Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same

Claim 1

An aminoalkoxyphenyl derivative of formula: in which: B represents a -S-, -SO- or -SO₂- group, R₁ and R₂ which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen atom, A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical in which the hydroxy is optionally substituted by a lower alkyl radical, R₃ denotes hydrogen or an alkyl radical in C₁-C₈, R₄ denotes hydrogen or an alkyl radical in C₁-C₈ or R₃ and R₄ when taken together, denote an alkylene or alkenylene radical having from 3 to 6 carbon atoms and optionally substituted with a phenyl radical or optionally interrupted by -O-, -N= or -Ń-R₁₁, R₁₁ denoting hydrogen or a lower alkyl in C₁-C₄, phenyl, diphenylmethyl, benzyl or halogenobenzyl radical, Cy represents a group of formula: R represents a hydrogen, an alkyl radical in C₁-C₈, a cycloalkyl radical in C₃-C₆, a benzyl radical or a phenyl radical optionally substituted with one or more substituents, which may be identical or different, selected from halogen atoms, and from lower alkyl in C₁-C₄, lower alkoxy in C₁-C₄ or nitro groups, R₅ and R₆ are taken together with the carbon atoms to which they are attached to form : - an optionally aromatic mono- or di-cyclic carbocyclic group having from 5 to 10 carbon atoms and optionally substituted by a R group in the α-position with respect to the methyne group, - an optionally aromatic 5-membered heterocyclic group, the hetero­atoms or heterogroups being selected from the groups O, S, N, -Ń-R₁₁; O and N; O and -Ń-R₁₁; S and N; S and -Ń-R₁₁; N and N; N and -Ń-R₁₁, the heterocyclic group being optionally substituted by a R group in the α-position with respect to the methyne group and optionally substituted by one or two groups selected from lower alkyl in C₁-C₄ and phenyl groups, - an optionally aromatic 6- to 10-membered mono- or di-cyclic hetero­cyclic group, the heteroatoms or heterogroups being selected from the groups O, S, N, -Ń-R₁₁; O and N; O and -Ń-R₁₁; S and N; S and -Ń-R₁₁; N and N; N and -Ń-R₁₁, the heterocyclic group being optionally substituted by a R group in the α-position with respect to the methyne group, R₇ and R₈, which are the same or different, each represent hydrogen, a lower alkyl radical in C₁-C₄ or a phenyl radical or when they are taken together with the carbon atoms to which they are attached,re­present an optionally aromatic 6-membered carbocyclic ring, R₉ represents oxygen or sulphur, R₁₀ represents oxygen, sulphur or a group -Ń-R₁₁, R₁₂ and R₁₃, which are identical or different, each represent hydrogen, a lower alkyl radical in C₁-C₄ or a benzoyl radical, with the proviso that Cy does not represent a 1-indolizinyl, benzo[b]­furyl or benzyl[b]thienyl group, as well as the N-oxide derivative thereof and a pharmaceutically acceptable salt thereof.