55 to 80 dynes/cm.
Claim 10
Independent Claim
142 words
A method of depleting the leucocyte content of a fresh blood product by a factor of at least 100,000 which comprises passing such fresh blood product through a device comprising in sequence: a) a gel prefilter comprising a fibrous needle-punched web in which the fibers have a diameter of from 20 to 30 µm and at least about 90% of the fibers depart for at least a portion of their length from the plane of the web; b) a microaggregate filter comprising a fibrous web compressed to an average voids volume of 74% to 84%; and c) a leucocyte adsorption/filtration filter which comprises a fibrous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to 2 µm and a CWST of from 60 to 70 dynes/cm, said filter having been compressed to an average voids volume of from 65% to 84%.
Claim 11
Independent Claim
142 words
A method of depleting the leucocyte content of a fresh blood product by a factor of at least 100,000 which comprises passing such fresh blood product through a device comprising in sequence: a) a gel prefilter comprising a fibrous needle-punched web in which the fibers have a diameter of from 20 to 30 µm and at least about 90% of the fibers depart for at least a portion of their length from the plane of the web; b) a microaggregate filter comprising a fibrous web compressed to an average voids volume of 74% to 84%; and c) a leucocyte adsorption/filtration filter which comprises a fibrous leucocyte adsorption/filtration filter having a pore diameter of from 0.5 to 2 µm and a CWST of from 60 to 70 dynes/cm, said filter having been compressed to an average voids volume of from 65% to 84%.
Claim 12
Independent Claim
84 words
A method of depleting the leucocyte content of a fresh blood product by a factor of at least about 1,000 which comprises storing the fresh blood product in a first container, passing the fresh blood product from the first container through a device for the depletion of the leucocytes of a fresh blood product which comprises a porous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 4 µm and a CWST of from 55 to about 80 dynes/cm.
Claim 13
Independent Claim
84 words
A method of depleting the leucocyte content of a fresh blood product by a factor of at least about 1,000 which comprises storing the fresh blood product in a first container, passing the fresh blood product from the first container through a device for the depletion of the leucocytes of a fresh blood product which comprises a porous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 4 µm and a CWST of from 55 to about 80 dynes/cm.
Claim 14
Dependent Claim
20 words
A device according to claim 1 in which the filter has a pore diameter of from 0.5 to 2 µm.
Claim 15
Dependent Claim
18 words
A device according to claim 1 in which the filter has a CWST of 60 to 70 dynes/cm.
Claim 16
Dependent Claim
23 words
A device according to claim 1 in which the filter is hot compressed to an average voids volume of from 60% to 85%.
Claim 17
Dependent Claim
23 words
A device according to claim 11 in which the filter is hot compressed to an average voids volume of from 65% to 84%.
Claim 18
Dependent Claim
18 words
A device according to claim 1 which further comprises a microaggregate filter upstream from the leucocyte adsorption/filtration filter.
Claim 19
Dependent Claim
18 words
A device according to claim 1 which further comprises a gel prefilter upstream from the leucocyte adsorption/filtration filter.
Claim 20
Dependent Claim
24 words
A device according to claim 4 or 14 in which a microaggregate filter is interposed between the gel prefilter and the leucocyte adsorption/filtration filter.
Claim 21
Dependent Claim
23 words
A device according to claim 1 in which the leucocyte adsorption/filtration filter has a total voids volume of less than about 50 cc.
Claim 22
Dependent Claim
23 words
A device according to claim 16 in which the total voids volume of the leucocyte adsorption/filtration filter is less than about 30 cc.
Claim 23
Dependent Claim
25 words
A device according to claim 1 in which the fibers of the adsorption/filtration filter have been radiation grafted with a monomer containing a hydrophilic group.
Claim 24
Dependent Claim
20 words
A device according to claim 1 in which the filter medium is made from radiation grafted, melt-blown polybutylene terephthalate fibers.
Claim 25
Dependent Claim
52 words
A device according to claim 4 in which the gel prefilter comprises a fibrous needle-punched web in which the fibers have a diameter of from 20 to 30 µm and at least about 90% of the fibers depart for at least a portion of their length from the plane of the web.
Claim 26
Dependent Claim
31 words
A device according to claim 4 in which the gel prefilter is made from a melt-blown fibrous web wherein the fibers have an average diameter of from 10 to 30 µm.
Claim 27
Dependent Claim
53 words
A device according to claim 5 in which the gel prefilter comprises a fibrous needle-punched web in which the fibers have an average diameter of from 20 to 30 µm and at least about 90% of the fibers depart for at least a portion of their length from the plane of the web.
Claim 28
Dependent Claim
28 words
A device according to claim 5 in which the gel prefilter comprises a melt-blown fibrous web having fibers with an average diameter of from 10 to 30 µm.
Claim 29
Dependent Claim
22 words
A device according to claim 5 in which a microaggregate filter is interposed between the gel prefilter and the leucocyte adsorption/filtration filter.
Claim 30
Dependent Claim
27 words
A device according to claim 15 or 24 in which the microaggregate filter comprises a fibrous web compressed to an average voids volume of 74% to 84%.
Claim 31
Dependent Claim
28 words
A device according to claim 5 or 25 in which the fibers of the microaggregate filter have a CWST in the range or from 60 to 70 dynes/cm.
Claim 32
Independent Claim
33 words
The device according to any one of claims 1 to 26 in combination with a first container for holding the fresh blood product, the first container communicating with the fibrous leucocyte adsorption/filtration filter.
Claim 33
Dependent Claim
44 words
The device according to claim 27 in combination with a second container for holding the leucocyte-depleted fresh blood product, the second container communicating with the fibrous leucocyte adsorption/filtration filter, with the fibrous leucocyte adsorption/filtration filter interposed between the first container and the second container.
Claim 34
Dependent Claim
19 words
The device according to claim 28 in combination with third and fourth containers in communication with the first container.
Claim 35
Dependent Claim
25 words
A device according to claim 24 in which the microaggregate filter comprises a fibrous web compressed to an average voids volume of 74% to 84%.
Claim 36
Dependent Claim
26 words
A device according to claim 5 in which the fibers of the microaggregate filter have a CWST in the range of from 60 to 70 dynes/cm.
Claim 37
Dependent Claim
23 words
Adevice according to claim 1, 4, or 6 in which the filter has a CWST of from about 55 to about 80 dynes/cm.
Claim 38
Independent Claim
63 words
A method for depletion of the leucocyte content of a blood product comprising passing the blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6wm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the blood product by a factor of at least about 30,000.
Claim 39
Independent Claim
63 words
A method for depletion of the leucocyte content of a blood product comprising passing the blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6wm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the blood product by a factor of at least about 30,000.
Claim 40
Independent Claim
68 words
A method for depletion of the leucocyte content of a fresh blood product comprising passing t he fresh blood product through a fibrous leucocyte adsorption/ filtration filter having a pore diameter of from about 0.5 to less than 3.6wm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the fresh blood product by a factor of at least about 30,000.
Claim 41
Independent Claim
68 words
A method for depletion of the leucocyte content of a fresh blood product comprising passing t he fresh blood product through a fibrous leucocyte adsorption/ filtration filter having a pore diameter of from about 0.5 to less than 3.6wm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the fresh blood product by a factor of at least about 30,000.
Claim 42
Dependent Claim
29 words
The method of claim 33 or claim 34 comprising passing the blood product through a leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to about 2wm.
Claim 43
Dependent Claim
29 words
The method of claim 33 or claim 34 comprising passing the blood product through a leucocyte adsorption/ filtration filter having a CWST of about 60 to about 70 dynes/cm.
Claim 44
Dependent Claim
34 words
The method of claim 33 or claim 34 comprising passing the blood product through a leucocyte adsorption/ filtration filter having been compressed to an average voids volume of from about 60% to about 85%.
Claim 45
Dependent Claim
24 words
The method of claim 33 or claim 34 comprising passing the blood product through a leucocyte adsorption/ filtration filter having a negative zeta potential.
Claim 46
Dependent Claim
23 words
The method of claim 33 or claim 34 comprising passing the blood product through a microaggregate filter upstream of the leucocyte adsorption/filtration filter.
Claim 47
Dependent Claim
23 words
The method of claim 33 or claim 34 comprising passing the blood product through a gel prefilter upstream of the leucocyte adsorption/filtration filter.
Claim 48
Dependent Claim
25 words
The method of claim 40 comprising passing the blood product through a microaggregate filter interposed between the gel prefilter and the leucocyte adsorption/ filtration filter.
Claim 49
Dependent Claim
25 words
The method of claim 33 or claim 34 comprising passing the blood product from a container holding the blood product through the leucocyte adsorption/filtration filter.
Claim 50
Dependent Claim
27 words
The method of claim 42 further comprising passing the blood product through the leucocyte adsorption/ filtration filter into an additional container for holding the leucocyte-depleted blood product.
Claim 51
Dependent Claim
21 words
The method of claim 8 wherein the leucocyte-depleted fresh blood product after passing through the device passes into a second container.
Claim 52
Dependent Claim
14 words
The method of claim 8 wherein the fresh blood product is packed red cells.
Claim 53
Independent Claim
21 words
A device according to any one of claims 1,5 and 6 wherein the leucocyte adsorption/filtration filter has a negative zeta potential.
References Cited (Backward Citations)
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