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EP0358948A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Method for automatically processing magnetic solid phase reagents

Assignee: EIDP Inc
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Filing: 1989-08-09
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Granted: —
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Expires: 2009-08-09
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Abstract

Abstract Magnetic particles used as a solid support are placed in reaction vessels and stepped sequentially past successive magnets for separation.

Inventors

  • 👤 Ching-Cherng Lee
  • 👤 James E. Davis

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-05 04:12
CPC Classifications
B; B03; B03C; B03C1/00; G; G01; G01N; G01N35/00; G01N35/02; G01N35/021; B03C1/005; B03C1/01; B03C1/02; B03C1/28; B03C1/288; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; B03C2201/00; B03C2201/26; G01N35/0098; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/111666; Y10T436/113332; Y10T436/25; Y10T436/25375

Claims Analysis

Total Claims: 22
Claim 1
Independent Claim 68 words
An automatic apparatus for separating particles from aqueous dispersions of such particles disposed in a plurality of reaction vessels, the particles being responsive to a magnetic field comprising: a transport means for moving the vessels in sequence past a plurality of sequentially located processing positions, and a first frame having a plurality of magnets, each located adjacent a different one of a selected number of the processing positions.
Claim 2
Dependent Claim 68 words
An automatic apparatus for separating particles from aqueous dispersions of such particles disposed in a plurality of reaction vessels, the particles being responsive to a magnetic field comprising: a transport means for moving the vessels in sequence past a plurality of sequentially located processing positions, and a first frame having a plurality of magnets, each located adjacent a different one of a selected number of the processing positions.
Claim 3
Dependent Claim 23 words
The apparatus set forth in claim 1 wherein the transport means indexes the vessels stepwise to the processing positions which are consecutively located.
Claim 4
Dependent Claim 48 words
The automatic apparatus set forth in claim 2 wherein the reaction vessels each have a longitudinal axis that is generally vertically disposed while the vessels are being indexed, and at least two consecutively positioned magnets being positioned at different heights relative to the longitudinal axis of the vessels.
Claim 5
Dependent Claim 22 words
The apparatus of claim 3 wherein the consecutively positioned magnets have alternate south and north poles adjacent the sequentially located processing positions.
Claim 6
Dependent Claim 43 words
The apparatus of claim 4 which includes an element having a low magnetic reluctance positioned adjacent the poles of two consecutively positioned magnets the element being remote from the processing positions, thereby providing a magnetic flux return path for the consecutively positioned magnets.
Claim 7
Dependent Claim 30 words
The apparatus of claim 5 where the magnet adjacent the last processing position of the frame has a magnetic flux that is greater than the flux of the remaining magnets.
Claim 8
Dependent Claim 30 words
The apparatus of claim 2 where the magnet adjacent the last processing position of the frame provides a magnetic flux that is greater than the flux of the remaining magnets.
Claim 9
Dependent Claim 30 words
The apparatus of claim 4 where the magnet adjacent the last processing position of the frame provides a magnetic flux that is greater than the flux of the remaining magnets.
Claim 10
Dependent Claim 22 words
The apparatus of claim 2 wherein the consecutively positioned magnets have alternate south and north poles adjacent the sequentially located processing positions.
Claim 11
Dependent Claim 30 words
The apparatus of claim 9 where the magnet adjacent the last processing position of the frame provides a magnetic flux that is greater than the flux of the remaining magnets.
Claim 12
Dependent Claim 70 words
The apparatus of claim 2 wherein the reaction vessels each have a longitudinal axis that is generally vertically disposed while the vessels are being indexed, and which includes a second frame having a second plurality of magnets, each located adjacent a different one of the selected number of processing positions, said second frame being spaced from the first frame to provide a slot for the passage of the reaction vessels.
Claim 13
Dependent Claim 62 words
An automatic method for separating particles from aqueous dispersions of such particles disposed in a plurality of reaction vessels, the particles being responsive to the magnetic field comprising the steps of: transporting the vessels to a plurality of processing positions, and subjecting the vessels and hence the particles in each vessel at at least two consecutive processing positions to a magnetic field.
Claim 14
Dependent Claim 62 words
An automatic method for separating particles from aqueous dispersions of such particles disposed in a plurality of reaction vessels, the particles being responsive to the magnetic field comprising the steps of: transporting the vessels to a plurality of processing positions, and subjecting the vessels and hence the particles in each vessel at at least two consecutive processing positions to a magnetic field.
Claim 15
Dependent Claim 45 words
The method of claim 12 wherein the vessels have a longitudinal axis and includes the steps of: orienting the vessels longitudinal axes vertically while subjected to the magnetic field, and applying the magnetic field to different heights, relative to the longitudinal axis of the vessel.
Claim 16
Dependent Claim 19 words
The method of claim 13 wherein the magnetic field is applied in opposite senses at the consecutive processing positions.
Claim 17
Dependent Claim 31 words
The method of claim 14 which includes the steps of subjecting the vessels at the last of the selected processing positions to a stronger magnetic field than at the remaining positions.
Claim 18
Dependent Claim 20 words
The method of claim 12 wherein the magnetic field is applied in opposite senses at the selected consecutive processing positions.
Claim 19
Dependent Claim 20 words
The method of claim 12 wherein the transporting means transports the vessels in a stepwise manner to each processing position.
Claim 20
Dependent Claim 52 words
The method of claim 17 wherein the vessels have a longitudinal axis and includes the steps of: orienting the vessels longitudinal axes vertically while subjected to the magnetic field, and applying the magnetic field to different heights, at at least two consecutive processing positions, relative to the longitudinal axis of the vessel.
Claim 21
Dependent Claim 20 words
The method of claim 18 wherein the magnetic field is applied in opposite senses at the selected consecutive processing positions.
Claim 22
Dependent Claim 20 words
The method of claim 17 wherein the magnetic field is applied in opposite senses at the selected consecutive processing positions.

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