EP0394050A2
Expired / Lapsed
EP
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A method of preparing a freeze-dried formulation containing a drug
Assignee: Sankyo Co Ltd
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Filing: 1990-04-18
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Granted: —
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Expires: 2010-04-18
Abstract
Abstract In a freeze-drying method for producing a dried pharmaceutical compound or preparation, a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains said pharmaceutical compound or preparation dissolved or suspended therein. The other liquid or liquids may be pure solvent (generally water) or may contain one or more other substances.
Inventors
- 👤 Seigo C/O Sankyo Company Limited Ueda
- 👤 Takashi C/O Sankyo Company Limited Shiokari
- 👤 Kunio C/O Sankyo Company Limited Hashi
- 👤 Akira C/O Sankyo Company Limited Kusai
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 23:44
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; F; F26; F26B; F26B5/00; F26B5/04; F26B5/06; A23; A23B; A23B2/00; A23B2/90; A23B2/92; A61K9/19
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
59 words
A method of preparing a freeze-dried preparation in which a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 2
Independent Claim
59 words
A method of preparing a freeze-dried preparation in which a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 3
Dependent Claim
16 words
A method according to Claim 1, in which each of said liquids is an aqueous liquid.
Claim 4
Dependent Claim
31 words
A method according to Claim 2, in which one of said first and said second liquids is water and the other is an aqueous solution of said pharmaceutical compound or preparation.
Claim 5
Dependent Claim
25 words
A method according to Claim 2, in which each of said first and said second liquids is an aqueous solution of a physiologically active substance.
Claim 6
Dependent Claim
35 words
A method according to Claim 1, in which a third liquid is added to the frozen first and second liquids and is frozen thereon, and the frozen first, second and third liquids are freeze-dried together.
Claim 7
Dependent Claim
20 words
A method according to Claim 5, in which each of said first, second and third liquids is an aqueous liquid.
Claim 8
Dependent Claim
29 words
A method according to Claim 6, in which one of said first, second and third liquids is water and the others are aqueous solutions of pharmaceutical compounds or preparations.
Claim 9
Dependent Claim
25 words
A method according to Claim 6, in which each of said first, second and third liquids is an aqueous solution of a physiologically active substance.
Claim 10
Independent Claim
25 words
A method according to any one of the preceding Claims, in which said first liquid is frozen to a temperature of from -10°C to -50°C.
Claim 11
Dependent Claim
15 words
A method according to Claim 9, in which said temperature is from -30°C to -50°C.
Claim 12
Dependent Claim
13 words
A method according to Claim 10, in which said temperature is about -40°C.
Claim 13
Independent Claim
24 words
A method according to any one of the preceding Claims, in which the total thickness of all frozen layers does not exceed 40 mm.
Claim 14
Dependent Claim
17 words
A method according to Claim 12, in which each layer is of thickness at least 1 mm.
Claim 15
Dependent Claim
17 words
A method according to Claim 13, in which each layer is of thickness at least 2 mm.
Claim 16
Independent Claim
18 words
A method according to any one of the preceding Claims, in which said pharmaceutical compound is a drug.
Claim 17
Independent Claim
19 words
A method according to any one of Claims 1 to 14, in which said pharmaceutical compound is a vitamin.
Claim 18
Independent Claim
75 words
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10°C to -50°C, a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 19
Independent Claim
75 words
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10°C to -50°C, a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 20
Independent Claim
110 words
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10°C to -50°C, a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon to a temperature of from -10°C to -50°C, a third aqueous liquid is added to the frozen first and second liquids without melting the frozen first and second liquids and is frozen thereon, and the frozen first, second and third liquids are freeze-dried together, in which at least one of said first, second and third liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 21
Independent Claim
110 words
A method of preparing a freeze-dried preparation in which a first aqueous liquid is frozen to a temperature of from -10°C to -50°C, a second aqueous liquid is added to the frozen first liquid without melting the frozen first liquid and is frozen thereon to a temperature of from -10°C to -50°C, a third aqueous liquid is added to the frozen first and second liquids without melting the frozen first and second liquids and is frozen thereon, and the frozen first, second and third liquids are freeze-dried together, in which at least one of said first, second and third liquids contains a pharmaceutical compound or preparation dissolved or suspended therein.
Claim 22
Independent Claim
18 words
A method according to any one of the preceding Claims, in which freeze-drying takes place in a vial.
Claim 23
Dependent Claim
28 words
A freeze-dried product prepared by a process according to any one of the preceding Claims, which has been freeze-dried in a vial and is provided in that vial.
References Cited (Backward Citations)
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