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EP0318281A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Use of dsRNA in the prevention of viral escape

Assignee: HEM Pharmaceuticals Corp
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Filing: 1988-11-24
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Granted: —
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Expires: 2008-11-24
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Abstract

Abstract dsRNA reduces the phenomenon of viral escape and cellular damage attendant thereto. Viral escape is a process by which a virus or intracellular pathogen alters its host range or indirectly alters its susceptibility to antiviral or immunological therapies. Viruses do so by causing specific changes in their genomic/antigenic composition and/or by causing the elaboration of factors which enhance destructiveness of cells and their ability to multiply progeny virus. Animals susceptible to viral infections and pathology secondary to antigenic drift may have damage reduced by exposing them to dsRNA which prevents or substantially minimizes viral escape brought about through these mechanisms of molecular rearrangement and/or elaboration of factors which break down the natural host defenses.

Inventors

  • 👤 William A. Carter

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-07 13:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P31/00; A61P31/12; A61P43/00; C; C07; C07H; C07H21/00

Claims Analysis

Total Claims: 13
Claim 1
Independent Claim 23 words
Use of a dsRNA for the manufacture of a medicament for rendering or maintaining a virus-infected animal susceptible to antiviral or immunological therapy.
Claim 2
Dependent Claim 23 words
Use of a dsRNA for the manufacture of a medicament for rendering or maintaining a virus-infected animal susceptible to antiviral or immunological therapy.
Claim 3
Independent Claim 36 words
A method of treating virus-infected animal cells in vitro to reduce or prevent viral escape comprising the step of treating the said cells with an amount of a dsRNA effective to reduce or prevent viral escape.
Claim 4
Independent Claim 36 words
A method of treating virus-infected animal cells in vitro to reduce or prevent viral escape comprising the step of treating the said cells with an amount of a dsRNA effective to reduce or prevent viral escape.
Claim 5
Dependent Claim 41 words
Use of a dsRNA for the manufacture of a medicament for the treatment of an animal susceptible to viral infection by protecting the animal against viral-induced pathology secondary to antigenic drift as evidenced by molecular rearrangement of the viral particle structure.
Claim 6
Dependent Claim 41 words
Use of a dsRNA for the manufacture of a medicament for the treatment of an animal susceptible to viral infection by protecting the animal against viral-induced pathology secondary to antigenic drift as evidenced by molecular rearrangement of the viral particle structure.
Claim 7
Dependent Claim 36 words
Use of a dsRNA for the manufacture of a medicament for the treatment of animals by fixing and isolating the molecular arrangement of a viral particle structure while maintaining the particle's molecular arrangement within predetermined limits.
Claim 8
Dependent Claim 36 words
Use of a dsRNA for the manufacture of a medicament for the treatment of animals by fixing and isolating the molecular arrangement of a viral particle structure while maintaining the particle's molecular arrangement within predetermined limits.
Claim 9
Dependent Claim 25 words
The use of any one of claims 1, 3 and 4, or the method of claim 2 in which the dsRNA is a mismatched dsRNA.
Claim 10
Dependent Claim 44 words
The use of any of claims 1, 3, 4 and 5 or the method of claim 2 in which the mismatched dsRNA is a complex of a polyinosinate and a polycytidylate containing from 1 in 5 to 1 in 30 uracil or guanidine bases.
Claim 11
Dependent Claim 30 words
The use of any one of claims 1, 3, 4, 5 and 6 or the method of claim 2 in which the mismatched dsRNA is rI n .r(C₂₉,G) n .
Claim 12
Dependent Claim 31 words
The use of any one of claims 1, 3, 4, 5, 6 and 7 or the method of claim 2 in which the mismatched dsRNA is rI n .r(C₁₁₋₁₄,U) n .
Claim 13
Dependent Claim 45 words
The use of any one of claims 1, 3, 4, 5, 6 7 and 8 of the method of claim 2 in which the dsRNA contains regions of bond breakage and the dsRNA exhibits the favourable therapeutic ratio property of rI n .r(C₁₁₋₁₄,U) n .

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