EP0267005A2
Expired / Lapsed
EP
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Compositions for preventing secondary cataracts
Assignee: Baylor College of Medicine
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Filing: 1987-11-03
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Granted: —
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Expires: 2007-11-03
Abstract
Abstract Novel methods and compositions are provided for preventing secondary cataracts. A cytotoxic agent is employed which is instilled into the anterior chamber of the eye to inhibit proliferation of remnant epithelial cells after extracapsular cataract extraction. Desirably a non-cytotoxic agent cross-reactive with the cytotoxic agent is instilled prior to instillation of the cytotoxic agent. The agents can be provided as kits.
Inventors
- 👤 Dominic Man-Kit Lam
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 22:11
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6819; A61K47/6825; A61K47/6827; A61K47/6835; A61K47/6845; A61P; A61P27/00; A61P27/02; A61P27/12; A61K38/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
15 words
A composition comprising a macromolecular protein specific for epithelial cells conjugated to a cytotoxic agent.
Claim 2
Dependent Claim
15 words
A composition comprising a macromolecular protein specific for epithelial cells conjugated to a cytotoxic agent.
Claim 3
Dependent Claim
17 words
A composition according to Claim 1, wherein said macromolecular protein is a monoclonal antibody or fragment thereof.
Claim 4
Dependent Claim
21 words
A composition according to Claim 1 or Claim 2, wherein said cytotoxic agent is the A chain of a cytotoxic agent.
Claim 5
Dependent Claim
25 words
A composition according to claim 3, wherein said A chain is the ricin A chain, the abrin A chain, or the diphtheria toxin A chain.
Claim 6
Dependent Claim
27 words
A kit comprising a first container containing a cytotoxic agent specific for epithelial cells and a second container containing a non-cytotoxic agent cross-reactive with said cytotoxic agent.
Claim 7
Dependent Claim
27 words
A kit comprising a first container containing a cytotoxic agent specific for epithelial cells and a second container containing a non-cytotoxic agent cross-reactive with said cytotoxic agent.
Claim 8
Dependent Claim
19 words
Macromolecular proteins specific for epithelial cells conjugated to a cytotoxic agent, for use in the treatment of secondary cataracts.
Claim 9
Dependent Claim
19 words
Macromolecular proteins specific for epithelial cells conjugated to a cytotoxic agent, for use in the treatment of secondary cataracts.
Claim 10
Dependent Claim
18 words
The conjugated proteins claimed in Claim 6, in conjunction with a non-cytotoxic agent crossreactive with the cytotoxic agent.
Claim 11
Dependent Claim
34 words
A method of making a composition according to Claim 1 or proteins as claimed in Claims 6 and 7 comprising selecting a protein specific for epithelial cells and conjugating it to a cytotoxic agent.
Claim 12
Dependent Claim
16 words
A method according to Claim 8 wherein the protein is a monoclonal antibody or fragment thereof.
Claim 13
Dependent Claim
28 words
A method according to Claim 8 or Claim 9 wherein the cytotoxic agent is the ricin A chain, the abrin A chain, or the diphtheria toxin A chain.
References Cited (Backward Citations)
No citation records indexed.
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