EP0331774A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Crack prevention of implanted prostheses
Assignee: Corvita Corp
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Filing: 1988-03-08
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Granted: —
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Expires: 2008-03-08
Abstract
Abstract Implantable devices for medical use are provided which have been subjected to treatment with a crack preventative composition that include a silicone rubber such as poly(dimethyl siloxane). This treatment substantially prevents cracking of the implantable device after it is implanted.
Inventors
- 👤 Leonard Pinchuk
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 18:17
CPC Classifications
A; A61; A61L; A61L17/00; A61L17/14; A61L17/145; A61L27/00; A61L27/28; A61L27/34
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
161 words
A method for forming an implantable device for medical use, which device is treated to substantially prevent in vivo cracking thereof, the method comprising: providing a non-woven shaped substrate of an implantable medical device having a biocompatible polymer surface that is susceptible to cracking when subjected to implantation under in vivo conditions for substantial time periods, said in vivo conditions including those that promote crackforming biodegration of said biocompatible polymeric surface, said non-woven shaped substrate including wound strands of extrude fiber that overlie and intersect one another; applying a crack preventative composition to said biocompatible polymeric surface, said crack preventative compostion including a silicone rubber material being a siloxane including -O-Si-O- groups and having a predetermined surface tension, said applying step including effecting adsorption of the silicone rubber material onto biocompatible polymeric surface; and said providing step includes selecting said biocompatible polymeric surface to have a surface tension that is greater than the predetermined ten sion of said silicone rubber material.
Claim 2
Independent Claim
161 words
A method for forming an implantable device for medical use, which device is treated to substantially prevent in vivo cracking thereof, the method comprising: providing a non-woven shaped substrate of an implantable medical device having a biocompatible polymer surface that is susceptible to cracking when subjected to implantation under in vivo conditions for substantial time periods, said in vivo conditions including those that promote crackforming biodegration of said biocompatible polymeric surface, said non-woven shaped substrate including wound strands of extrude fiber that overlie and intersect one another; applying a crack preventative composition to said biocompatible polymeric surface, said crack preventative compostion including a silicone rubber material being a siloxane including -O-Si-O- groups and having a predetermined surface tension, said applying step including effecting adsorption of the silicone rubber material onto biocompatible polymeric surface; and said providing step includes selecting said biocompatible polymeric surface to have a surface tension that is greater than the predetermined ten sion of said silicone rubber material.
Claim 3
Dependent Claim
63 words
The treatment method according to claim 1 wherein said silicone rubber material of the crack preventative composition is a siloxane condensation reaction product of reactants including: a) a silicone moiety of the formula: wherein n has an average value of greater than 100; and b) an acetoxy silane crosslinker of the formula: R-Si O- -CH₃) p wherein p is 1, 2 or 3.
Claim 4
Dependent Claim
24 words
The treatment method according to claim 1 wherein said crack preventative composition includes a solvent that does not detrimentally affect said biocompatible polymeric surface.
Claim 5
Dependent Claim
25 words
The treatment method according to claim 1 wherein said shaped substrate includes one or more extruded fibers that are shaped by winding over a mandrel.
Claim 6
Dependent Claim
20 words
The treatment method according to claim 1, wherein said applying step includes imparing lubricating properties to the biocompatible polymeric surface.
Claim 7
Dependent Claim
15 words
The treatment method according to claim 1, wherein said biocompatible polymeric surface is a polyurethane.
Claim 8
Dependent Claim
119 words
The forming method according to claim 1, wherein said silicone rubber material of the crack preventative composition is a siloxane which, prior to curing, has the formula: wherein each group is an organic moiety selected from the group consisting of one or more ester moieties, acetoxy moieties, acrylic moieties and alcohol moieties, wherein each R₃ and R₄ group is an organic group selected from the group consisting of aliphatic groups and substituted aliphatic groups having from 1 to about 12 carbon atoms, and aromatic groups and substituted aromatic groups having from 6 to about 20 carbon atoms, and wherein each R₁ group and R₂ group is an organic component selected from the group consisting of R, R₃ and R₄.
Claim 9
Dependent Claim
20 words
The forming method according to claim 1, wherein said silicone rubber material of the crack preventative composition is poly(dimethyl siloxane).
Claim 10
Dependent Claim
20 words
The treatment method according to claim 1, wherein said shaped substrate includes one or more strands of said biocompatible polymer.
Claim 11
Dependent Claim
106 words
An implantable device for medical use under in vivo conditions, comprising: a shaped substrate of an implantable medical device having a biocompatible polymeric surface that is suspectible to biodegradation cracking when subjected to implantation under in vivo conditions for substantial time periods, said shaped substrate including wound strands of extruded fiber that overlie and intersect one another; a crack preventative adsorbed to said substrate, said crack preventative being a silicone rubber material having a predetermined surface tension, said crack preventative being a siloxane including recurring -O-Si-O- groups; and said biocompatible polymer surface has a surface tension greater than the predetermined surface tension of the crack preventative.
Claim 12
Dependent Claim
106 words
An implantable device for medical use under in vivo conditions, comprising: a shaped substrate of an implantable medical device having a biocompatible polymeric surface that is suspectible to biodegradation cracking when subjected to implantation under in vivo conditions for substantial time periods, said shaped substrate including wound strands of extruded fiber that overlie and intersect one another; a crack preventative adsorbed to said substrate, said crack preventative being a silicone rubber material having a predetermined surface tension, said crack preventative being a siloxane including recurring -O-Si-O- groups; and said biocompatible polymer surface has a surface tension greater than the predetermined surface tension of the crack preventative.
Claim 13
Dependent Claim
114 words
The implantable device according to claim 10 wherein said crack preventative is a siloxane which, prior to curing, has the formula: wherein each R group is an organic moiety selected from the group consisting of one or more ester moieties, acetoxy moieties, acrylic moieties and alcohol moieties, wherein each R₃ and R₄ group is an organic group selected from the group consisting of aliphatic groups and substituted aliphatic groups having from 1 to 12 carbon atoms, and aromatic groups and substituted aromatic groups having from 6 to about 20 carbon atoms, and wherein each R₁ group and R₂ group is an organic component se lected from the group consisting of R, R₃ and R₄.
Claim 14
Dependent Claim
19 words
The implantable device according to claim 10 wherein said siliconerubber material of the crack preventative compostion is poly(dimethyl siloxane).
Claim 15
Dependent Claim
20 words
The implantable device according to claim 10 wherein said shaped substrate includes one or more strands of said biocompatible polymer.
Claim 16
Dependent Claim
25 words
The implantable device according to claim 10 wherein said shaped substrate includes one or more extruded fibers that are shaped by winding over a mandrel.
Claim 17
Dependent Claim
44 words
The implantable device according to claim 10 wherein said biocompatible polymeric surface is a polymer selected from the group consisting of a polyurethane, a poly(fluorosilicone urethane) copolymer, a polypropylene, an acrylate polymer, and other polymers having a surface tension greater than about 18 Dynes/cm.
Claim 18
Dependent Claim
15 words
The implantable device according to claim 10 wherein said shaped substrate is a vascular graft.
Claim 19
Dependent Claim
14 words
The implantable device according to claim 10 wherein said shaped substrate is a suture.
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