EP0315698A1
Expired / Lapsed
EP
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Thieno(triazolo)diazepine compounds and medicinal application of the same
Assignee: Tanabe Pharma Corp
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Filing: 1988-05-25
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Granted: —
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Expires: 2008-05-25
Abstract
Abstract A thienotriazolodiazepine compound represented by general formula (l), wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl. R 1 and R 3 which may be the same or different are each hydrogen or alkyl having 1 to 4 carbon atoms, R 2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl and R' is straight-chain or branched alkyl alkenyl or alkinyl having 6 to 18 carbon atoms, or a thienodiazepine compound represented by general formula (ll), wherein Ar, R 1 , R 2 and R' are as defined above, a pharmaceutically acceptable salt thereof, and a medicinal application thereof. These compounds are useful as a therapeutic agent for circulatory diseases and various diseases induced by a platelet activating factor. Further, the compound (ll) is also useful as an intermediate for synthesis of the compound (l).
Inventors
- 👤 Minoru Moriwaki
- 👤 Masao Abe
- 👤 Hiroshi Mikashima
- 👤 Tetsuya Tahara
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 10:08
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04; A; A61; A61P; A61P7/00; A61P9/00; A61P9/08; A61P9/10; C07D495/12; C07D495/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
75 words
A thienotriazolodiazepine compound of the formula: wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl; R 1 and R 3 are the same or different and each is hydrogen, alkyl having 1 to 4 carbon atoms; R 2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R 4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
75 words
A thienotriazolodiazepine compound of the formula: wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl; R 1 and R 3 are the same or different and each is hydrogen, alkyl having 1 to 4 carbon atoms; R 2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R 4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
23 words
A compound of claim 1 selected from the group consisting of 4-(2-chlorophenyl)-2-hexyl-9-methyl-6H-thieno[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(2-methylphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(2-methoxyphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-2-octyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(4-methylphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(3-methylphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(3,4,5-trimethoxyphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(2,5-dimethylphenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-2-hexyl-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-hexyl-4-(2-methoxyphenyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo-[4,3-a][1,4]diazepine and 2-hexyl-4-(2-methylphenyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine.
Claim 4
Dependent Claim
65 words
A thienodiazepine compound of the formula: wherein Ar is phenyl, pyridyl substituted phenyl or substituted pyridyl; R 1 is hydrogen or alkyl having 1 to 4 carbon atoms; R is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R 4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
65 words
A thienodiazepine compound of the formula: wherein Ar is phenyl, pyridyl substituted phenyl or substituted pyridyl; R 1 is hydrogen or alkyl having 1 to 4 carbon atoms; R is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R 4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
28 words
A drug for treatment of circulatory diseases comprising a compound of Claim 1, 2 or 3 or a pharmaceutically acceptable acid addition salt thereof as an active ingredient.
Claim 7
Dependent Claim
26 words
A drug of Claim 4 for treatment of circulatory diseases which is a coronary vasodilating agent, a drug for heart failure or a cerebral vasodilating agent.
Claim 8
Dependent Claim
33 words
A drug for treatment of various diseases induced by platelet activating factor comprising a compound of Claim 1, 2 or 3 or a pharmaceutically acceptable acid addition salt thereof as an active ingredient.
References Cited (Backward Citations)
No citation records indexed.
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