Cytostatic titanocene derivatives and pharmaceuticals containing them

Abstract

Abstract Titanocene derivatives of the general formulae I and II: <IMAGE> in which: A denotes a ligand of the formula: -N IDENTICAL C-R in which R is an alkyl group having 1 to 6 carbon atoms, or -X-AR in which X is an oxygen, sulphur or selenium atom and Ar denotes a phenyl group which is unsubstituted or substituted by halogen or NO2, where Ar cannot be an unsubstituted phenyl group if X is a sulphur atom; B denotes a halide or is defined as the ligand A; or A and B together represent a bidentate ligand from the group comprising: <IMAGE> where R is as defined above, R' denotes identical or different H or R and b is the number 1 or 2; and Y denotes an anion which is present if the titanium complex is positively charged, where a denotes the number necessary to balance the charge of the total complex; <IMAGE> in which R is defined as in Claim 1, Y' denotes a cation and a is the number necessary to balance the charge of the total complex; are active chemotherapeutics having cytostatic action.

Inventors

• 👤 Petra Prof. Dr. Köpf-Maier

Bibliographic Details