Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
227 words
A compound of the formula: wherein R₁ is (1) hydrogen, (2) C₁ to C₄ alkyl, (3) C₂ to C₄ alkenyl, or (4) NR₂R₃, wherein R₂ and R₃ are independently selected from (1) hydrogen, (2) C₁ to C₄ alkyl and (3) hydroxyl, but R₂ and R₃ are not simultaneously hydroxyl; wherein X is oxygen, sulfur, SO₂, or NR₄, wherein R₄ is (1) hydrogen, (2) C₁ to C₆ alkyl, (3) C₁ to C₆ alkoyl, (4) aroyl, or (5) alkylsulfonyl; A is selected from C₁ to C₆ alkylene and C₂ to C₆ alkenylene; n is 1-5; Y is selected independently at each occurrence from (1) hydrogen, (2) halogen, (3) hydroxy, (4) cyano, (5) halosubstituted alkyl, (6) C₁ to C₁₂ alkyl, (7) C₂ to C₁₂ alkenyl, (8) C₁ to C₁₂ alkoxy, (9) C₃ to C₈ cycloalkyl, (10) C₁-C₈ thioalkyl, (11) aryl, (12) aryloxy, (13) aroyl, (14) C₁ to C₁₂ arylalkyl, (15) C₂ to C₁₂ arylalkenyl, (16) C₁ to C₁₂ arylalkoxy, (17) C₁ to C₁₂ arylthioalkoxy, and substituted derivatives of (18) aryl, (19) aryloxy, (20) aroyl, (21) C₁ to C₁₂ arylalkyl, (22) C₂ to C₁₂ arylalkenyl, (23) C₁ to C₁₂ arylalkoxy, or (24) C₁ to C₁₂ arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C₁ to C₁₂ alkyl, alkoxy, and halosubstituted alkyl; Z is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C₁ to C₁₂ alkoyl.
Claim 2
Dependent Claim
227 words
A compound of the formula: wherein R₁ is (1) hydrogen, (2) C₁ to C₄ alkyl, (3) C₂ to C₄ alkenyl, or (4) NR₂R₃, wherein R₂ and R₃ are independently selected from (1) hydrogen, (2) C₁ to C₄ alkyl and (3) hydroxyl, but R₂ and R₃ are not simultaneously hydroxyl; wherein X is oxygen, sulfur, SO₂, or NR₄, wherein R₄ is (1) hydrogen, (2) C₁ to C₆ alkyl, (3) C₁ to C₆ alkoyl, (4) aroyl, or (5) alkylsulfonyl; A is selected from C₁ to C₆ alkylene and C₂ to C₆ alkenylene; n is 1-5; Y is selected independently at each occurrence from (1) hydrogen, (2) halogen, (3) hydroxy, (4) cyano, (5) halosubstituted alkyl, (6) C₁ to C₁₂ alkyl, (7) C₂ to C₁₂ alkenyl, (8) C₁ to C₁₂ alkoxy, (9) C₃ to C₈ cycloalkyl, (10) C₁-C₈ thioalkyl, (11) aryl, (12) aryloxy, (13) aroyl, (14) C₁ to C₁₂ arylalkyl, (15) C₂ to C₁₂ arylalkenyl, (16) C₁ to C₁₂ arylalkoxy, (17) C₁ to C₁₂ arylthioalkoxy, and substituted derivatives of (18) aryl, (19) aryloxy, (20) aroyl, (21) C₁ to C₁₂ arylalkyl, (22) C₂ to C₁₂ arylalkenyl, (23) C₁ to C₁₂ arylalkoxy, or (24) C₁ to C₁₂ arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C₁ to C₁₂ alkyl, alkoxy, and halosubstituted alkyl; Z is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C₁ to C₁₂ alkoyl.
Claim 3
Dependent Claim
55 words
A compound of claim 1 having the formula: wherein R₅ is C₁ or C₂ alkyl, or NR₆R₇ where R₆ and R₇ are independently selected from hydrogen and C₁ or C₂ alkyl; B is CH₂ or CHCH₃; W is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C₁ to C₁₂ alkoyl.
Claim 4
Dependent Claim
8 words
The compound of claim 1 having the formula:
Claim 5
Dependent Claim
8 words
The compound of claim 1 having the formula:
Claim 6
Dependent Claim
26 words
Use of a compound of claim 1 for preparing a drug useful for inhibiting 5- and/or 12-lipoxygenase activity in a mammal in need of such treatment.
Claim 7
Dependent Claim
57 words
Use of claim 5 wherein the compound has the formula: wherein R₅ is C₁ or C₂ alkyl, or NR₆R₇ where R₆ and R₇ are independently selected from hydrogen and C₁ or C₂ alkyl; B is CH₂ or CHCH₃; W is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C₁ to C₁₂ alkoyl.
Claim 8
Dependent Claim
10 words
Use of claim 5 wherein the compound has the formula
Claim 9
Dependent Claim
10 words
Use of claim 5 wherein the compound has the formula:
Claim 10
Dependent Claim
40 words
Use of a compound of claim 1 for preparing a drug useful for treating asthma, rheumatoid arthritis, gout, psoriasis, allergic rhinitis, adult respiratory distress syndrome, Crohn's disease, endotoxin shock, inflammatory bowel disease and/or ischemia induced myocardial or brain injury .
Claim 11
Dependent Claim
23 words
A pharmaceutical composition for inhibiting 5- and/or 12-lipoxygenase, comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of claim 1.