EP0270926A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Agents promoting the activity of some antitumor agents and methods for their production
Assignee: Japanese Foundation for Cancer Research
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Filing: 1987-11-25
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Granted: —
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Expires: 2007-11-25
Abstract
Abstract This invention relates to new and useful 2,6-dimethyl-4-(pyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3.5-dicarboxylate derivatives of the following formula; and pharmaceutically acceptable salts thereof having the potent promoting activity of some antitumor agents against various kinds of tumor cells including multiple drug resistant tumor cells.
Inventors
- 👤 Makoto / C/O Jap. Found. Cancer Research Inaba
- 👤 Hirotaka Shinoda
- 👤 Fujio Iinuma
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 05:04
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
88 words
2,6-dimethyl-4-(pyrazolo[1,5-a]pyridin-3-yl)-1,4- dihydropyridine-3,5-dicarboxylate derivatives of formula (I) wherein R and R 3 are each independently alkyl, lower alkoxyalkyl, aralkyl group, or -A-v(A is straight or branched 5 alkylene group, and R 4 and R 5 are each independently a hydrogen atom, lower alkyl, aralkyl group, or connected with each other to make five- or six-membered heterocycles which may contain other hetero atom), R 2 is a hydrogen atom, halogen atom, lower alkyl, lower alkoxy, or nitro group, and R 1 is lower alkyl group,and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
88 words
2,6-dimethyl-4-(pyrazolo[1,5-a]pyridin-3-yl)-1,4- dihydropyridine-3,5-dicarboxylate derivatives of formula (I) wherein R and R 3 are each independently alkyl, lower alkoxyalkyl, aralkyl group, or -A-v(A is straight or branched 5 alkylene group, and R 4 and R 5 are each independently a hydrogen atom, lower alkyl, aralkyl group, or connected with each other to make five- or six-membered heterocycles which may contain other hetero atom), R 2 is a hydrogen atom, halogen atom, lower alkyl, lower alkoxy, or nitro group, and R 1 is lower alkyl group,and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
41 words
A process for the preparation of novel 2,6-dimethyl-4-(pyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate derivatives of formula (I) wherein R, R 1 , R 2 , and R 3 have the meaning specified in claim 1, which comprises reacting by heating 2-acetyl-3-(pyrazolo[1,5-a] pyridin-3-yl)acrylate derivatives of formula (V)
References Cited (Backward Citations)
No citation records indexed.
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