Amino acid composition for parenteral nutritional support

Abstract

Abstract The invention relates to a composition for thera­peutic, especially postoperative and posttraumatic, parenteral nutritional support treatment, which compo­sition is based on a conventional amino acid mixture, the composition being characterised in that it also includes L- glutamine and/or alpha-ketoglutarate and optionally L- asparagine, the components of the composi­tion, expressed in g dry component/l aqueous solution, being: glycine (1-12), aspartate (1-10), glutamate (2-12), alanine (2-20), arginine (2-14), cysteine/­cystine (0.4-2.0), histidine (2-8), isoleucine (2-8), leucine (2-8), lysine (2-12), methionine (1-6), phenyl­alanine (4-10), proline (4-10), serine (2-10), threonine (2-8), tryptophan (1-3), tyrosine (0.2-1), valine (2-8), and additionally 5-30 g/l L-glutamine and/or 5-25 g/l alpha-ketoglutarate, and optionally 0.5-10 g/l L-asparagine and/or acetoacetate, or salts or esters thereof. The invention also relates to the use of L-glutamine and/or its derivative alpha-ketoglutarate, and optionally L-asparagine and/or its derivative acetoacetate for the preparation of a composition intended for therapeutic, especially postoperative and posttraumic, parenteral nutritional support treatment, which use is characterised in that L-glutamine and/or alpha-keto­glutarate and optionally L-asparagine and/or acetoace­tate, dissolved in water and sterile-filtered, are added in cold-stored and freeze-dried form or other sterile powder form to a commercial amino acid nutrient solution immediately before the therapeutic treatment.

Inventors

• 👤 Erik Vinnars

Bibliographic Details