EP0268167A2
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EP
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Analytical element for determination of hydrogen peroxide and analytical method using the same
Assignee: Konica Minolta Inc
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Filing: 1987-11-06
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Granted: —
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Expires: 2007-11-06
Abstract
Abstract Disclosed is an analytical element for determination of hydrogen peroxide, which comprises using an analytical element containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent. Disclosed is also an analytical method for determination of hydrogen peroxide by use of the above analytical element. As described in the foregoing, the analytical element of this invention can exhibit the remarkable effect that the determination sensitivity can be greatly improved.
Inventors
- 👤 Morio Kobayashi
- 👤 Masakazu Sugao
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 06:56
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521; G01N33/525; G01N33/526; C12Q2326/00; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10S435/81
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
117 words
An analytical method for determination of hydrogen peroxide, which comprises using an analytical element containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 2
Dependent Claim
117 words
An analytical method for determination of hydrogen peroxide, which comprises using an analytical element containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 3
Dependent Claim
23 words
The method of Claim 1, wherein said analytical element is used for the determination of uric acid, creatinine, glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase.
Claim 4
Dependent Claim
39 words
The method of Claim 1, wherein said compound represented by Formula (I) is a compound represented by Formula (II) shown below: wherein R₁, R₂ and X have the same meaning as R and X, respectively, defined in Formula (I).
Claim 5
Dependent Claim
84 words
The method of Claim 1, wherein said aromatic primary amine compound is a p-phenylenediamine compound represented by Formula (IX) shown below: wherein A and Bʹ each represent a hydrogen atom or an alkyl group, and A and Bʹ may form a heterocyclic ring together with a nitrogen atom; and Dʹ, E, G and J each represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, an alkoxy group, an acylamide group, an arylsulfonamide group, an alkylsulfonamide group or an alkyl group.
Claim 6
Dependent Claim
111 words
An analytical element for determination of hydrogen peroxide, containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 7
Dependent Claim
111 words
An analytical element for determination of hydrogen peroxide, containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 8
Dependent Claim
24 words
The analytical element of Claim 5, wherein said analytical element is used for the determination of uric acid, creatinine, glutamate-oxaloacetate transaminase and glutamate-piruvate transaminase.
Claim 9
Dependent Claim
40 words
The analytical element of Claim 5, wherein said compound represented by Formula (I) is a compound represented by Formula (II) shown below: wherein R₁, R₂ and X have the same meaning as R and X, respectively, defined in Formula (I).
Claim 10
Dependent Claim
85 words
The analytical element of Claim 5, wherein said aromatic primary amine compound is a p-phenylenediamine compound represented by Formula (IX) shown below. wherein A and Bʹ each represent a hydrogen atom or an alkyl group, and A and Bʹ may form a heterocyclic ring together with a nitrogen atom; and Dʹ, E, G and J each represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, an alkoxy group, an acylamide group, an arylsulfonamide group, an alkylsulfonamide group or an alkyl group.
Claim 11
Dependent Claim
143 words
An analytical element for determination of hydrogen peroxide, comprising a support having thereon a reagent layer and a porous spreading layer, and containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below, said compound represented by Formula (I) and said aromatic primary amine compound being contained in respectively different layers, wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 12
Dependent Claim
143 words
An analytical element for determination of hydrogen peroxide, comprising a support having thereon a reagent layer and a porous spreading layer, and containing a substance having the action of peroxidation, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below, said compound represented by Formula (I) and said aromatic primary amine compound being contained in respectively different layers, wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 13
Dependent Claim
24 words
The analytical element of Claim 9, wherein said analytical element is used for the determination of uric acid, creatinine, glutamate-oxaloacetate transaminase and glutamate-piruvate transaminase.
Claim 14
Dependent Claim
40 words
The analytical element of Claim 9, wherein said compound represented by Formula (I) is a compound represented by Formula (II) shown below: wherein R₁, R₂ and X have the same meaning as R and X, respectively, defined in Formula (I).
Claim 15
Dependent Claim
85 words
The analytical element of Claim 9, wherein said aromatic primary amine compound is a p-phenylenediamine compound represented by Formula (IX) shown below: wherein A and Bʹ each represent a hydrogen atom or an alkyl group, and A and Bʹ may form a heterocyclic ring together with a nitrogen atom; and Dʹ, E, G and J each represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, an alkoxy group, an acylamide group, an arylsulfonamide group, an alkylsulfonamide group or an alkyl group.
Claim 16
Dependent Claim
32 words
The analytical element of Claim 9, wherein said compound represented by Formula (I) is contained in said reagent layer, and said aromatic primary amine compound is contained in said porous spreading layer.
Claim 17
Dependent Claim
112 words
An analytical method for determination of hydrogen peroxide, which comprises using an analytical element containing ascorbate oxidase, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 18
Dependent Claim
112 words
An analytical method for determination of hydrogen peroxide, which comprises using an analytical element containing ascorbate oxidase, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 19
Dependent Claim
138 words
An analytical element for determination of hydrogen peroxide, comprising a support having thereon a reagent layer and a porous spreading layer, and containing ascorbate oxidase, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below, said compound represented by Formula (I) and said aromatic primary amine compound being contained in respectively different layers: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
Claim 20
Dependent Claim
138 words
An analytical element for determination of hydrogen peroxide, comprising a support having thereon a reagent layer and a porous spreading layer, and containing ascorbate oxidase, a compound represented by Formula (I) shown below, and an aromatic primary amine compound, or a salt thereof, capable of forming a dye through the coupling reaction with the compound represented by Formula (I) shown below, said compound represented by Formula (I) and said aromatic primary amine compound being contained in respectively different layers: wherein Z represents a group of nonmetallic atoms necessary for forming a nitrogen-containing heterocyclic ring, which ring formed by Z may have a substituent; X represents a hydrogen atom or a group capable of being split off through the reaction with an oxidized product of the aromatic primary amine compound; and R represents a hydrogen atom or a substituent.
References Cited (Backward Citations)
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