§
Luxuse
Patent Intelligence
Sign In
← Back to Patent Explorer
EP0375976A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Compounds binding to a heparin receptor as inhibitors of T cell-mediated immune reactions

Assignee: Hadassah Medical Organization
•
Filing: 1989-11-30
•
Granted: —
•
Expires: 2009-11-30
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract There are provided compositions for the inhibition of T-Cell-­mediated immune reactions, which comprise an effective quantity of Fragmin (T.M.) of polyanethol sulfonate, of dextran sulfate or of another compound which binds to the heparin receptor. The compositions of the invention are effective as active ingredient of pharmaceutical compositions for the treatment of patients afflicted with metastatic tumor cells. Another feature of the invention is an assay for the determination of inhibitory effects of such compositions on T-cell immunity in vivo by their ability to compete with heparin for binding in the heparin receptor.

Inventors

  • 👤 Irun R. Cohen
  • 👤 Theodore D. Miller
  • 👤 Yaacov Naparstek

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-28 17:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/74; A61K31/795; A61P; A61P37/00; A61P37/02; A61P37/06

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 22 words
A composition for the inhibition of T cell-mediated immune reactions, comprising an effective quantity of a com­pound binding to the heparin receptor.
Claim 2
Dependent Claim 22 words
A composition for the inhibition of T cell-mediated immune reactions, comprising an effective quantity of a com­pound binding to the heparin receptor.
Claim 3
Dependent Claim 11 words
A composition according to claim 1, wherein said compound is Fragmin.
Claim 4
Dependent Claim 12 words
A composition according to claim 1, wherein said compound is dextran sulfate.
Claim 5
Dependent Claim 12 words
A composition according to claim 1, wherein said compound is polyanethol sulfonate.
Claim 6
Dependent Claim 25 words
A composition according to claim 1, wherein said compound binds to the heparin receptor in competition with heparin and has a similar effect to heparin.
Claim 7
Dependent Claim 16 words
A composition according to any one of claims 1 to 5, which is a pharmaceutical composition.
Claim 8
Dependent Claim 16 words
A composition according to claim 6 for the treatment of patients afflicted with metastatic tumor cells.
Claim 9
Dependent Claim 39 words
A composition according to any one of claims 1 to 5, which is a diagnostic composition for the determination of heparin-like effects on immmunity or heparanase by measuring the binding of said compound contained therein to the heparin receptor.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Maintenance schedule is calculated for granted US utility patents.

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag