EP0386960A2
Expired / Lapsed
EP
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Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
Assignee: Wyeth Holdings LLC
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Filing: 1990-03-02
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Granted: —
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Expires: 2010-03-02
Abstract
Abstract There is provided a pharmaceutical composition which comprises an aqueous vehicle, a compound having reversible thermosetting gel properties and a compound having film-forming properties. Depending on the relative proportions of these components, the composition can be adapted to function either as a vehicle for delivering pharmacologically or diagnostically active compounds to a human or animal patient and/or as a wound dressing composition.
Inventors
- 👤 Mark Gibson
- 👤 Peter Mark Taylor
- 👤 Nicholas Ian Payne
- 👤 Philip Leon Gould
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 13:07
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0071; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0031; A61K9/0034; A61K9/0048; A61K9/0053; A61K9/006; A61K9/70; A61K9/7015; A61L2/00; A61L2/02; A61L2/08; A61L26/0009; A61L26/0052; A61L26/0066; A61L26/008; A61L2300/00; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
60 words
A drug delivery composition, comprising an aqueous vehicle containing (a) from 1% to 30% by weight of one or more compounds having reversible thermosetting gel properties, and (b) from 1% to 15% by weight of one or more compounds, compatible with component (a), having film-forming properties, and the composition having a sol-gel transition temperature within the range 0° to 50°C.
Claim 2
Dependent Claim
60 words
A drug delivery composition, comprising an aqueous vehicle containing (a) from 1% to 30% by weight of one or more compounds having reversible thermosetting gel properties, and (b) from 1% to 15% by weight of one or more compounds, compatible with component (a), having film-forming properties, and the composition having a sol-gel transition temperature within the range 0° to 50°C.
Claim 3
Dependent Claim
25 words
A composition according to Claim 1 and comprising also from 0.001% to 35% by weight of at least one compound having pharmacological or diagnostic activity.
Claim 4
Dependent Claim
21 words
A composition according to Claim 1 or Claim 2 and having a sol-gel transition temperature within the range 10° to 40°C.
Claim 5
Dependent Claim
16 words
A composition according to Claim 3 and having a sol-gel transition temperature within the range 15°-35°C.
Claim 6
Dependent Claim
24 words
A composition according to Claim 3, for application topically to the body tissues of a patient, and having a sol-gel transition temperature of 15°-20°C.
Claim 7
Dependent Claim
17 words
A composition according to Claim 3, for application ophthalmically, and having a sol-gel transition temperature of 20°-26°C.
Claim 8
Dependent Claim
28 words
A composition according to any preceding claim, and having a viscosity of 0.5 to 250 poise (Brookfield Model LV, No. 4 spindle) immediately below its sol-gel transition temperature.
Claim 9
Dependent Claim
49 words
A composition according to any preceding claim, comprising (a) from 3% to 30% by weight of said one or more compounds having reversible thermosetting gel-properties, and (b) from 3% to 15% by weight of said one or more compounds having film-forming properties, said composition on setting forming a gel.
Claim 10
Dependent Claim
28 words
A composition according to Claim 8, comprising from 5% to 15% by weight of said component (a) and from 5% to 10% by weight of said component (b).
Claim 11
Dependent Claim
51 words
A composition according to any one of Claims 1-7, comprising (a) from 1% to 10% by weight of said one or more compounds having reversible thermosetting gel-properties, and (b) from 1% to 10% by weight of said one or more compounds having film-forming properties, said composition on setting forming a gel.
Claim 12
Dependent Claim
28 words
A composition according to Claim 10, comprising from 4% to 7% by weight of said component (a) and from 4% to 7% by weight of said component (b).
Claim 13
Dependent Claim
52 words
A composition according to any one of Claims 1-7, comprising (a) from 1% to 5% by weight of said one or more compounds having reversible thermosetting gel properties, and (b) from 5% to 15% by weight of said one or more compounds having film-forming properties, said composition on setting forming a gel.
Claim 14
Dependent Claim
26 words
A composition according to Claim 12, comprising from 2% to 3% by weight of said component (a) and from 8% to 12% of said component (b).
Claim 15
Dependent Claim
36 words
A composition according to any preceding claim, wherein said component (a) comprises one or more compounds selected from block copolymers of polyoxyethylene-polyoxypropylene and tetra-substituted derivatives of ethylene diamine where the substituents are block copolymers of polyoxyethylene-polyoxypropylene.
Claim 16
Dependent Claim
23 words
A composition according to Claim 14, wherein said component (a) comprises a polyoxyethylene-polyoxypropylene block copolymer having an average molecular weight of about 11,500.
Claim 17
Dependent Claim
23 words
A composition according to any preceding claim, wherein said component (b) comprises one or more compounds selected from hydroxyethylcellulose, hydroxypropylmethylcellulose and polyvinyl alcohol.
Claim 18
Dependent Claim
16 words
A composition according to Claim 16, wherein said component (b) is a low viscosity grade hydroxyethylcellulose.
Claim 19
Dependent Claim
13 words
A composition according to any preceding claim, wherein said aqueous vehicle is water.
Claim 20
Dependent Claim
21 words
A composition according to any preceding claim, comprising also a hydroxy- or polyhydroxy-compound to improve the physical stability of the composition.
Claim 21
Dependent Claim
22 words
A composition according to Claim 19, wherein said stability-improving compound is selected from benzyl alcohol, glycerol, propylene glycol, ethanolamine, mannitol and sorbitol.
Claim 22
Dependent Claim
18 words
A composition according to Claim 20, wherein said composition comprises from 0.5% to 20% by weight of sorbitol.
Claim 23
Dependent Claim
11 words
A composition according to any preceding claim which has been sterilized.
Claim 24
Dependent Claim
125 words
A wound dressing composition comprising an aqueous vehicle containing (a) from 1% to 30% by weight of the composition of one or more compounds having reversible thermosetting gel properties, and (b) from 1% to 20% by weight of the composition of one or more compounds, compatible with component (a) having film-forming properties, and the composition having a sol-gel transition temperature within the range 10° to 30°C, a viscosity of not greater than 250 poise, as determined by a Brookfield viscometer (Model LV with No. 4 spindle), at a temperature immediately below its sol-gel transition temperature whereby the mixture is pourable onto a wound to be treated when below said transition temperature, and in contact with the skin setting to form a non-flowable gelatinous wound dressing.
Claim 25
Dependent Claim
125 words
A wound dressing composition comprising an aqueous vehicle containing (a) from 1% to 30% by weight of the composition of one or more compounds having reversible thermosetting gel properties, and (b) from 1% to 20% by weight of the composition of one or more compounds, compatible with component (a) having film-forming properties, and the composition having a sol-gel transition temperature within the range 10° to 30°C, a viscosity of not greater than 250 poise, as determined by a Brookfield viscometer (Model LV with No. 4 spindle), at a temperature immediately below its sol-gel transition temperature whereby the mixture is pourable onto a wound to be treated when below said transition temperature, and in contact with the skin setting to form a non-flowable gelatinous wound dressing.
Claim 26
Dependent Claim
18 words
A wound dressing composition according to Claim 23, having a sol-gel transition temperature of from 10° to 25°C.
Claim 27
Dependent Claim
18 words
A wound dressing composition according to Claim 24, having a sol-gel transition temperature of from 15° to 20°C.
Claim 28
Dependent Claim
37 words
A wound dressing composition according to any one of Claims 23-25, having a viscosity of 50 to 250 poise, as determined by a Brookfield viscometer (Model LV with No. 4 spindle) immediately below its sol-gel transition temperature.
Claim 29
Dependent Claim
27 words
A wound dressing composition according to any one of Claims 23-26, wherein the gel-forming component exhibits reversible thermosetting gel properties at a temperature within the range 10°-45°C.
Claim 30
Dependent Claim
54 words
A wound dressing composition according to any one of Claims 23-27, comprising 1% to 5% by weight of the composition of the gel-forming component (a) and from 5% to 20% by weight of the composition of the film-forming component (b), the composition setting in contact with the skin to form a coherent film thereon.
Claim 31
Dependent Claim
13 words
A wound dressing composition according to Claim 27 and including also a plasticizer.
Claim 32
Dependent Claim
50 words
A wound dressing composition according to Claim 29, comprising from 2% to 3% by weight of the composition of the gel-forming component (a), from 8% to 12% by weight of the composition of the film-forming component (b) and from 1% to 10% by weight of the composition of the plasticizer.
Claim 33
Dependent Claim
17 words
A wound dressing composition according to Claim 29 or Claim 30, wherein the plasticizer is polyethylene glycol.
Claim 34
Dependent Claim
54 words
A wound dressing composition according to any one of Claims 23-27, comprising from 5% to 30% by weight of the composition of the gel-forming component (a) and from 1% to 15% by weight of the composition of the film-forming component (b), the composition setting in contact with the skin to form a rigid gel.
Claim 35
Dependent Claim
38 words
A wound dressing composition according to Claim 32, comprising from 7% to 20% by weight of the composition of the gel-forming component (a) and from 7% to 12% by weight of the composition of the film-forming component (b).
Claim 36
Dependent Claim
21 words
A wound dressing composition according to Claim 32 or Claim 33, comprising also an hydroxy- or polyhydroxy-compound as a stabilizing agent.
Claim 37
Dependent Claim
14 words
A wound dressing composition according to Claim 34, wherein the stabilizing agent is sorbitol.
Claim 38
Dependent Claim
30 words
A wound dressing composition according to Claim 34 or Claim 35, wherein the stabilizing agent is present in an amount of from 1% to 10% by weight of the composition.
Claim 39
Dependent Claim
16 words
A wound dressing composition according to any one of Claims 23-36 and including also a preservative.
Claim 40
Dependent Claim
20 words
A wound dressing composition according to any one of Claims 23-27, having a pH in the range 4 to 7.5.
Claim 41
Dependent Claim
17 words
A wound dressing composition according to Claim 38, having a pH in the range 4.5 to 6.5.
Claim 42
Dependent Claim
22 words
A wound dressing composition according to any one of Claims 23-39 and including also one or more biologically and/or pharmaceutically active components.
Claim 43
Dependent Claim
12 words
A sterile wound dressing composition according to any one of Claims 23-40.
Claim 44
Dependent Claim
18 words
A sterile wound dressing composition according to Claim 41 in a container for dispensing onto a wound site.
References Cited (Backward Citations)
No citation records indexed.
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