EP0306336A2
Expired / Lapsed
EP
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Multiple port assay device
Assignee: Syntex USA LLC
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Filing: 1988-09-02
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Granted: —
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Expires: 2008-09-02
Abstract
Abstract A device (10) is disclosed for conducting an assay. The device comprises a housing (12), means enclosed in the housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from the zone, first means in the housing for introducing the sample into the device, and second means in the housing other than the first means for introducing a liquid reagent other than the sample into the device. The device of the invention finds use in assay methods for the determination of an analyte in a sample suspected of containing the analyte. Kits for conducting an assay are also disclosed.
Inventors
- 👤 Geoffrey A. Dafforn
- 👤 Martin Becker
- 👤 Nurith Kurn
- 👤 Edwin F. Ullman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 11:02
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54386; G01N33/54387; G01N33/54388; B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5023; G01N33/5302; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10S435/81; Y10S436/00; Y10S436/807; Y10S436/81
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
96 words
A device for conducting an assay for the determination of an analyte in a sample, said device comprising: (a) a housing, (b) means enclosed in said housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from said zone, (c) first means in said housing for introducing the sample into the device, and (d) second means in said housing for introducing liquid reagent other than said sample into the device without also introducing said liquid reagent through said first means.
Claim 2
Independent Claim
96 words
A device for conducting an assay for the determination of an analyte in a sample, said device comprising: (a) a housing, (b) means enclosed in said housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from said zone, (c) first means in said housing for introducing the sample into the device, and (d) second means in said housing for introducing liquid reagent other than said sample into the device without also introducing said liquid reagent through said first means.
Claim 3
Dependent Claim
25 words
The device of Claim 1 wherein the means (b) for capturing comprises a bibulous material that is immunosorbing or is capable of being rendered immunosorbing.
Claim 4
Dependent Claim
31 words
The device of Claim 2 wherein said bibulous material has a member of a specific binding pair (sbp) bound thereto, preferably wherein said sbp member is an antibody or an antigen.
Claim 5
Dependent Claim
24 words
The device of Claim 2 or Claim 3 wherein a second piece of bibulous material is in liquid receiving relationship with said bibulous material.
Claim 6
Independent Claim
37 words
The device of any one of Claims 1 to 4 which further includes one or more self-contained liquid reagents enclosed in said housing for conducting an assay method for the determination of an analyte in a sample.
Claim 7
Dependent Claim
27 words
The device of Claim 5 wherein said liquid reagent or reagents are contained in a water insoluble breakable container and said liquid reagent(s) contain an enzyme substrate.
Claim 8
Independent Claim
25 words
The device of any one of claims 1 to 6 wherein said first means (c) and said second means (d) are openings in said device.
Claim 9
Independent Claim
80 words
A device for conducting an assay comprising an inlet means for introducing a sample containing an analyte into said device and means for transporting liquid away from said inlet means, characterized in that it comprises means other than said inlet means for introducing liquid reagent other than said sample into said device and means for transporting said liquid reagent by capillary action away from said means other than said inlet means, preferably wherein said transporting means is a bibulous material.
Claim 10
Independent Claim
80 words
A device for conducting an assay comprising an inlet means for introducing a sample containing an analyte into said device and means for transporting liquid away from said inlet means, characterized in that it comprises means other than said inlet means for introducing liquid reagent other than said sample into said device and means for transporting said liquid reagent by capillary action away from said means other than said inlet means, preferably wherein said transporting means is a bibulous material.
Claim 11
Independent Claim
104 words
A method for conducting an assay for an analyte suspected of being in a sample, which method comprises: (a) introducing a test solution comprising a sample suspected of containing an analyte into the device of any one of claims 1 to 8 through said first means, (b) allowing said test solution to traverse at least a portion of said zone, (c) introducing a liquid agent into said device through said second means whereby said agent traverses at least a portion of said zone, and (d) observing said zone for the presence of a signal in relation to the presence of analyte in said sample.
Claim 12
Dependent Claim
24 words
A kit for conducting an assay method, said kit comprising in a packaged combination the device of any one of claims 1 to 10.
References Cited (Backward Citations)
No citation records indexed.
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