EP0353589A2
Expired / Lapsed
EP
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Apparatus and method for providing assay calibration data
Assignee: Abbott Laboratories
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Filing: 1989-07-24
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Granted: —
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Expires: 2009-07-24
Abstract
Abstract A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel (18) is provided to position and hold a plurality of reaction cartridges (80). Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well (86) which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader (32) operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
Inventors
- 👤 Joseph Patrick Donohue
- 👤 Christopher Nicholas Mattimiro
- 👤 Mark Wallace Bailey
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 03:15
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N35/00; G01N35/10; G01N35/1009; B; B01; B01L; B01L3/00; B01L3/54; B01L3/545; G01N33/80; G01N35/00584; G01N35/00594; G01N35/00712; G01N35/00722; G01N35/00732; G01N21/00; G01N21/17; G01N21/47; G01N21/4738; G01N2021/4776; G01N2021/478; G01N2035/00742; G01N2035/00752; G01N2035/00762; G01N2035/1025; G01N35/1081; G01N35/1083; G01N2035/1086; G01N21/84; G01N21/8483; G01N2201/00; G01N2201/12; G01N2201/127; G01N2201/12746; G01N2201/12753
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
139 words
Apparatus for providing assay calibration data for assaying a biological sample, comprising: means containing predetermined assay calibration data for normalizing the results of at least one assay with respect to at least one predetermined standard value, said calibration data including first code means for identifying at least one assay to which said calibration data corresponds; storage means for storing said calibration data; means for entering said calibration data from said means containing said calibration data to a location in said storage means; means adapted for use in carrying out at least one assay, said means containing second code means corresponding to the said at least one assay to be carried out; and means responsive to said second code means for correlating said second code means to said first code means to access the calibration data in said storage means.
Claim 2
Dependent Claim
139 words
Apparatus for providing assay calibration data for assaying a biological sample, comprising: means containing predetermined assay calibration data for normalizing the results of at least one assay with respect to at least one predetermined standard value, said calibration data including first code means for identifying at least one assay to which said calibration data corresponds; storage means for storing said calibration data; means for entering said calibration data from said means containing said calibration data to a location in said storage means; means adapted for use in carrying out at least one assay, said means containing second code means corresponding to the said at least one assay to be carried out; and means responsive to said second code means for correlating said second code means to said first code means to access the calibration data in said storage means.
Claim 3
Dependent Claim
36 words
The apparatus defined in claim 1 wherein: said means containing said calibration data includes means containing machine-readable calibration data; and said means for entering said calibration data includes reader means for reading said machine-readable calibration data.
Claim 4
Dependent Claim
55 words
The apparatus defined in claim 1 wherein said means containing said calibration data comprises means containing calibration data for normalizing each of a preselected panel of assays each with respect to at least one predetermined standard value, and wherein said first code means identifies said preselected panel of assays to which said calibration data corresponds.
Claim 5
Dependent Claim
40 words
The apparatus defined in claim 1 wherein said means adapted for use in carrying out at least one assay comprises disposable reaction cartridge means having bound thereto at least one preselected binding component for the assay to be carried out.
Claim 6
Dependent Claim
52 words
The apparatus defined in claim 1 wherein: said means adapted for use in carrying out at least one assay and containing second code means includes means containing machine readable second code means; and said means responsive to said second code means includes reader means for reading said machine readable second code means.
Claim 7
Independent Claim
136 words
A method for providing assay calibration data for use by an instrument which is operative to assay a biological sample, comprising the steps of: providing predetermined assay calibration data adapted for use in normalizing the results of at least one assay with respect to at least one predetermined standard value, said calibration data including first code means for identifying at least one assay to which said calibration data corresponds; entering said calibration data into a location in a data storage means; providing means adapted for use by a said instrument in carrying out at least one assay, said means containing second code means corresponding to the said at least one assay to be carried out; and using said second code means to access the calibration data having corresponding first code means in said data storage means.
Claim 8
Independent Claim
136 words
A method for providing assay calibration data for use by an instrument which is operative to assay a biological sample, comprising the steps of: providing predetermined assay calibration data adapted for use in normalizing the results of at least one assay with respect to at least one predetermined standard value, said calibration data including first code means for identifying at least one assay to which said calibration data corresponds; entering said calibration data into a location in a data storage means; providing means adapted for use by a said instrument in carrying out at least one assay, said means containing second code means corresponding to the said at least one assay to be carried out; and using said second code means to access the calibration data having corresponding first code means in said data storage means.
Claim 9
Dependent Claim
50 words
The method defined in claim 6 wherein: the step of providing calibration data includes providing means containing machine readable calibration data; and the step of entering said calibration data into a data storage means includes providing reader means for readings said machine-readable calibration data from said means containing said data.
Claim 10
Dependent Claim
67 words
The method defined in claim 6 wherein the step of providing calibration data includes providing calibration data adapted for use by a said instrument in normalizing the result of each assay of a preselected panel of assays with respect to at least one corresponding predetermined standard value, the calibration data including first code means which identifies the preselected panel of assays to which said calibration data corresponds.
Claim 11
Dependent Claim
48 words
The method defined in claim 6 wherein the step of providing means adapted for use by a said instrument in carrying out at least one assay includes providing disposable reaction cartridge means having bound thereto at least one preselected binding component for the assay to be carried out.
Claim 12
Dependent Claim
55 words
The method defined in claim 6 wherein the step of providing means adapted for use by a said instrument in carrying out at least one assay includes providing disposable reaction cartridge means having bound thereto in spaced relationship a plurality of preselected assay binding components for a preselected panel of assays to be carried out.
References Cited (Backward Citations)
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