EP0345628A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Solid pharmaceutical dosage in tablet triturate form and method of producing same
Assignee: Abbott Laboratories
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Filing: 1989-06-01
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Granted: —
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Expires: 2009-06-01
Abstract
Abstract A solid pharmaceutical dosage in tablet triturate form is disclosed. The tablet triturate form includes a cementatory network constituted by a water-soluble but ethanol-insoluble carbohydrate. Also included are discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, an emulsifier, and sodium bicarbonate wherein the discrete particles have a triglyceride coating.
Inventors
- 👤 Kurt Gard Van Scoik
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 15:29
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/20; A61K9/2072; A61K9/2077
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
73 words
A solid pharmaceutical dosage in tablet triturate form, suitable for oral administration, and comprising a porous cementatory network constituted by a water-soluble but ethanol-insoluble carbohydrate; and discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, having a triglyceride coating, substantially uniformly distributed throughout said network, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof; said triglyceride coating constituting a major portion of the weight of each said discrete particle.
Claim 2
Dependent Claim
73 words
A solid pharmaceutical dosage in tablet triturate form, suitable for oral administration, and comprising a porous cementatory network constituted by a water-soluble but ethanol-insoluble carbohydrate; and discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, having a triglyceride coating, substantially uniformly distributed throughout said network, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof; said triglyceride coating constituting a major portion of the weight of each said discrete particle.
Claim 3
Dependent Claim
14 words
The dosage form in accordance with claim 1 wherein the active ingredient is estazolam.
Claim 4
Dependent Claim
19 words
The dosage form in accordance with Claim 2 wherein the discrete particles further include an emulsifier and a polymer.
Claim 5
Dependent Claim
16 words
The dosage form in accordance with Claim 3 wherein the discrete particles further include sodium bicarbonate.
Claim 6
Dependent Claim
81 words
A solid pharmaceutical dosage in tablet triturate form, suitable for oral administration, and comprising a porous cementatory network constituted by a water-soluble but ethanol insoluble carbohydrate; and discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, sodium bicarbonate, and an emulsifier having a triglyceride coating, substantially uniformly distributed throughout said network, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof; said triglyceride coating constituting a major portion of the weight of each said discrete particle.
Claim 7
Dependent Claim
81 words
A solid pharmaceutical dosage in tablet triturate form, suitable for oral administration, and comprising a porous cementatory network constituted by a water-soluble but ethanol insoluble carbohydrate; and discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, sodium bicarbonate, and an emulsifier having a triglyceride coating, substantially uniformly distributed throughout said network, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof; said triglyceride coating constituting a major portion of the weight of each said discrete particle.
Claim 8
Dependent Claim
29 words
The dosage form in accordance with claim 1 wherein the cementatory network is constituted by lactose and said discrete particles are constituted by estazolam enveloped in hydrogenated cottonseed oil.
Claim 9
Dependent Claim
48 words
The dosage form in accordance with claim 1 wherein the carbohydrate is lactose, the active ingredient is estazolam, the triglyceride is hydrogenated cottonseed oil, the polymer is PEG 300, and the emulsifier is licithin, wherein the carbohydrate is about 94 percent of the total weight of the tablet.
Claim 10
Independent Claim
106 words
A method of manufacturing a solid pharmaceutical dosage in tablet triturate form, suitable for oral administration which comprises: admixing a particulate water-soluble but ethanol-insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient enveloped in a triglyceride coating, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof and constituting a major portion of the weight of each said discrete particle; combining the resulting admixture with a volatilizable liquid binder in which said carbohydrate has limited solubility in an amount sufficient to form a moldable mass; shaping said moldable mass into tablets; and drying said shaped tablets to a rigid structure.
Claim 11
Independent Claim
106 words
A method of manufacturing a solid pharmaceutical dosage in tablet triturate form, suitable for oral administration which comprises: admixing a particulate water-soluble but ethanol-insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient enveloped in a triglyceride coating, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof and constituting a major portion of the weight of each said discrete particle; combining the resulting admixture with a volatilizable liquid binder in which said carbohydrate has limited solubility in an amount sufficient to form a moldable mass; shaping said moldable mass into tablets; and drying said shaped tablets to a rigid structure.
Claim 12
Independent Claim
79 words
A method of manufacturing a solid pharmaceutical dosage in tablet triturate form, suitable for oral administration which comprises: admixing a particulate water-soluble but ethanol insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, an emulsifier, and sodium bicarbonate enveloped in a triglyceride coating, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof and constituting a major portion of the weight of each said discrete particle; and, tabletting the produced admixture.
Claim 13
Independent Claim
79 words
A method of manufacturing a solid pharmaceutical dosage in tablet triturate form, suitable for oral administration which comprises: admixing a particulate water-soluble but ethanol insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, an emulsifier, and sodium bicarbonate enveloped in a triglyceride coating, said triglyceride coating being insoluble in water, ethanol, saliva or combinations thereof and constituting a major portion of the weight of each said discrete particle; and, tabletting the produced admixture.
Claim 14
Dependent Claim
37 words
In a method of manufacturing a tablet triturate dosage form, the improvement which comprises: admixing a particulate water-soluble but ethanol-insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient enveloped in a triglyceride coating.
Claim 15
Dependent Claim
37 words
In a method of manufacturing a tablet triturate dosage form, the improvement which comprises: admixing a particulate water-soluble but ethanol-insoluble carbohydrate with discrete particles containing a solid, water-soluble but triglyceride-insoluble active ingredient enveloped in a triglyceride coating.
References Cited (Backward Citations)
No citation records indexed.
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