EP0278541A1
Expired / Lapsed
EP
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Antigenically active proteins and peptides, and transmissible gastro-enteritis virus TGEV vaccines
Assignee: Duphar International Research BV
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Filing: 1988-01-14
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Granted: —
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Expires: 2008-01-14
Abstract
Abstract The invention relates to new antigenic proteins which can be used to stimulate the immunity of pigs against transmissible gastro-enteritis virus (TGEV)-vaccines, and to fragments or derivatives thereof. The invention also relates to vaccines which comprise such antigenic proteins or peptides. The nucleotide sequence and amine acid sequence of a gene coding for protein of an TGEV-strain are indicated in figure 1.
Inventors
- 👤 Catharina E. Jacobs
- 👤 Wilhelmus J. M. Spaan
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 15:23
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; A61K39/12; A61K39/215; A61K39/225; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/20011; C12N2770/20022; C12N2770/20034
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
21 words
A gene which codes for protein of transmissible gastro-enteritis virus (TGEV), characterized by the nucelotide sequence as shown in Figure 1.
Claim 2
Dependent Claim
21 words
A gene which codes for protein of transmissible gastro-enteritis virus (TGEV), characterized by the nucelotide sequence as shown in Figure 1.
Claim 3
Dependent Claim
17 words
A protein, characterized by the amino acid sequence as shown in Figure 1, or a part thereof.
Claim 4
Dependent Claim
17 words
A protein, characterized by the amino acid sequence as shown in Figure 1, or a part thereof.
Claim 5
Dependent Claim
23 words
An immunogen, characterized in that it comprises a protein or peptide as claimed in Claim 2, whether or nor coupled to a carrier.
Claim 6
Dependent Claim
14 words
A vaccine, characterized in that it comprises an immunogen as claimed in Claim 3.
Claim 7
Dependent Claim
74 words
A method of preparing a protein or peptide as claimed in Claim 2, characterized in that a) the protein or peptide is synthesised in a manner known per su from individual amino acids and/or by coupling smaller peptides; or b) a host cell is transformed with an expression vector which comprises a DNA coding for a protein or peptide as claimed in Claim 2, and the genome introduced in the expression vector is expressed.
Claim 8
Dependent Claim
37 words
A DNA molecule which comprises a nucleotide sequence which codes for a protein or peptide as claimed in Claim 2, or which codes for a polypeptide which comprises a protein or peptide as claimed in Claim 2.
Claim 9
Dependent Claim
59 words
A recombinant DNA expression vector which expresses the whole protein or peptide or a part thereof as defined in Claim 2, comprising an operon with initiator sequences and terminator sequence and a nucleotide sequence which codes for the said protein or peptide, the said nucleotide sequence being situated between the initiator sequence and the terminator sequence of the operon.
Claim 10
Dependent Claim
20 words
A host cell which comprises a recombinant DNA expression vector and/or DNA molecule as claimed in Claim 6 or 7.
Claim 11
Dependent Claim
59 words
A method of preparing a DNA molecule which codes for a protein or peptide as claimed in Claim 2, characterized in that a) single-stranded TGEV-RNA is isolated; b) a cDNA strand complementary to said RNA strand is synthesised; c) the RNA strand is removed and a second strand of cDNA is synthesised with the first cDNA as a template.
References Cited (Backward Citations)
US4335105A
Cited
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