EP0268707A2
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EP
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Negatively charged specific affinity reagents
Assignee: USSR Cardiology Research Centre
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Filing: 1986-11-05
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Granted: —
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Expires: 2006-11-05
Abstract
Abstract An in vivo imaging or therapeutic method including administering to a mammal a specific affinity reagent including a physiologically compatible polymer bonded to one or more specific affinity molecules capable of selectively binding to a predetermined substance or class of cells, and one or more reporter groups capable of providing detectable contrast between the predetermined substance or class of cells and cells or substances of the mammal to which the specific affinity reagent does not bind, or of killing cells of the predetermined class.
Inventors
- 👤 Ban An Khaw
- 👤 Vladimir P. Torchilin
- 👤 Alexander L.§ul. Arkhitektora Valsova Klibanov
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 13:40
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/645; A61K47/68; A61K47/6835; A61K47/6887; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1093; A61P; A61P35/00; A61K2121/00; A61K2123/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
91 words
The use of a specific affinity reagent comprising a physiologically compatible polymer bonded to one or more specific affinity molecules capable of selectively binding to a predetermined substance or class of cells, and one or more reporter groups capable of providing detectable contrast between said predetermined substance or class of cells and cells or substances of said mammal to which said specific affinity reagent does not bind, or of killing cells of said predetermined class, in the preparation of an agent for use in an in vivo imaging or therapeutic method.
Claim 2
Dependent Claim
91 words
The use of a specific affinity reagent comprising a physiologically compatible polymer bonded to one or more specific affinity molecules capable of selectively binding to a predetermined substance or class of cells, and one or more reporter groups capable of providing detectable contrast between said predetermined substance or class of cells and cells or substances of said mammal to which said specific affinity reagent does not bind, or of killing cells of said predetermined class, in the preparation of an agent for use in an in vivo imaging or therapeutic method.
Claim 3
Dependent Claim
18 words
The use as claimed in claim 1 wherein said specific affinity reagent is negatively charged under physiological conditions.
Claim 4
Dependent Claim
48 words
A specific affinity reagent comprising a physiologically compatible polymer containing a plurality of negatively charged groups, a specific affinity compound having specific affinity for a target substance or cells, said specific affinity compound being bonded to said polymer, and at least one reporter group bonded to said polymer.
Claim 5
Dependent Claim
48 words
A specific affinity reagent comprising a physiologically compatible polymer containing a plurality of negatively charged groups, a specific affinity compound having specific affinity for a target substance or cells, said specific affinity compound being bonded to said polymer, and at least one reporter group bonded to said polymer.
Claim 6
Dependent Claim
20 words
A specific affinity reagent as claimed in claim 3 wherein said polymer has a molecular weight less than 100 kd.
Claim 7
Dependent Claim
22 words
A specific affinity reagent as claimed in claim 3 or 4 wherein said polymer has a molecular weight less than 50 kd.
Claim 8
Dependent Claim
18 words
A specific affinity reagent as claimed in claim 3, 4 or 5 wherein said polymer is a polyaminoacid.
Claim 9
Dependent Claim
14 words
A specific affinity reagent as claimed in claim 6 wherein said polyaminoacid is polylysine.
Claim 10
Dependent Claim
24 words
A specific affinity reagent as claimed in any of claims 3 to 7 wherein said polymer contains a plurality of negatively charged carboxylate groups.
Claim 11
Dependent Claim
22 words
A specific affinity reagent as claimed in claim 8 wherein said specific affinity compound is bonded to a negatively charged carboxylate group.
Claim 12
Dependent Claim
26 words
A specific affinity reagent as claimed in claim 8 wherein said negatively charged carboxylate groups are attached to primary or secondary amino groups of said polymer.
Claim 13
Dependent Claim
25 words
A specific affinity reagent as claimed in any one of claims 3 to 10 wherein said specific affinity compound is an antibody or portion thereof.
Claim 14
Dependent Claim
29 words
A specific affinity reagent as claimed in any one of claims 3 to 11 wherein said reporter group is a paramagnetic substance, a radioactive substance or a cytotoxic substance.
References Cited (Backward Citations)
No citation records indexed.
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