← Back to Patent Explorer
EP0281204A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Method of protecting scarcely stable substances with polymeric mixture and application thereof

Assignee: Dott Bonapace & C SpA
•
Filing: 1988-03-01
•
Granted: —
•
Expires: 2008-03-01
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract The invention relates to methods for the application of a protective film to all types of powders in order to make them more inert to chemical and physical attack. This film is obtained with polymers containing various percentages of Si and with procedures conducted with and without electrical fields in which the operations of granulation and covering the powders and granules are conducted simultaneously. The product is obtained by atomisation of a suspension of the powder in a suitable organic solvent, in which the polymer can be dissolved, obtained with a rotating disk of a suitable material with good electrical conductivity. The resulting product has a different density and greater fluidity and, above all, greater stability than the starting material. Film-forming technologies also permit the design of simpler forms of delayed-dissolution pharmaceuticals and/or masking of the taste. The processes described are suitable for use on production lines of particularly labile products thus reducing to a minimum the difficulties involved in treating them.

Inventors

  • 👤 Paolo Gronchi
  • 👤 Roberto Francesco Cosentino

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-25 10:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1682; A61K9/1694; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; A61K9/5089

Claims Analysis

Total Claims: 16
Claim 1
Independent Claim 79 words
Method for covering substances with limited stability with a protective film characterised by the fact that the protective film is constituted by a mixture of polymers of the type where R=R, = alkyl or aryl, or R=alkyl or aryl and R, = a radical of an organic molecule containing O,N,S and where n is an integer, and polymers of type (I) can be used either alone or mixed with other polymers, synthesised or natural or with plasticisers and additives.
Claim 2
Dependent Claim 79 words
Method for covering substances with limited stability with a protective film characterised by the fact that the protective film is constituted by a mixture of polymers of the type where R=R, = alkyl or aryl, or R=alkyl or aryl and R, = a radical of an organic molecule containing O,N,S and where n is an integer, and polymers of type (I) can be used either alone or mixed with other polymers, synthesised or natural or with plasticisers and additives.
Claim 3
Dependent Claim 74 words
Covering and granulation, microgranulation and/or microencapsulation method according to claim 1, in which the substance to be covered is kept in suspension in solvents, either pure or in a mixture, in which the film-forming substance has been dissolved and the solution is maintained in agitation by means of a suitable system and continuously fed to a rotating disk atomiser, or a pressure atomiser or a two-fluid atomiser with or without electric field generating equipment.
Claim 4
Dependent Claim 27 words
Method according to one or more of the preceding claims characterised by the fact that type (I) polymers are constituted by dimethyl poly siloxane and/or diethyl siloxane.
Claim 5
Dependent Claim 18 words
Method according to claims 1 to 3, in which the substances to be covered is menadione sodium bisulphite.
Claim 6
Dependent Claim 17 words
Method according to claims 1 to 4, in which the substance to be covered is ascorbic acid.
Claim 7
Dependent Claim 16 words
Method according to claims 1 to 4, in which the substance to be covered is nicotinamide.
Claim 8
Dependent Claim 28 words
Covering and granulation, microgranulation and/or microencapsulation method according to claims 1 and 2, in which rotating disk atomisation is carried out in order to stabilise the powdered substance.
Claim 9
Dependent Claim 28 words
Covering and granulation, microgranulation and/or microencapsulation method according to claims 1 and 2, in which rotating disk atomisation is carried out to obtain pharmaceutical forms and delayed dissolution.
Claim 10
Dependent Claim 28 words
Covering and granulation, microgranulation and/or microencapsulation method according to claims 1 and 2, in which rotating disk atomisation is carried out to obtain masking of tastes and smells.
Claim 11
Dependent Claim 32 words
Covering and granulation, microgranulation and/or microencapsulation method according to claims 8, 9 or 10 in which an electrical field is applied to the rotating disk to obtain atomisation and the effects indicated.
Claim 12
Dependent Claim 29 words
Protective membrane constituted by wax, fats or other products dissolved in organic or aqueous solutions when these are electrostatically sprayed to obtain protective films on fine powders or liquids.
Claim 13
Dependent Claim 29 words
Protective membrane constituted by wax, fats or other products dissolved in organic or aqueous solutions when these are electrostatically sprayed to obtain protective films on fine powders or liquids.
Claim 14
Dependent Claim 33 words
Substances covered with protective films by means of atomisation, with or without the application of an electrical field, obtained each time by a method according to one or more of the preceding claims.
Claim 15
Dependent Claim 17 words
Process for the protection of substances with limited stability here above and illustrated in the attached examples.
Claim 16
Dependent Claim 17 words
Process for the protection of substances with limited stability here above and illustrated in the attached examples.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Maintenance schedule is calculated for granted US utility patents.

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag