EP0307097A2
Expired / Lapsed
EP
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Water-insolubilized cytokines
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1988-08-17
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Granted: —
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Expires: 2008-08-17
Abstract
Abstract Cytokines are water-insolubilized by acting a physiologically adaptable protein or high molecular organic acid on a cytokine, and thus obtained water-insolubilized cytokines retains physiological activity, and therefore, the water-insolubilized cytokines are useful as sustained release injections.
Inventors
- 👤 Yasushi Mikura
- 👤 Hisayoshi Shimizu
- 👤 Hajime Toguchi
- 👤 Jun Sato
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 09:19
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61K38/20; A61K38/2013; A61K38/217; A61K47/00; A61K47/30; A61K47/36; A61K47/42; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
47 words
A method for producing a physiological activity-retaining and water-insolubilized form of a cytokine, which comprises acting physiologically adaptable protein or a physiologically adaptable high molecular organic acid having a molecular weight of not less than 5,000 or a salt thereof on a cytokine in an aqueous medium.
Claim 2
Independent Claim
47 words
A method for producing a physiological activity-retaining and water-insolubilized form of a cytokine, which comprises acting physiologically adaptable protein or a physiologically adaptable high molecular organic acid having a molecular weight of not less than 5,000 or a salt thereof on a cytokine in an aqueous medium.
Claim 3
Dependent Claim
22 words
A method as claimed in Claim 1, wherein a physiologically adaptable protein is acted on a cytokine in water under physical stimulation.
Claim 4
Dependent Claim
35 words
A method as claimed in Claim 1, wherein a physiologically adaptable high molecular organic acid having a molecular weight of not less than 5000 or a salt thereof is acted on a cytokine in water.
Claim 5
Dependent Claim
25 words
A method as claimed in Claim 1, wherein a physiologically adaptable protein is acted on a cytokine in the coexistence of a water-soluble organic solvent.
Claim 6
Dependent Claim
12 words
A method as claimed in Claim 1, wherein the cytokin is water-soluble.
Claim 7
Dependent Claim
12 words
A method as claimed in Claim 1, wherein the cytokine is lymphokine.
Claim 8
Dependent Claim
12 words
A method as claimed in Claim 6, wherein the lymphokine is interleukin-2.
Claim 9
Dependent Claim
12 words
A method as claimed in Claim 6, wherein the lymphokine is interferon.
Claim 10
Dependent Claim
11 words
A method as claimed in Claim 8, wherein interferon is interferon-α.
Claim 11
Dependent Claim
11 words
A method as claimed in Claim 8, wherein interferon is interferon-γ.
References Cited (Backward Citations)
No citation records indexed.
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