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EP0336309A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

A selective or sequential access analyzer for clinico-chemical analyses and for immunological tests

Assignee: POLI-MAK SpA
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Filing: 1989-03-31
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Granted: —
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Expires: 2009-03-31
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Abstract

Abstract A selective or sequential access analyzer for clinico-chemical analyses and for immunological tests, which includes a central microprocessor, a diluting device (7) connected to a revolving sampling system (13) or assembly and provided with a sampling probe (12)= a fixed reagent-supporting tray (14) concentrically external with respect to said sampling assembly= a first revolving sample bearing plate (17) in such a position as to be within the reach or of said sampling probe= a second revolving plate, independent of the first one, and concentrically external to the same provided with segments (19) bearing reaction test-tubes (20) and placed in such a way as to be within the reach of said sampling probe= an aspiration system (21) bearing a probe (23) is provided diametrically opposite to said sampling assembly with respect to said two concentric plates= and a reading photometer (25) connected to said aspiration probe through a tube= said analyzer also includes six microprocessors operatively interconnected to each other and to the central microprocessor, respectively, for the diluting device, for the sampling assembly, the first revolving plate, the second revolving plate, the aspiration probe and the reading photometer while the motion of said diluting device, of the sampling assembly, of the first and the second revolving plates, of the aspiration probe and the reading photometer is obtained through stepper motors controlled by the individual microprocessors for each of these elements.

Inventors

  • 👤 Henry Hugh Welch

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-30 09:32
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/02; G01N35/025; G01N1/00; G01N1/28; G01N1/38; G01N2001/383; G01N35/04; G01N2035/0439; G01N2035/0446; G01N2035/0448; G01N2035/0453; G01N2035/0455; G01N35/10; G01N2035/1027; G01N2035/1032; G01N35/1004

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 342 words
A clinical analyzer (1) for opening performing clinico-chemistry analyses and immunological tests on patient samples, said analyzer including: a mechanical frame support (32)= a rotatable stage assembly(64) mounted on the support (32) having means for holding patient samples in sample cups (18) and means (19) for holding test tubes (20) thereon= a test preparation station (62) disposed adjacent the rotatable stage assembly (64) including a reagent supply (16) and a sample probe assembly (13) for delivering measured quantities of at least one reagent and a patient sample to a test tube (20) to form a reaction mixture= and a testing station (62) adjacent the rotatable stage assembly (64) including a photometer assembly (25) having a cuvette (43) and an aspirator probe assembly (21 for transferring the reaction mixture from the test tube (20) to the cuvette (43) for photometric measurement= and the improvement comprising: said test preparation station (60) and said testing station (62) beng located adjacent the rotatable stage assembly (64) on diametrically opposed sides thereof- said rotatable stage assembly (64) including an inner rotatable sample-bearing plate (17) and a second outer concentric independently-rotatable test tube-bearing plate (66)= a first test-tube (20) in a test tube holder (19) on said test tube-bearing plate (66) being dedicated as a wash test tube (20)= means (7) for delivery wash solution to said wash test tube (20)= programmable driver means (36) for combatting rotation of the sample bearing plate (17)= programmable drive means (35) for controlling rotation of the test tube-bearing plate (66) and central processor control means (68) for coordinating the actions of each said programmable driver means (35, 36)= whereby, independent movements of the sample-bearing plate (17) and said test tube-bearing plate (66) into and out of said test preparation station (60) and said testing station (62) permit testing to be performed sequentially with the same test being performed on a number of patient samples and permit testing to be performed randomly with a number of different tests being performed per patient sample in any order for at least one patient sample.
Claim 2
Dependent Claim 342 words
A clinical analyzer (1) for opening performing clinico-chemistry analyses and immunological tests on patient samples, said analyzer including: a mechanical frame support (32)= a rotatable stage assembly(64) mounted on the support (32) having means for holding patient samples in sample cups (18) and means (19) for holding test tubes (20) thereon= a test preparation station (62) disposed adjacent the rotatable stage assembly (64) including a reagent supply (16) and a sample probe assembly (13) for delivering measured quantities of at least one reagent and a patient sample to a test tube (20) to form a reaction mixture= and a testing station (62) adjacent the rotatable stage assembly (64) including a photometer assembly (25) having a cuvette (43) and an aspirator probe assembly (21 for transferring the reaction mixture from the test tube (20) to the cuvette (43) for photometric measurement= and the improvement comprising: said test preparation station (60) and said testing station (62) beng located adjacent the rotatable stage assembly (64) on diametrically opposed sides thereof- said rotatable stage assembly (64) including an inner rotatable sample-bearing plate (17) and a second outer concentric independently-rotatable test tube-bearing plate (66)= a first test-tube (20) in a test tube holder (19) on said test tube-bearing plate (66) being dedicated as a wash test tube (20)= means (7) for delivery wash solution to said wash test tube (20)= programmable driver means (36) for combatting rotation of the sample bearing plate (17)= programmable drive means (35) for controlling rotation of the test tube-bearing plate (66) and central processor control means (68) for coordinating the actions of each said programmable driver means (35, 36)= whereby, independent movements of the sample-bearing plate (17) and said test tube-bearing plate (66) into and out of said test preparation station (60) and said testing station (62) permit testing to be performed sequentially with the same test being performed on a number of patient samples and permit testing to be performed randomly with a number of different tests being performed per patient sample in any order for at least one patient sample.
Claim 3
Dependent Claim 26 words
A clinical analyzer as in claim 1 wherein each of said programmable drive means (35, 36) comprises a combination of a stepper motor and microprocessor therefor.
Claim 4
Dependent Claim 52 words
A clinical analyzer as in claim 1 wherein said test preparation station (60) further includes an annular reagent-bearing tray (14) concentrically external to said sample probe assembly (13) having spaced-apart reagent bottle holders (15) therein for receiving a plurality of open-topped reagent bottles (16) and holding them at a canted outward angle.
Claim 5
Dependent Claim 211 words
A clinical analyzer as in claim 1 wherein said sample probe assembly (13) comprises a rotatable base (70) mounted to said frame (32), a vertical arm member (72) extending upwardly from said base (70) to an upper end, a sample arm (11) extending normally from one side of said vertical arm (72) to an opposed free and, said sample arm (11) being mounted for vertical movement along said vertical arm (72), and a sample prove (12) extending toward said base (70) from the free end of the sample arm (11)= programmable drive means (27) for raising and lowering the sample arm (11) along the vertical arm (72) and programmable drive means (34) for rotating the sample probe assembly (13) between a reagent draw position wherein the sample probe (12) is aligned with one of said reagent bottle (16) in said reagent bearing tray (14), a wash position wherein the sample probe (12) is aligned with said wash test tube (20) on said test tube-bearing plate (66), a sample draw position wherein the sample probe (12) is aligned with a patient sample cup (18) positioned on said sample-bearing plate (17) and dispense position wherein the sample probe (12) is aligned with another test tube (20′) positioned on said test tube-bearing plate (66).
Claim 6
Dependent Claim 143 words
A clinical analyzer as in claim 4 further comprising a diluting assembly (7), said diluting assembly (7) including a syringe (59) with a plunger (80) at one end and connected to a valve means (9) at the opposed inlet/outlet end (82), said valve means (9) being connected by tubing (58) to a supply of wash solution and being connected by tubing (10) to said sample probe (12)= valve control means for controlling which tubing (58, 10) is in communication with the inlet/outlet opening (82)= and programmable activator means (54, 56) for moving the plunger (80) within the syringe (59) to draw measured amounts of fluid from the wash water supply (8), a reagent bottle (16) or a patient sample (18), respectively, and to dispense same form the sample probe (12) into said wash test tube (20′) or another of said test tubes (20).
Claim 7
Dependent Claim 100 words
A clinical analyzer as in claim 1 wherein said aspirator probe assembly (21) comprises an aspirator needle (23) mounted for vertical movement at said testing station (62), said aspirator needle (23) positioned to be aligned with a test tube (20) on said test tube-bearing plate (66) in said testing station (62), programmable drive means (31) for raising and lowering the aspirator needle (23) into and out of a test tube (20) positioned in the testing station (62) and aspirator means connected to said needle (23) for aspirating the reaction mixture from the test tube (20) and into the cuvette (43).
Claim 8
Dependent Claim 105 words
A clinical analyzer as N claim 4, wherein the programmable drive means (27) for raising and lowering the sample arm (11) comprises a worm gear (56) rotatably mounted to said vertical arm (72), a slider (55) mounted for travel on said worm gear (56) upon rotation thereof, said sample arm (11) being mounted to said slider (55), a stepper motor (27) and microprocessor therefor and a drive belt connecting the stepper motor (27) to said worm gear (56) and said programmable drive means (34) for rotating the sample probe assembly (13) comprises a stepper motor (34) connected to said base (70) and a microprocessor control.
Claim 9
Independent Claim 258 words
A method for chemically analyzing at least one patient sample on automated equipment comprising (a) providing a moveable sample prove assembly (13) capable of drawing and dispensing measured amounts of fluid through a sample probe (12)= (b) providing a wash water supply (8), a reagent supply (16), patient sample supply (18) and a supply of test tubes (20) within the reach of said moveable sample probe assembly (13)= (c) dispensing wash solution through said probe (12) into a wash test tube to rinse the inside of the probe= (d) removing the wash solution from the wash test tube= (e) again dispensing wash solution through said probe into the wash test tube= (f) drawing a measured amount of reagent from said reagent supply into said sample probe= (g) rinsing said probe by immersing it in said wash test tube= (h) drawing a measured amount of patient sample into the sample probe= (i) rinsing said sample probe by immersing it in said wash test tube= (j) dispensing the measured reagent and sample from the sample probe into another test tube to form a reaction mixture= (k) rinsing the sample probe by immersing it in said wash test tube= (l) permitting the reaction mixture to react until the reaction is substantially complete= (m) subjecting the reaction mixture to photometric analysis to obtain information regarding the chemical composition of the patient sample= and repeating steps (c)-(m) as necessary until all analyses for that patient same are complete or until the same analysis has been performed on a total number of patient samples.
Claim 10
Independent Claim 258 words
A method for chemically analyzing at least one patient sample on automated equipment comprising (a) providing a moveable sample prove assembly (13) capable of drawing and dispensing measured amounts of fluid through a sample probe (12)= (b) providing a wash water supply (8), a reagent supply (16), patient sample supply (18) and a supply of test tubes (20) within the reach of said moveable sample probe assembly (13)= (c) dispensing wash solution through said probe (12) into a wash test tube to rinse the inside of the probe= (d) removing the wash solution from the wash test tube= (e) again dispensing wash solution through said probe into the wash test tube= (f) drawing a measured amount of reagent from said reagent supply into said sample probe= (g) rinsing said probe by immersing it in said wash test tube= (h) drawing a measured amount of patient sample into the sample probe= (i) rinsing said sample probe by immersing it in said wash test tube= (j) dispensing the measured reagent and sample from the sample probe into another test tube to form a reaction mixture= (k) rinsing the sample probe by immersing it in said wash test tube= (l) permitting the reaction mixture to react until the reaction is substantially complete= (m) subjecting the reaction mixture to photometric analysis to obtain information regarding the chemical composition of the patient sample= and repeating steps (c)-(m) as necessary until all analyses for that patient same are complete or until the same analysis has been performed on a total number of patient samples.

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