EP0285302A1
Expired / Lapsed
EP
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Sesquiterpenoid isocyanide composition and its methods of use
Assignee: Harbor Branch Oceanographic Institute Foundation Inc
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Filing: 1988-03-22
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Granted: —
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Expires: 2008-03-22
Abstract
Abstract This invention relates to a novel composition which is useful as an antitumor, antiviral and antifungal composition, a process of producing the composition and a method for inhibiting tumors, viruses, and fungi utilizing the composition. More particularly, the novel composition is an organic sesquiterpenoid isocyanide composition which is derived from marine sponge Bubaris sp., and has the general formula:
Inventors
- 👤 Amy E. Wright
- 👤 Peter. Mccarthy
- 👤 Sue Shipley Cross
- 👤 James B. Rake
- 👤 Oliver J. Mcconnell
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 10:45
CPC Classifications
C; C07; C07C; C07C403/00; C07C403/02; A; A61; A61P; A61P31/00; A61P31/04; A61P31/12; A61P35/00; C07C2601/00; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
6 words
A composition according to the formula:
Claim 2
Dependent Claim
6 words
A composition according to the formula:
Claim 3
Dependent Claim
11 words
A composition according to claim 1, the composition being substantially pure.
Claim 4
Dependent Claim
30 words
An antitumor, antiviral or antifungal composition comprising, as active ingredient, an effective antitumor amount of the composition of claim 1 or 2 and a non-toxic pharmaceutically acceptable carrier or diluent.
Claim 5
Dependent Claim
53 words
A process to produce a composition according to claim 1 or 2 comprising: collecting marine sponge genus Bubaris , sp.; contacting the sponge with a suitable organic solvent system; obtaining a solvent extract from the sponge; fractionating the extract; and isolating a composition according to claim 1 or 2 from the fractionated extract.
Claim 6
Dependent Claim
35 words
A process according to claim 4 in which the solvent system is ethyl acetate, heptane, hexanes, isooctane, acetone, methanol, ethanol, isopropanol, toluene, benzene, diethyl ether, t-butyl, methyl ether, chloroform, 1,2-dichloroethane, dichloromethane or any combination thereof.
Claim 7
Dependent Claim
40 words
Process according to claim 4 or 5 in which the solvent extract is fractionated and isolated by vacuum liquid chromatography using an eluent consisting of heptane, hexanes, isooctane, chloroform, dichloromethane, 1,2-dichloroethane, benzene, toluene, isopropanol, diethyl ether, methanol or combinations thereof.
Claim 8
Independent Claim
31 words
A method for inhibiting tumors, viruses or fungus growth comprising contacting a tumor, viruses or fungus with an effective antifungal amount of the composition of any of claims 1 to 3.
Claim 9
Dependent Claim
16 words
A method according to claim 7 of inhibiting tumors, viruses or fungus growth in a host.
Claim 10
Dependent Claim
17 words
A method according to claim 8 for inhibiting tumors, viruses or fungus growth in a mammalian host.
Claim 11
Dependent Claim
38 words
A therapeutic method for treating cancerous cachexia caused by the presence of a tumor in a host comprising contacting cells of said tumor with an effective antitumor amount of a composition according to claim 1, 2 or 3.
References Cited (Backward Citations)
No citation records indexed.
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