EP0294186A2
Expired / Lapsed
EP
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Activated medium
Assignee: Pall Corp
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Filing: 1988-06-01
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Granted: —
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Expires: 2008-06-01
Abstract
Abstract A porous chemically activated medium having a low affinity for peptide group-containing materials is provided comprising a porous polymeric medium having a low affinity for peptide group-containing materials covalently bound to a residue of an activating agent which is capable of reacting with an acceptor molecule.
Inventors
- 👤 Thomas Charles Gsell
- 👤 Richard Frank Salinaro
- 👤 Peter John Degen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 09:22
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0093; B01D67/00931; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54393; G01N33/544; G01N33/545; G01N33/68; B01D2323/00; B01D2323/30; B01D2323/38; Y; Y10; Y10S; Y10S436/00; Y10S436/824; Y10S436/825; Y10S436/827; Y10S436/828; Y10S436/901; Y10S436/905; Y10S521/00; Y10S521/901; Y10S521/905
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
53 words
A porous chemically activated medium having a low non-specific affinity for peptide group-containing materials comprising: a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, covalently bound to a residue of an activating agent which is capable of reacting with an acceptor molecule.
Claim 2
Dependent Claim
53 words
A porous chemically activated medium having a low non-specific affinity for peptide group-containing materials comprising: a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, covalently bound to a residue of an activating agent which is capable of reacting with an acceptor molecule.
Claim 3
Dependent Claim
20 words
The chemically activated medium of claim 1 wherein said porous polymeric medium comprises a material rich in pendant hydroxyl groups.
Claim 4
Dependent Claim
45 words
The chemically activated medium of claim 2 wherein the porous polymeric medium comprises: (a) a porous polymeric substrate, and (b) a surface-modifying polymeric material having a low affinity for peptide group-containing materials formed at and covalently bonded to the surface of said porous polymeric substrate.
Claim 5
Dependent Claim
27 words
The chemically activated medium of claim 3 wherein said polymeric substrate comprises a material having C-H bonds capable of forming radicals under the influence of ionizing radiation.
Claim 6
Dependent Claim
25 words
The chemically activated medium of claim 3 wherein said surface-modifying covalently bound polymeric material is formed from a monomer having at least one hydroxyl group.
Claim 7
Dependent Claim
25 words
The chemically activated medium of claim 5 wherein said monomer from which said covalently bound surface-modifying polymeric material is formed comprises an ethylenically unsaturated compound.
Claim 8
Dependent Claim
15 words
The chemically activated medium of claim 3 wherein said porous polymeric substrate comprises a polyamide.
Claim 9
Dependent Claim
13 words
The chemically activated medium of claim 7 wherein said polyamide is nylon 66.
Claim 10
Dependent Claim
16 words
The chemically activated medium of claim 3 wherein said porous polymeric substrate comprises a hydrophilic material.
Claim 11
Dependent Claim
13 words
The chemically activated medium of claim 3 wherein said polymeric substrate is microporous.
Claim 12
Dependent Claim
15 words
The chemically activated medium of claim 1 wherein said peptide group-containing material comprises proteinaceous material.
Claim 13
Dependent Claim
32 words
The chemically activated medium of claim 1 wherein said medium has an adsorption of proteinaceous material measured by the Immersion Protein Binding Assay of no more than 30 micrograms per square centimeter.
Claim 14
Dependent Claim
26 words
The chemically activated medium of claim 5 wherein said monomer from which said surface-modifying covalently bound polymeric material is formed comprises a hydroxyalkyl acrylate of methacrylate.
Claim 15
Dependent Claim
30 words
The chemically activated medium of claim 5 wherein said monomer from which said surface-modifying covalently bound polymeric material is formed is 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, hydroxypropyl acrylate, and hydroxypropyl methacrylate.
Claim 16
Dependent Claim
18 words
The chemically activated medium of claim 5 wherein said monomer is 2-hydroxyprop-1-yl acrylate, 1-hydroxyprop-2-yl acrylate or mixtures thereof.
Claim 17
Dependent Claim
14 words
The chemically activated medium of claim 1 wherein said activating agent comprises a bisazolide.
Claim 18
Dependent Claim
17 words
The chemically activated medium of claim 1 wherein said activating agent comprises a bisazolide of carbonic acid.
Claim 19
Dependent Claim
13 words
The chemically activated medium of claim 1 wherein said activating agent comprises N,N′-carbonyldiimidazole.
Claim 20
Dependent Claim
47 words
The chemically activated medium of claim 3 wherein said porous polymeric substrate comprises nylon 66, the monomer from which said surface-modifying covalently bound polymeric material is formed is hydroxypropyl acrylate and the activating agent of which a residue is bound to the porous polymeric medium is N,N′-carbonyldiimidazole.
Claim 21
Dependent Claim
40 words
The chemically activated medium of claim 2 wherein the porous polymeric medium comprises: (a) a porous polymeric substrate, and (b) a polymer coating having a low affinity for peptide group-containing materials formed at the surface of said porous polymeric substrate.
Claim 22
Dependent Claim
15 words
The chemically activated medium of claim 20 wherein said porous polymeric substrate comprises a polyamide.
Claim 23
Dependent Claim
13 words
The chemically activated medium of claim 21 wherein said polyamide is nylon 66.
Claim 24
Dependent Claim
16 words
The chemically activated medium of claim 20 wherein said porous polymeric substrate comprises a hydrophilic material.
Claim 25
Dependent Claim
35 words
The chemically activated medium of claim 20 wherein said polymeric coating is formed from a polymer having a plurality of hydroxyl groups and a cross-linking agent having functional groups which react with the hydroxyl groups.
Claim 26
Dependent Claim
15 words
The chemically activated medium of claim 24 wherein said cross-linking agent is a polymeric substance.
Claim 27
Dependent Claim
13 words
The chemically activated medium of claim 20 wherein said polymeric substrate is microporous.
Claim 28
Dependent Claim
15 words
The chemically activated medium of claim 24 wherein said hydroxyl group-containing polymer is hydroxypropyl cellulose.
Claim 29
Dependent Claim
20 words
The chemically activated medium of claim 24 wherein said cross-linking agent is a copolymer of acrylic acid and N-methylol acrylamide.
Claim 30
Dependent Claim
13 words
The chemically activated medium of claim 20 wherein said activating agent comprises N,N′-carbonyldiimidazole.
Claim 31
Dependent Claim
50 words
The chemically activated medium of claim 20 wherein said substrate comprises microporous, hydrophilic nylon 66 and said polymer coating is a product formed from the reaction of hydroxypropyl cellulose and a copolymer of acrylic acid and N-methylol acrylamide, and the residue of an activating agent comprises a residue of N,N′-carbonyldiimidazole.
Claim 32
Independent Claim
40 words
A method of producing a chemically activated medium comprising reacting a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, with an activating agent to form a chemically activated medium.
Claim 33
Independent Claim
40 words
A method of producing a chemically activated medium comprising reacting a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, with an activating agent to form a chemically activated medium.
Claim 34
Dependent Claim
55 words
The method of producing a chemically activated medium of claim 31 wherein said porous polymeric medium comprises a material rich in pendant hydroxyl groups including: a porous polymeric substrate, and a surface-modifying polymeric material having a low affinity for peptide group-containing materials formed at and covalently bonded to the surface of said porous polymeric substrate.
Claim 35
Dependent Claim
32 words
The method of producing a porous chemically activated medium of claim 32 wherein said polymeric substrate comprises a material having C-H bonds capable of forming radicals under the influence of ionizing radiation.
Claim 36
Dependent Claim
21 words
The method of producing a porous chemically activated medium according to claim 32 wherein said porous polymeric substrate comprises a polyamide.
Claim 37
Dependent Claim
19 words
The method of producing a porous chemically activated medium according to claim 32 wherein said polyamide is nylon 66.
Claim 38
Dependent Claim
20 words
The method of producing a porous chemically activated medium of claim 32 wherein said monomer comprises an ethylenically unsaturated compound.
Claim 39
Dependent Claim
23 words
The method of producing a porous chemically activated medium of claim 32 wherein said polymeric substrate and said chemically activated medium are microporous.
Claim 40
Dependent Claim
53 words
A porous biologically active medium having a low non-specific affinity for peptide group-containing materials comprising a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, and an acceptor molecule covalently bound to the porous polymeric medium through a residue of an activating agent.
Claim 41
Dependent Claim
53 words
A porous biologically active medium having a low non-specific affinity for peptide group-containing materials comprising a porous polymeric medium having a low affinity for peptide group-containing materials, as measured by the Immersion Protein Binding Assay, and an acceptor molecule covalently bound to the porous polymeric medium through a residue of an activating agent.
Claim 42
Dependent Claim
20 words
The biologically active medium of claim 38 wherein said porous polymeric medium comprises a material rich in pendant hydroxyl groups.
Claim 43
Dependent Claim
43 words
The biologically active medium of claim 38 wherein the porous polymeric medium comprises: a porous polymeric substrate, and a surface-modifying polymeric material having a low affinity for peptide group-containing materials formed at and covalently bonded to the surface of said porous polymeric substrate.
References Cited (Backward Citations)
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