EP0285284A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
Assignee: Pfizer Ltd
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Filing: 1988-03-16
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Granted: —
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Expires: 2008-03-16
Abstract
Abstract Compounds of the formula: and their pharmaceutically acceptable salts, wherein R¹ and R⁵ are each independently C₁-C₄ alkyl; R² and R³ are each independently H or C₁-C₄ alkyl; R⁴ is H or C₁-C₄ alkoxy, and n is 2, 3 or 4, are anti-arrhythmia agents useful for the treatment of cardiac conditions.
Inventors
- 👤 Peter Edward Dr. Cross
- 👤 John Edmund Dr. Arrowsmith
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 21:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61P; A61P9/00; A61P9/06; C; C07; C07C; C07C233/00; C07C233/01; C07C233/12; C07C311/00; C07C311/01; C07C311/02
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
87 words
A process for preparing a compound having the formula:- or a pharmaceutically acceptable salt thereof, wherein R¹ and R⁵ are each independently C₁-C₄ alkyl, R² and R³ are each independently H or C₁-C₄ alkyl; R⁴ is H or C₁-C₄ alkoxy, and n is 2, 3 or 4, which comprises reacting a compound of the formula: wherein R², R³, R⁴ and n are as previously defined and R⁸ is NH₂ or (C₁-C₄ alkyl)SO₂NH; with a C₁-C₄ alkyl sulphonylchloride or bromide, or a sulphonic anhydride of formula [(C₁-C₄ alkyl)SO₂]₂O.
Claim 2
Dependent Claim
87 words
A process for preparing a compound having the formula:- or a pharmaceutically acceptable salt thereof, wherein R¹ and R⁵ are each independently C₁-C₄ alkyl, R² and R³ are each independently H or C₁-C₄ alkyl; R⁴ is H or C₁-C₄ alkoxy, and n is 2, 3 or 4, which comprises reacting a compound of the formula: wherein R², R³, R⁴ and n are as previously defined and R⁸ is NH₂ or (C₁-C₄ alkyl)SO₂NH; with a C₁-C₄ alkyl sulphonylchloride or bromide, or a sulphonic anhydride of formula [(C₁-C₄ alkyl)SO₂]₂O.
Claim 3
Dependent Claim
14 words
A process as claimed in claim 1 wherein R¹ and R⁵ are both CH₃.
Claim 4
Dependent Claim
20 words
A process as claimed in claim 1 or claim 2 wherein R² is CH₃ or CH₂CH₃ and R³ is H.
Claim 5
Dependent Claim
18 words
A process as claimed in any one of claims 1 to 3 wherein R⁴ is H or OCH₃.
Claim 6
Dependent Claim
16 words
A process as claimed in any one of claims 1 to 4 wherein n is 2.
Claim 7
Dependent Claim
62 words
A process as claimed in claim 1 which comprises reacting N-[2-(Nʹ-4-methanesulphonamidophenethyl-Nʹ-methyl-amino)ethyl]-4-amino-2-methoxybenzamide with methanesulphonyl chloride to give the compound of formula (I) wherein R¹ is CH₃, R² is CH₃, R³ is H, R⁴ is CH₃O attached at the 2-position of the phenyl ring and R⁵ is CH₃, the group -NHSO₂R⁵ being attached at the 4-position of the phenyl ring, and n is 2.
Claim 8
Dependent Claim
34 words
A process for preparing a pharmaceutical composition characterised by mixing a compound of the formula (I) as defined in claim 1, or a pharmaceutically acceptable salt thereof, with a pharmaceutically acceptable diluent or carrier.
References Cited (Backward Citations)
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