EP0361485A2
Expired / Lapsed
EP
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A method of sensitizing multidrug resistant cells to antitumor agents
Assignee: Yale University
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Filing: 1989-09-28
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Granted: —
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Expires: 2009-09-28
Abstract
Abstract A method for sensitizing multidrug resistant cells to antitumor agents comprising contacting multidrug resistant cells, with an effective amount of a compound of the formula wherein n is 1, 2 or 3, X is CF₃, -O-CH₃, Br, I, Cl, H, W and S-CH₃ and R¹ and R², independently of each other are -CH₃-CH₂-CH₃, CH₂CH₂OHCH₂OH, or NR¹ R² form a ring wherein R³ is -CH₃, CH₂-CH₃,-H, CH₂OH and CH₂CH₂OH.
Inventors
- 👤 William N. Hait
- 👤 James M. Ford
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 14:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K31/495; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
68 words
A method for sensitizing multidrug resistant cells to antitumor agents comprising contacting said multidrug resistant cells with an effective amount of a compound of a formula wherein n is 1, 2, 3 or 4, X is selected from the group consisting of -CF₃, -Cl, -Br, -I, -OCF₃, -H, CN and S-CH₃, and R¹ and R², independently of one another, are -CH₂, -CH₃, -CH₂OH, -CH₃, H, OH and CH₂CH₂OH.
Claim 2
Independent Claim
68 words
A method for sensitizing multidrug resistant cells to antitumor agents comprising contacting said multidrug resistant cells with an effective amount of a compound of a formula wherein n is 1, 2, 3 or 4, X is selected from the group consisting of -CF₃, -Cl, -Br, -I, -OCF₃, -H, CN and S-CH₃, and R¹ and R², independently of one another, are -CH₂, -CH₃, -CH₂OH, -CH₃, H, OH and CH₂CH₂OH.
Claim 3
Dependent Claim
10 words
A method according to claim 1, wherein X is CF₃.
Claim 4
Dependent Claim
10 words
A method according to claim 1, wherein n is 3.
Claim 5
Dependent Claim
46 words
A method according to claim 1, wherein R¹ and R² together with the nitrogen atom they are bound to, form a six membered heterocyclic ring, said ring being of the formula ,wherein R³ is selected from the group consisting of -CH₃, -CH₂CH₂OH, -CH₂CH₃, -H and CH₂OH.
Claim 6
Dependent Claim
10 words
A method according to claim 4, wherein R³ is -CH₃.
Claim 7
Dependent Claim
16 words
A method according to claim 1, wherein the compound is wherein A is CH₃ or CH₂CH₂OH.
References Cited (Backward Citations)
No citation records indexed.
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