Adhesive compositions, controlled release compositions and transdermal drug delivery device

Claim 2

An adhesive composition consisting essentially of a blend of (A) about 10 to 99 wt.% of said composition of a random graft copolymer having the average formula wherein x/y is in the range of 0.01 to 100, inclusive; x+ y is in the range of 10 to 1000, inclusive; z is a number less than or equal to 15; R is a monovalent hydrocarbon radical selected from alkyl groups having 1 to 8 carbon atoms, aryl groups, and haloalkyl groups; all R groups can be the same or different; M is H, -COCH = CH2 or and G is a divalent radical selected from -CH 2 CH 2 CH 2 0-, -CH 2 CH 2 O- and urethane groups; and (B) correspondingly 1 to 90 wt.% of a random resinous copolymer consisting essentially of structural units having the formulae SiO 0.5 and SiO 2 wherein R 3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt.%.

Claim 3

The composition of claim 1 wherein G is a urethane group of the formula -R 1 NR 4 C(O)NHR 2 NHC(O)O-wherein R 1 is a divalent alkylene group, R 2 is selected from alkylene and arylene groups and R4. is H or CH 3 .

Claim 4

The composition of claim 1 in the form of a membrane.

Claim 5

A controlled release composition comprising (1) a composition consisting essentially of a blend of (A) about 10 to 100 wt.% of said composition of a random graft copolymer having the average formula wherein x/y is in the range of 0.01 to 100, inclusive; x + y is in the range of 10 to 1000, inclusive; z is a number less than or equal to 15; R is a monovalent hydrocarbon radical selected from alkyl groups having 1 to 8 carbon atoms, aryl groups, and haloalkyl groups; all R groups can be the same or different; M is H, -COCH = CH 2 or and G is a divalent radical selected from -CH 2 CH 2 CH 2 O-, -CH 2 CH 2 0- and urethane groups; and (B) correspondingly 0 to 90 wt.% of a random resinous copolymer consisting essentially of structural units having the formulae R3 SiO O . 5 and SiO 2 wherein R 3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt.%; and, (2) a bioactive or chemical agent dispersed through said composition.

Claim 6

A controlled release composition comprising (1) a composition consisting essentially of a blend of (A) about 10 to 100 wt.% of said composition of a random graft copolymer having the average formula wherein x/y is in the range of 0.01 to 100, inclusive; x + y is in the range of 10 to 1000, inclusive; z is a number less than or equal to 15; R is a monovalent hydrocarbon radical selected from alkyl groups having 1 to 8 carbon atoms, aryl groups, and haloalkyl groups; all R groups can be the same or different; M is H, -COCH = CH 2 or and G is a divalent radical selected from -CH 2 CH 2 CH 2 O-, -CH 2 CH 2 0- and urethane groups; and (B) correspondingly 0 to 90 wt.% of a random resinous copolymer consisting essentially of structural units having the formulae R3 SiO O . 5 and SiO 2 wherein R 3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt.%; and, (2) a bioactive or chemical agent dispersed through said composition.

Claim 7

The controlled release composition of claim 4 wherein said agent is a drug.

Claim 8

The controlled release composition of claim 5 wherein said drug is a hydrophilic drug.

Claim 9

The controlled release composition of claim 5 wherein said drug is selected from the group consisting of steroids, antihistamines, antihypertensives, antismoking, antianginal and antiinflammatory drugs.

Claim 10

The controlled release composition of claim 7 wherein said drug is selected from the group consisting of progesterone, testosterone, hydrocortisone, β-estradiol, chlorophinaramine, clonidine, nicotine, nitroglycerine and indomethacine.

Claim 11

The controlled release composition of claim 4 wherein said agent is a herbicide or insecticide.

Claim 12

The controlled release composition of claim 4 wherein said agent is atrazine.

Claim 13

The controlled release agent of claim 9 wherein said agent is chlorpyrifos.

Claim 14

The controlled release composition of claim 4 wherein said agent is a pheromone.

Claim 15

The controlled release agent of claim 12 wherein said pheromone is trimedlure.

Claim 16

A transdermal drug delivery device comprising: (a) a backing layer; (b) a layer of said controlled release composition of claim 4 adhered to an interior surface of said backing layer; and (c) a release liner adhered to said controlled release composition layer of (b).

Claim 17

A transdermal drug delivery device comprising: (a) a backing layer; (b) a layer of said controlled release composition of claim 4 adhered to an interior surface of said backing layer; and (c) a release liner adhered to said controlled release composition layer of (b).

Claim 18

In the delivery device of claim 15 wherein said backing layer comprises an air-impermeable material, the improvement comprising: perforations in said air-inpermeable material for permitting the egress of moisture through said backing layer.

Claim 19

In the delivery device of claim 15 wherein the area of said backing layer interior surface is greater than the area of said controlled release composition layer, the improvement comprising: a layer of a pressure sensitive adhesive material covering those portions of the interior surface of said backing layer not covered by said controlled release composition; and said release liner is adapted to cover said backing layer interior surface.