EP0335560A2
Expired / Lapsed
EP
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Controlled release pharmaceutical preparation and method for producing the same
Assignee: Tanabe Pharma Corp
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Filing: 1989-03-21
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Granted: —
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Expires: 2009-03-21
Abstract
Abstract Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Also disclosed is a method for producing the same.
Inventors
- 👤 Masayoshi Samejima
- 👤 Kazuo Noda
- 👤 Yoshiyuki Hirakawa
- 👤 Hiroyuki Yoshino
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 18:56
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
41 words
A controlled release pharmaceutical preparation characterised by a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, said core being coated with said porous film.
Claim 2
Dependent Claim
41 words
A controlled release pharmaceutical preparation characterised by a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, said core being coated with said porous film.
Claim 3
Dependent Claim
20 words
A preparation according to claim 1, characterised in that the porous film has a porosity of about 0.4 to 0.9.
Claim 4
Dependent Claim
20 words
A preparation according to claim 2, characterised in that the porous film has a porosity of about 0.5 to 0.85.
Claim 5
Dependent Claim
34 words
A preparation according to any of claims 1 to 3, wherein the porous film comprises 0.05 to 0.5 part by weight of hydrophilic polymeric substance per 1 part by weight of hydrophobic polymeric substance.
Claim 6
Dependent Claim
44 words
A preparation according to any of claims 1 to 4, characterised in that the hydrophobic polymeric substance is at least one selected from the group consisting of cellulose ether, cellulose ester, polyvinyl ester and an acrylic acid polymer having a quaternary ammonium alkyl group.
Claim 7
Dependent Claim
45 words
A preparation according to any of claims 1 to 5, characterised in that the hydrophilic substance is at least one selected from the group consisting of water soluble polymeric substances, enteric polymeric substances, gastric soluble polymeric substances and both gastric soluble and enteric polymeric substances.
Claim 8
Dependent Claim
162 words
A preparation according to claim 6, wherein the water-soluble polymeric substance is at least one selected from the group consisting of polysaccharides which optionally having sulfuric acid group, polysaccharides having hydroxyalkyl group, polysaccharides having carboxyalkyl group, methyl cellulose polyvinyl pyrrolidone, polyvinyl alcohol and polyethylene glycol, the enteric polymeric substance is at least one selected from the group consisting of carboxyalkyl cellulose, cellulose derivative having monoester bond of dibasic acid, polyvinyl derivative having monoester bond of dibasic acid, maleic acid-vinyl copolymer and acrylic acid type polymer; the gastric soluble polymeric substance is at least one selected from the group consisting of cellulose derivative having mono- or di-substituted amino group, polyvinyl derivative having mono- or di-substituted amino group and acrylic acid polymer having mono-substituted amino group; and both the gastic soluble and enteric polymeric substance is at least one selected from the group consisting of vinyl pyridine-acrylic acid type copolymer, carboxymethyl polysaccharides having mono- or di-substituted amino group and polyvinyl amino acid type derivative.
Claim 9
Dependent Claim
22 words
A preparation according to any of claims 1 to 7, characterised in that the porous film comprises ethyl cellulose and hydroxypropyl cellulose.
Claim 10
Dependent Claim
27 words
A preparation according to any of claims 1 to 8, characterised in that an organic acid is contained together with the pharmaceutical active ingredient in the core.
Claim 11
Dependent Claim
13 words
A preparation according to claim 9, wherein the organic acid is succinic acid.
Claim 12
Independent Claim
57 words
A method for producing a controlled release pharmaceutical preparation, which comprises spray coating a core containing a pharmaceutically active ingredient with a water-organic solvent mixture containing a hydrophobic polymeric substance of a hydrophobic polymeric substance and a hydrophilic polymeric substance to form a porous film comprising said polymeric substance or substances on the surface of the core.
Claim 13
Independent Claim
57 words
A method for producing a controlled release pharmaceutical preparation, which comprises spray coating a core containing a pharmaceutically active ingredient with a water-organic solvent mixture containing a hydrophobic polymeric substance of a hydrophobic polymeric substance and a hydrophilic polymeric substance to form a porous film comprising said polymeric substance or substances on the surface of the core.
References Cited (Backward Citations)
No citation records indexed.
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