EP0267015A2
Expired / Lapsed
EP
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Stabilized compositions containing epidermal growth factor
Assignee: Ethicon Inc
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Filing: 1987-11-04
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Granted: —
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Expires: 2007-11-04
Abstract
Abstract Medicinal compositions containing a polypeptide growth factor having mitogenic activity are stabilized against loss of biological activity in the presence of moisture by including in said compositions a stabilizing amount of a water-soluble polysaccharide, preferably a cellulose derivative, such as methylcellulose or a hydroxy alkylcellulose, such as hydroxypropyl methylcellulose.
Inventors
- 👤 Amy L. Finkenaur
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 05:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A23; A23C; A23C9/00; A23C9/20; A23C9/206; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1808; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0048; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L17/00; A61L17/005; A61P; A61P17/00; A61P17/02; A61P27/00; A61P27/02; A61P5/00; A61P5/06; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/80; A61L2300/802
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
30 words
An aqueous medicinal composition containing a polypeptide growth factor having human mitogenic activity and an amount of water-soluble polysaccharide sufficient to stabilize said growth factor against loss of biological activity.
Claim 2
Dependent Claim
30 words
An aqueous medicinal composition containing a polypeptide growth factor having human mitogenic activity and an amount of water-soluble polysaccharide sufficient to stabilize said growth factor against loss of biological activity.
Claim 3
Dependent Claim
42 words
The composition of claim 1, wherein the growth factor is epidermal growth factor, transforming growth factor-alpha, transforming growth factor-beta, basic fibroblast growth factor, acidic fibroblast growth factor, anginogenin, nerve growth factor, insulin-like growth factor, platelet derived growth factor or a mixture thereof.
Claim 4
Dependent Claim
13 words
The composition of claim 2, wherein the growth factor is epidermal growth factor.
Claim 5
Dependent Claim
15 words
The composition of claim 3, wherein the epidermal growth factor is human epidermal growth factor.
Claim 6
Dependent Claim
17 words
The composition of any one of claims 1 to 4, wherein the polysaccharide is a cellulose derivative.
Claim 7
Dependent Claim
21 words
The composition of claim 5, wherein the cellulose derivative is hydroxypropyl cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose or a mixture thereof.
Claim 8
Independent Claim
70 words
A method for stabilizing an aqueous medicinal composition containing a polypeptide growth factor having mitogenic activity as defined in any one of claims 1 to 4 as an active ingredient, which method comprises incorporating in said composition an amount of a water-soluble polysacchardie as defined in any one of claims 1, 5 and 6 sufficient to stabilize said growth factor against loss of biological activity in the presence of water.
Claim 9
Dependent Claim
17 words
A pharmaceutically compatible cream or gel comprising the composition of any one of claims 1 to 6.
Claim 10
Dependent Claim
21 words
A suture or an absorbent gauze dressing coated or soaked with the composition of any one of claims 1 to 6.
Claim 11
Dependent Claim
37 words
The composition of any one of claims 1 to 6, the cream or gel of claim 8, or the suture or gauze dressing of claim 9 for use in increasing the rate of healing of a wound.
Claim 12
Dependent Claim
16 words
A mother's breast milk substitute comprising the composition of any one of claims 1 to 6.
Claim 13
Dependent Claim
25 words
A mother's breast milk substitute comprising recombinant human EGF and a nutritional amount of protein capable of providing the amino acids essential for human nutrition.
Claim 14
Dependent Claim
25 words
A mother's breast milk substitute comprising recombinant human EGF and a nutritional amount of protein capable of providing the amino acids essential for human nutrition.
Claim 15
Dependent Claim
38 words
A pharmaceutical composition for ophthalmic use, comprising: a) epidermal growth factor (EGF) at a concentration of about 1 to about 1000 micrograms/ml; and b) a water soluble, ophthalmically compatible polymer for maintaining viscosity within the range 1-5000 cps.
Claim 16
Dependent Claim
38 words
A pharmaceutical composition for ophthalmic use, comprising: a) epidermal growth factor (EGF) at a concentration of about 1 to about 1000 micrograms/ml; and b) a water soluble, ophthalmically compatible polymer for maintaining viscosity within the range 1-5000 cps.
Claim 17
Dependent Claim
20 words
The composition of claim 13, wherein the polymer is present at a concentration of about 0.05% to about 3.0% (w/v).
Claim 18
Dependent Claim
23 words
The composition of claim 13 or claim 14 for use in increasing the rate of healing of a wound in a subject's eye.
References Cited (Backward Citations)
No citation records indexed.
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