EP0326151A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Improved controlled release formulation
Assignee: Koken Co Ltd
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Filing: 1989-01-27
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Granted: —
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Expires: 2009-01-27
Abstract
Abstract A controlled release formulation which comprises an organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis together with an active ingredient and collagen as a carrier, said formulation being capable of exhibiting a predetermined release profile of the active ingredient. A process for producing said formulation is also provided.
Inventors
- 👤 Keiji Sumitomo Pharmaceuticals Co. Ltd. Fujioka
- 👤 Shigeji Sumitomo Pharmaceuticals Co. Ltd. Sato
- 👤 Nobuhiko Sumitomo Pharmaceuticals Co. Ltd Tamura
- 👤 Yoshihiro Sumitomo Pharmaceuticals Co. Ltd Takada
- 👤 Yoshio C/O Sumitomo Pharmaceuticals Co.Ltd Sasaki
- 👤 Miho C/O Sumitomo Pharmaceuticals Co.Ltd Maeda
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 09:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063; A61K47/00; A61K47/06; A61K47/08; A61K47/12; A61K47/16; A61K47/18; A61K47/183; A61K47/30; A61K47/42; A61K9/2013
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
44 words
A sustained release formulation comprising an active ingredient and collagen as a carrier, characterized in that it comprises in the formulation at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
Claim 2
Dependent Claim
44 words
A sustained release formulation comprising an active ingredient and collagen as a carrier, characterized in that it comprises in the formulation at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
Claim 3
Dependent Claim
10 words
The formulation of Claim 1, wherein the collagen is atelocollagen.
Claim 4
Dependent Claim
16 words
The formulation of Claim 1, wherein the active ingredient is selected from bioactive proteins and peptides.
Claim 5
Dependent Claim
25 words
The formulation of Claim 3, wherein the bioactive proteins and peptides are selected from cytokines, hormones, hormone-releasing factors, hormone release-inhibiting factors, growth factors and enzymes.
Claim 6
Dependent Claim
16 words
The formulation of Claim 4, wherein the cytokines are selected from interleukins, interferons, and colony-stimulating factors.
Claim 7
Dependent Claim
13 words
The formulation of Claim 4, wherein the hormones are growth hormone and calcitonin.
Claim 8
Dependent Claim
17 words
The formulation of Claim 4, wherein the hormone-releasing factors are growth hormone-releasing factors and luteinizing hormone-releasing hormone.
Claim 9
Dependent Claim
12 words
The formulation of Claim 4, wherein the hormone release-inhibiting factor is somatostatine.
Claim 10
Dependent Claim
31 words
The formulation of Claim 4, wherein the growth factors are selected from somatomedin, nerve growth factor, epidermal growth factor, transforming growth factor, fibroblast growth factor, erythropoietin (EPO) and platelet-derived growth factor.
Claim 11
Dependent Claim
14 words
The formulation of Claim 4, wherein the enzymes are tissue plasminogen activator and urokinase.
Claim 12
Dependent Claim
18 words
The formulation of Claim 1, wherein the organic acidic compound is a compound bearing carboxylic group or groups.
Claim 13
Dependent Claim
30 words
The formulation of Claim 1, wherein the organic acidic compound is selected from aspartic acid, glutamic acid, glycine, alanine, citric acid, ascorbic acid, tartaric acid, succinic acid and acetic acid.
Claim 14
Dependent Claim
25 words
The formulation of Claim 1, wherein the active ingredient is growth hormone-releasing factor and the organic acidic compound is selected from citric acid and glycine.
Claim 15
Dependent Claim
24 words
The formulation of Claim 1, wherein the active ingredient is an interferon and the organic acidic compound is selected from citric acid and glycine.
Claim 16
Dependent Claim
19 words
The formulation of Claim 1, wherein the active ingredient is calcitonin and the organic acidic compound is citric acid.
Claim 17
Dependent Claim
68 words
A process for producing a sustained release formulation comprising an active ingredient and collagen as a carrier, said formulation exhibiting a predetermined release profile of the active ingredient, which process comprises a step to incorporate into a mixture of other starting materials for the formulation at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
Claim 18
Dependent Claim
68 words
A process for producing a sustained release formulation comprising an active ingredient and collagen as a carrier, said formulation exhibiting a predetermined release profile of the active ingredient, which process comprises a step to incorporate into a mixture of other starting materials for the formulation at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
Claim 19
Independent Claim
55 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen and said active ingredient, characterized in that said composition comprises additionally at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
Claim 20
Independent Claim
55 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen and said active ingredient, characterized in that said composition comprises additionally at least one organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis.
References Cited (Backward Citations)
No citation records indexed.
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