EP0279982A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Transdermal contraceptive formulations
Assignee: Alza Corp
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Filing: 1987-11-05
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Granted: —
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Expires: 2007-11-05
Abstract
Abstract A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.
Inventors
- 👤 Diane E. Nedberge
- 👤 Patricia S. Campbell
- 👤 Robert M. Gale
- 👤 Su Il Yum
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 22:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K31/00; A61K31/56; A61K31/565; A61K31/567; A61K9/7076; A61K9/7084; Y; Y10; Y10S; Y10S424/00; Y10S424/14
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
57 words
A medical device for the transdermal administration of a drug formulation of ethinyl estradiol and levonorgestrel, and a skin permeation enhancer, for an extended period of time, comprising in combination: reservoir means containing said drug formulation and said permeation enhancer; and means for maintaining said reservoir in drug formulation and permeation enhancer transferring relationship to the skin.
Claim 2
Dependent Claim
57 words
A medical device for the transdermal administration of a drug formulation of ethinyl estradiol and levonorgestrel, and a skin permeation enhancer, for an extended period of time, comprising in combination: reservoir means containing said drug formulation and said permeation enhancer; and means for maintaining said reservoir in drug formulation and permeation enhancer transferring relationship to the skin.
Claim 3
Dependent Claim
25 words
A device as claimed in claim 1 wherein said reservoir means is a single reservoir comprised of ethinyl estradiol, levonorgestrel and a skin permeation enhancer.
Claim 4
Dependent Claim
38 words
A device as claimed in claim 1 wherein said reservoir means is a dual reservoir system wherein a first reservoir is comprised of ethinyl estradiol and levonorgestrel and a second reservoir is comprised of a skin permeation enhancer.
Claim 5
Dependent Claim
17 words
A device as claimed in claim 2 or claim 3 wherein said permeation enhancer is glycerol monolaurate.
Claim 6
Independent Claim
48 words
A device as claimed in any preceding claim wherein ethinyl estradiol and levonorgestrel are present in said reservoir means in amounts in excess of their saturation concentrations, in amounts sufficient to maintain the concentration of ethinyl estradiol and levonorgestrel at least at the saturation level throughout said period.
Claim 7
Independent Claim
27 words
A device as claimed in any one of claims 2 to 5 further comprising a means for controlling the release of permeation enhancer from said second reservoir.
Claim 8
Independent Claim
43 words
A device as claimed in any preceding claim wherein said reservoir means contains ethinyl estradiol in an amount sufficient to provide delivery through the skin at a rate of at least 15 µg/day for an extended period of time, up to 7 days.
Claim 9
Independent Claim
46 words
A device as claimed in any one of claims 1 to 6 wherein said reservoir means contains levonorgestrel in an amount sufficient to provide delivery through the skin at a rate of at least 50 µg/day for an extended period of time, up to 7 days.
Claim 10
Independent Claim
21 words
A device as claimed in any preceding claim wherein said extended period of time is the effective life of said device.
Claim 11
Dependent Claim
14 words
A device of claim 10 wherein said effective life is up to 7 days.
References Cited (Backward Citations)
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