EP0269447A2
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EP
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Structures surface modified with bidentate silanes
Assignee: Agilent Technologies Inc
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Filing: 1987-11-26
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Granted: —
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Expires: 2007-11-26
Abstract
Abstract A functionalized support comprising a substrate having a modified surface, characterised in that the substrate surface is modified with a bidentate silane containing at least two silicon atoms bridged by groups so arranged that an at least seven-membered ring system is formed of the following formula: wherein each of R₁ to R₄, which may be the same or different, represent alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl; Y represents -O-, -CH₂-, -CH₂CH₂-, -(CH₂) n , -(CHZ-CHZ)- or -(CH₂) n CHZ-, where Z represents alkane, substituted alkane, alkene, substituted alkene, aryl, substituted aryl, halogen, hydroxyl, hydrogen, nitrile, primary, secondary or tertiary or tetralkylamine, carbonyl, carboxyl, amide, sulfonic acid, nitro, nitroso, amide or sulfonamide, and n is 1 to 6; and A represents the atoms on the substrate surface to which the silane is covalently attached, subject to the proviso that when Y is -O- R₁ to R₄ do not all represent methyl finds use in, for example, chromatographic separations.
Inventors
- 👤 Joseph Louis Glajch
- 👤 Joseph Jack Kirkland
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 05:31
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3259; B01J20/3261; G; G01; G01N; G01N30/00; G01N30/02; G01N30/50; G01N30/56; G01N2030/567; G01N30/88; G01N2030/8809; G01N2030/8813; G01N2030/8831; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2993; Y10T428/2995; Y10T428/2996; Y10T428/2998; Y10T428/31504; Y10T428/31652; Y10T428/31663
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
154 words
A functionalized support comprising a substrate having a modified surface, characterised in that the substrate surface is modified with a bidentate silane containing at least two silicon atoms bridged by groups so arranged that an at least seven-membered ring system is formed of the following formula: wherein each of R₁ to R₄, which may be the same or different, represent alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl; Y represents -O-, -CH₂-, -CH₂CH₂-, (CH₂) n , -(CHZ-CHZ), or -(CH₂) n CHZ-, where Z represents alkane, substituted alkane, alkene, substituted alkene, aryl, substituted aryl, halogen, hydroxyl, hydrogen, nitrile, primary, secondary or tertiary or tetralkylamine, carbonyl, carboxyl, amide, sulfonic acid, nitro, nitroso, amide or sulfonamide, and n is 1 to 6; and A represents the atoms on the substrate surface to which the silane is covalently attached, subject to the proviso that when Y is -O- R₁ to R₄ do not all represent methyl.
Claim 2
Dependent Claim
154 words
A functionalized support comprising a substrate having a modified surface, characterised in that the substrate surface is modified with a bidentate silane containing at least two silicon atoms bridged by groups so arranged that an at least seven-membered ring system is formed of the following formula: wherein each of R₁ to R₄, which may be the same or different, represent alkane, substituted alkane, alkene, substituted alkene, aryl or substituted aryl; Y represents -O-, -CH₂-, -CH₂CH₂-, (CH₂) n , -(CHZ-CHZ), or -(CH₂) n CHZ-, where Z represents alkane, substituted alkane, alkene, substituted alkene, aryl, substituted aryl, halogen, hydroxyl, hydrogen, nitrile, primary, secondary or tertiary or tetralkylamine, carbonyl, carboxyl, amide, sulfonic acid, nitro, nitroso, amide or sulfonamide, and n is 1 to 6; and A represents the atoms on the substrate surface to which the silane is covalently attached, subject to the proviso that when Y is -O- R₁ to R₄ do not all represent methyl.
Claim 3
Dependent Claim
21 words
A support according to claim 1 wherein substantially all of the silane is bonded to the substrate through both Si atoms.
Claim 4
Dependent Claim
32 words
A support according to claim 1 or 2 wherein the substrate is a metal oxide, metalloid oxide or organic polymer or plastic having a surface capable of reacting with bidentate silane reagents.
Claim 5
Dependent Claim
15 words
A support according to claim 2 wherein the substrate is silica and Y is -O-.
Claim 6
Dependent Claim
14 words
A support according to claim 1, 2 or 3 wherein the substrate is silica.
Claim 7
Dependent Claim
13 words
A support according to claim 4 or 5 wherein the silica is porous.
Claim 8
Dependent Claim
36 words
A support according to any one of the preceding claims wherein Y is -O-, -CH₂CH₂-, CH(-CH=CH₂)-CH(-CH=CH₂)-, -CH[(CH₂)₃NH₂]-CH[(CH₂)₃NH₂]-, -CH[(CH₂)₃CN]-CH[(CH₂)₃CN]-, -CH(C₁₈)-CH(C₁₈)- -CH-[(CH₂)₃-O-CH(OH)CH₂-OH[CH[(CH₂)₃-O-CH(OH)CH₂-OH]- or -CH(C₈)-CH(C₈), wherein C₈ and C₁₈ are n-hydrocarbon groups of 8 and 18 carbon atoms respectively.
Claim 9
Dependent Claim
23 words
A support according to any one of the preceding claims wherein the R₁-R₄ groups provide steric protection of the bonded silane from hydrolysis.
Claim 10
Dependent Claim
17 words
A support according to claim 8 wherein R₁-R₄ are isopropyl, secondary butyl, isobutyl, t-butyl, neopentyl or cyclohexyl.
Claim 11
Dependent Claim
49 words
A support according to claim 1 comprising a silica substrate and bidentate silane attached to the substrate, the bidentate silane containing at least two silicon atoms bridged by groups so arranged that an at least seven-membered ring system is formed of the structure: wherein Y is -O- or -CH₂CH₂-.
Claim 12
Dependent Claim
55 words
A process for making a support as claimed in any one of the preceding claims which comprises reacting a bidentate silane reagent of the formula: wherein R₁ to R₄ and Y are as defined in claim 1 and X represents a reactive group with a substrate which contains surface groups reactive with the X groups.
Claim 13
Dependent Claim
17 words
A process according to claim 11 or 12 wherein the reactive surface groups include -OH and/or -Cl.
Claim 14
Dependent Claim
23 words
A process according to claim 11 or 12 wherein the reactive surface groups have been established by hydroxylating the surface of the substrate.
Claim 15
Dependent Claim
19 words
A process according to claim 11, 12 or 13 wherein the silicon atoms of the bidentate silane are monofunctional.
Claim 16
Dependent Claim
38 words
A process according to any one of claims 11 to 14 wherein Y is selected to provide a spacing between the two reactable atoms of the bidentate silane comparable to that of the attachment points on the substrate.
Claim 17
Dependent Claim
18 words
Use of a support as claimed in any one of claims 1 to 10 in a chromatographic separation.
References Cited (Backward Citations)
No citation records indexed.
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