Use of pyroglutamic acid alkyl esters for the manufacture of a medicament for the treatment of ichthyosis

Claim 1

The use of a curative agent chosen from esters of pyroglutamic acid and mixtures thereof, in the preparation of a therapeutic composition for the treatment of the skin disorders: Ichthyosiform dermatoses, notably: Ichthyosis vulgaris, Sex-linked ichthyosis, Lamellar ichthyosis, Epidermolytic ichthyosis, Conradi's syndrome Localised hyperkeratotic conditions, notably: Keratosis pilaris, Keratosis punctata, Keratosis senilis, Keratosis striata, Dandruff Callous-forming disorders, notably: Palmar and Plantar hyperkeratosis, including corns, Palmar and Plantar keratoderma, Psoriasis, Eczema, Xerosis, Warts, notably: Keratotic warts, Herpes, Keratoacanthoma, Warty naevus, Tinea pedis and other dermatomycoses, Pityriasis rosea & Pityriasis alba, Lichen planus & Lichen simplex chronicus, Cicatricial alopecia with dry flaky scalp, Darier's disease, Pruritus, Seborrhoeic dermatitis, Seborrhoeic eczema, Acne, Scabies, Alopecia; the esters of pyroglutamic acid having the structure: where R is a linear or branched chain, saturated or unsaturated alkyl group having from 1 to 30 carbon atoms, or the group: - - -OR˝ where R′ and R˝ are the same or different and are each represented by H or the group: [(CH₃) u ,(CH₂OH) v ,(CH₂) w ,(CHCH₃) x ,(CHOH) y ,(CH=CH) z ] -      (2) where u is zero, or 1 v is zero, or 1 w is zero, or an integer of from 1 to 21 x is zero, or an integer of from 1 to 4 y is zero, or an integer of from 1 to 2 z is zero, or an integer of from 1 to 4; and u + v + w + x + y + z is an integer of from 1 to 22; the subgroups within the group (2) being in any sequence; provided that when the subgroup (CH=CH) is present, then the total number of carbon atoms in said group (2) will be from 10 to 22.