EP0335972A1
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EP
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Medical material and process for its production
Assignee: Asahi Kasei Medical Co Ltd
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Filing: 1987-11-13
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Granted: —
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Expires: 2007-11-13
Abstract
Abstract A medical material showing a high and stable biocompatibility for a long time and a process for its production. The medical material comprises a base material composed of a polymer composed of repeating units having a functional group to which are bound macromers having a fat-soluble vitamin, a saturated or unsaturated fatty acid residue at one end thereof through the other reactive terminal group thereof to form a graft layer.
Inventors
- 👤 Nobuyoshi Kashiwagi
- 👤 Masatomi Sasaki
- 👤 Hirotomo Morita
- 👤 Rieko Soeno
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 22:51
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/0005; A61L33/0076; A61L33/0082; C; C08; C08L; C08L1/00
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
73 words
A medical material characterized by possessing on the surface of a substrate made of a polymer possessing functional group-containing repeating units a graft polymer formed by causing a macromer possessing at one of the opposite terminals thereof a fat-soluble vitamin, a saturated fatty acid, or an unsaturated fatty acid residue to be bonded at the remaining reactive terminal thereof to said functional group of said polymer existing on said surface of said substrate.
Claim 2
Dependent Claim
73 words
A medical material characterized by possessing on the surface of a substrate made of a polymer possessing functional group-containing repeating units a graft polymer formed by causing a macromer possessing at one of the opposite terminals thereof a fat-soluble vitamin, a saturated fatty acid, or an unsaturated fatty acid residue to be bonded at the remaining reactive terminal thereof to said functional group of said polymer existing on said surface of said substrate.
Claim 3
Dependent Claim
25 words
A medical material according to Claim 1, wherein said functional group is selected from the class consisting of hydroxyl group, amino group, and carboxyl group.
Claim 4
Dependent Claim
15 words
A medical material according to Claim 2, wherein said functional group is a hydroxyl group.
Claim 5
Dependent Claim
17 words
A medical material according to Claim 3, wherein said polymer is regenerated cellulose or a cellulose derivative.
Claim 6
Dependent Claim
32 words
A medical material according to any of Claims 1 to 4, wherein said fat-soluble vitamin is selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, and ubiquinone.
Claim 7
Dependent Claim
14 words
A medical material according to Claim 5, wherein said fat-soluble vitamin is vitamin E.
Claim 8
Dependent Claim
34 words
A medical material according to any of Claims 1 to 4, wherein said saturated fatty acid is selected from the group consisting of laurylic acid, myristic acid, pentadylic acid, palmitic acid, and stearic acid.
Claim 9
Dependent Claim
15 words
A medical material according to Claim 7, wherein said saturated fatty acid is myristic acid.
Claim 10
Dependent Claim
15 words
A medical material according to Claim 7, wherein said saturated fatty acid is palmitic acid.
Claim 11
Dependent Claim
38 words
A medical material according to any of Claims 1 to 4, wherein said unsaturated fatty acid is selected from the group consisting of stearic acid, elaidic acid, oleic acid, linolic acid, linolenic acid, arachidonic acid, and eicosapentaeic acid.
Claim 12
Dependent Claim
15 words
A medical material according to Claim 10, wherein said unsaturated fatty acid is linolic acid.
Claim 13
Dependent Claim
15 words
A medical material according to Claim 10, wherein said unsaturated fatty acid is linolenic acid.
Claim 14
Dependent Claim
22 words
A medical material according to any of Claims 1 to 12, wherein said reactive terminal of said macromer is an epoxy group.
Claim 15
Dependent Claim
37 words
A medical material according to Claim 13, wherein said macromer is formed of a linear diglycidyl ether derivative possessing at one of the opposite terminal thereof a fat-soluble vitamin, saturated fatty acid, or unsaturated fatty acid residue.
Claim 16
Dependent Claim
17 words
A medical material according to Claim 14, wherein said linear diglycidyl ether is 1,4-butane diol diglycidyl ether.
Claim 17
Dependent Claim
42 words
A medical material according to any of Claims 1 to 13, wherein said macromer is formed of at least one alkylene glycol skeleton possessing at one of the opposite terminals thereof a fat-soluble vitamin, saturated fatty acid, or unsaturated fatty acid residue.
Claim 18
Dependent Claim
16 words
A medical material according to Claim 16, wherein said other reactive terminal is an epoxy group.
Claim 19
Dependent Claim
16 words
A medical material according to Claim 16, wherein said other reactive terminal is a hydroxyl group.
Claim 20
Dependent Claim
26 words
A medical material according to any of Claims 16 to 18, wherein said alkylene glycol has a polymerization degree in the range of 1 to 100.
Claim 21
Dependent Claim
18 words
A medical material according to any of Claims 16 to 19, wherein said alkylene glycol is polyethylene glycol.
Claim 22
Dependent Claim
18 words
A medical material according to any of Claims 16 to 19, wherein said alkylene glycol is polypropylene glycol.
Claim 23
Independent Claim
75 words
A method for the production of a medical material characterized by (a) forming a macromer possessing at one of the opposite terminals thereof a fat-soluble vitamin, a saturated fatty acid, or an unsaturated fatty acid residue and (b) causing the other reactive terminal of said macromer to be bonded, on a substrate made of a polymer possessing functional group-containing repeating unit, to said functional group of said polymer existing on the surface of said substrate.
Claim 24
Independent Claim
75 words
A method for the production of a medical material characterized by (a) forming a macromer possessing at one of the opposite terminals thereof a fat-soluble vitamin, a saturated fatty acid, or an unsaturated fatty acid residue and (b) causing the other reactive terminal of said macromer to be bonded, on a substrate made of a polymer possessing functional group-containing repeating unit, to said functional group of said polymer existing on the surface of said substrate.
Claim 25
Dependent Claim
28 words
A method for the production of a medical material according to Claim 22, wherein said macromer to be formed possesses an epoxy group as said other reactive terminal.
Claim 26
Dependent Claim
51 words
A method for the production of a medical material according to Claim 22 or Claim 23, wherein said macromer is formed by causing the reactive group at one of the opposite terminals thereof to react selectively with the functional group of said fat-soluble vitamin, saturated fatty acid, or unsaturated fatty acid.
Claim 27
Dependent Claim
19 words
A method for the production of a medical material according to Claim 24, wherein said macromer precursor is diepoxide.
Claim 28
Dependent Claim
21 words
A method for the production of a medical material according to Claim 25, wherein said diepoxide is a linear diglycidyl ether.
Claim 29
Dependent Claim
23 words
A method for the production of a medical material according to Claim 26, wherein said linear diglycidyl ether is 1,4-butane diol diglycidyl ether.
Claim 30
Independent Claim
28 words
A method for the production of a medical material according to any of Claims 23 to 26, wherein said macromer precursor possesses at least one alkylene glycol skeleton.
Claim 31
Independent Claim
35 words
A method for the production of a medical material according to any of Claims 23 to 28, wherein the functional group of said fat-soluble vitamin, saturated fatty acid, or unsaturated fatty acid is carboxyl group.
Claim 32
Independent Claim
29 words
A method for the production of a medical material according to any of Claims 23 to 28, wherein the functional group of said fat-soluble vitamin is a hydroxyl group.
Claim 33
Independent Claim
69 words
A method for the production of a medical material according to any of Claims 22 to 30, wherein said macromer is bonded to the surface of said substrate by bringing said macromer into contact in a liquid state or a gaseous state with the surface of said substrate thereby allowing the functional group on the surface of said substrate to react with the other reactive terminal of said macromer.
Claim 34
Independent Claim
83 words
A method for the production of a medical material according to any of Claims 23 to 31, wherein said macromer is bonded to the surface of said substrate by bringing said macromer into contact in a liquid state with the surface of said substrate possessing a functional OH group in the presence of a Friedel-Crafts type catalyst or an alkali catalyst thereby enabling the reactive epoxy terminal of said macromer to react with the functional OH group on the surface of said substrate.
Claim 35
Dependent Claim
21 words
A method for the production of a medical material according to Claim 32, wherein said Friedel-Crafts type catalyst is boron trifluoride.
Claim 36
Dependent Claim
23 words
A method for the production of a medical material according to Claim 32, wherein said alkali catalyst is sodium hydroxide or potassium hydroxide.
Claim 37
Independent Claim
36 words
A method for the production of a medical material according to any of Claims 31 to 34, wherein one member selected from the group consisting of dioxane, acetone, and methylethyl ketone is used as a solvent.
References Cited (Backward Citations)
No citation records indexed.
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